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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Component Analysis and Free Radicals Scavenging Activity of Physalis alkekengi L. Polysaccharide显示文摘A crude polysaccharide was extracted from Physalis alkekengi L. fruit. HPLC was used for the component analysis of the polysaccharide. The results indicate that Physalis alkekengi L. polysaccharide(PAP) was composed of rhamnose, xylose, arabinose, galactose, and glucose. Free radicals scavenging activity of PAP was studied through 3 free radicals scavenging tests. PAP exhibited high scavenging effects on OH and DPPH radicals, and both the scavenging rates were about 80%. The scavenging rate of O2 radical was about 22%. | CHENG Ying-kun LI Lei MENG Zhao-kun HOU A-li WU Yu-jie TENG Li-rong | 2008 | Chemical Research in Chinese Universities2008，24，2： | 18 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Baihui(DU20)-penetrating-Qubin(GB7) acupuncture inhibits apoptosis in the perihemorrhagic penumbra显示文摘Baihui(DU20)-penetrating-Qubin(GB7) acupuncture can inhibit inflammatory reactions and activate signaling pathways related to proliferation after intracerebral hemorrhage.However,there is no research showing the relationship between this treatment and cell apoptosis.Rat models of intracerebral hemorrhage were established by injecting 60 μL of autologous blood into the right side of the caudate-putamen.Six hours later,the needle traveled subcutaneously from the Baihui acupoint to Qubin acupoint.The needle was alternately rotated(180 ± 10 turns/min) manually along clockwise and counter-clockwise directions.Stimulation lasted for 7 days,and was performed three times each for 6 minutes with 6-minute intervals between stimulations.Rats intraperitoneally receiving Sonic hedgehog pathway activator,purmorphamine(1 mg/kg per day),served as positive controls.Motor and sensory function were assessed using the Ludmila Belayev test.Extent of pathological changes were measured in the perihemorrhagic penumbra using hematoxylin-eosin staining.Apoptosis was examined by terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling assay.Expression of smoothened(Smo) and glioma-associated homolog 1(Gli1) was determined by western blot assay.Our results showed that Baihui-penetrating-Qubin acupuncture promoted recovery of motor and sensory function,reduced the apoptotic cell percentage in the perihemorrhagic penumbra,and up-regulated Smo and Gli1 expression.We conclude that Baihui-penetrating-Qubin acupuncture can mitigate hemorrhage and promote functional recovery of the brain in a rat model of intracerebral hemorrhage,possibly by activating the Sonic hedgehog pathway. | Beng Zhang Xiao-Hong Dai Xue-Ping Yu Wei Zou Wei Teng Xiao-Wei Sun Wei-Wei Yu Hao Liu Hui Wang Meng-Juan Sun Meng Li | 2018 | Neural Regeneration Research2018，13，9： | 9 |
| 5 | Preparation of Tolterodine Metabolite Loaded Biodegradable PLGA Microspheres显示文摘Biodegradable polymer poly(lactic-co-glycolic acid)(PLGA) was used to encapsulate the pharmacological activity metabolite of tolterodine by means of O/W emulsion solvent evaporation method via homogenization in the emulsification process. The influences of preparation parameters were investigated. The results indicate that increasing PLGA concentration from 15% to 40% made the encapsulation efficiency of 5-hydroxymethyl derivative of tolterodine(5-HMT) increased from 55.39% to 76.32%, and the particle size increased from 34.33 μm to 70.78 μm. In addition, when homogenization speed increased from 850 r/min to 2300 r/min, both particle size and encapsulation efficiency of microspheres decreased. An increase in the volume of aqueous phase led to higher encapsulation efficiency and bigger particle size. Increasing temperature made encapsulation efficiency and particle size change significantly. While reaction temperature increased from 20 °C to 50 °C, the encapsulation efficiency decreased from 70.44% to 24.07%, and particle size increased from 38.66 μm to 69.38 μm. High reaction temperature(over 40 °C) may lead to porous surface of microspheres. Porous surface, encapsulation efficiency and particle size influenced on the in vitro release of 5-HMT together. | TENG Le-sheng JIANG Chao-jun LIN Xiang-you DONG Yuan-chen LI Chun-mei MENG Qing-fan LI You-xin | 2010 | Chemical Research in Chinese Universities2010，26，1： | 8 |
| 6 | Effects of water regime, crop residues, and application rates on control of Fusarium oxysporum f.sp.cubense显示文摘Biological soil disinfestation is an effective method to control soil-borne disease by flooding and incorporating with organic amendments, but field conditions and resources sometimes limited its practical application. A laboratory experiment was conducted to develop practice guidelines on controlling Fusarium wilt, a widespread banana disease caused by Fusarium oxysporum f. sp. cubense(FOC). FOC infested soil incorporated with rice or maize straw at rates of 1.5 tons/ha and 3.0 tons/ha was incubated under flooded or water-saturated(100% water holding capacity) conditions at 30℃ for 30 days. Results showed that FOC populations in the soils incorporated with either rice or maize straw rapidly reduced more than 90% in the first 15 days and then fluctuated till the end of incubation, while flooding alone without organic amendment reduced FOC populations slightly. The rapid and dramatic decrease of redox potential(down to- 350 m V) in straw-amended treatments implied that both anaerobic condition and strongly reductive soil condition would contribute to pathogen inactivation. Water-saturation combined with straw amendments had the comparable effects on reduction of FOC, indicating that flooding was not indispensable for inactivating FOC. There was no significant difference in the reduction of FOC observed in the straw amendments at between 1.5 and 3 tons/ha. Therefore,incorporating soil with straw(rice or maize straw) at a rate of 3.0 tons/ha under 100%water holding capacity or 1.5 tons/ha under flooding, would effectively alleviate banana Fusarium wilt caused by FOC after 15-day treating under 30℃. | Teng Wen Xinqi Huang Jinbo Zhang Tongbin Zhu Lei Meng Zucong Cai | 2015 | Journal of Environmental Sciences2015，27，5： | 8 |
| 7 | Genetic progress in stem lodging resistance of the dominant wheat cultivars adapted to Yellow-Huai River Valleys Winter Wheat Zone in China since 1964显示文摘Analysis of genetic progress for lodging-related traits provides important information for further improvement of lodging resistance.Forty winter wheat cultivars widely grown in the Yellow-Huai River Valleys Winter Wheat Zone(YHWZ)of China during the period of 1964–2015 were evaluated for several lodging-related traits in three cropping seasons.Plant height,height at center of gravity,length of the basal second internode,and lodging index decreased significantly in this period,and the average annual genetic gains for these traits were–0.50 cm or–0.62%,–0.27 cm or–0.60%,–0.06 cm or–0.63%,and–0.01 or–0.94%,respectively.Different from other traits,stem strength showed a significant increasing trend with the breeding period,and the annual genetic gains were 0.03 N or 0.05%.Correlation analysis showed that lodging index was positively correlated with plant height,height at center of gravity,and length of the basal second internode,but negatively correlated with stem strength.Meanwhile,significantly positive correlations were observed between plant height,height at center of gravity,and length of the basal first and second internodes.By comparison with the wild types,dwarfing genes had significant effects on all lodging-related traits studied except for length of the basal first internode and stem strength.Principle component analysis demonstrated that plant height and stem strength were the most important factors influencing lodging resistance.Clustering analysis based on the first two principle components further indicated the targets of wheat lodging-resistant breeding have changed from reducing plant height to strengthening stem strength over the breeding periods.This study indicates that the increase of stem strength is vital to improve lodging resistance in this region under the high-yielding condition when plant height is in an optimal range. | ZHANG Hong-jun LI Teng LIU Hong-wei MAI Chun-yan YU Guang-jun LI Hui-li YU Li-qiang MENG Ling-zhi JIAN Da-wei YANG Li LI Hong-jie ZHOU Yang | 2020 | Journal of Integrative Agriculture2020，19，2： | 7 |
| 8 | An Improved Support Vector Clustering Approach to Dynamic Aggregation of Large Wind Farms显示文摘In this paper,we propose an improved support vector clustering(SVC)algorithm to cluster wind turbines(WTs)in a wind farm(WF).A boundary points(BPs)detecting method based on the grid theory and the connected subdomain(CS)are proposed.Thus the efficiency of SVC is enhanced while maintaining the accuracy of the algorithm.As for the multi-wind condition equivalent of WF,a method to determine the number and capacity of each of the aggregated wind turbines(AWTs)based on historical wind data is proposed.Only wind speed(WS)and wind direction(WD)of the WF are needed to calculate the WSs of each AWT.Results demonstrate that the algorithm proposed in this paper can cluster WTs quickly and accurately.And the dynamic aggregated models of the WFs are suitable for both the single-wind condition and multi-wind condition simulations,with high accuracy being obtained. | Weijun Teng Xifan Wang Yongqing Meng Wenhui Shi | 2019 | CSEE Journal of Power and Energy Systems2019，5，2： | 7 |
| 9 | Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high-and low-incidence areas显示文摘Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma(ESCC).Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidence areas for both GCA and ESCC in China. Taq Man allele discrimination assay was used to genotype the rs671 polymorphism. χ~2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population(P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidence areas for both GCA and ESCC was lower than that in low-incidence areas(P<0.001).Conclusions: Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China. | Lian-Qun Zhang Xin Song Xue-Ke Zhao Jia Huang Peng Zhang Lu-Wen Wang Hui Meng Jian-Wei Ku Guo-Qiang Kong Tao Jiang Xin-Min Li Xiao-Long Lv Teng Ma Guo Yuan Min-Jie Wu Shou-Jia Hu Shuang Lv Tang-Juan Zhang Ling-Fen Ji Zong-Min Fan Neng-Chao Wang Yao-Wen Zhang Fu-You Zhou Li-Dong Wang | 2017 | Cancer Biology & Medicine2017，14，1： | 7 |
| 10 | Optimization of Fermentation Medium for Epothilones Production with Sequential Statistical Approach显示文摘A sequential statistical approach was applied to optimizing the fermentation medium of epothilones(Epos) production by means of a mutant which was obtained by treating polyangium cellulosum ATCC 15384 with nitrite and ultraviolet. The effects of different carbon sources and nitrogen sources on the fermentation medium were tested, and the suitable ones were selected. Then a uniform design was employed to design the experiments. A linear model was developed for identifying the significant components in fermentation medium, while a third degree polynomial model was used for studying the relationship between the concentration of the components in fermentation medium and the yield of Epos(YEPs). A pattern search method was used for searching the optimum fermentation medium in the test space, which was as follows(g/L): potassium nitrate 8.00, soybean peptone 17.60, potassium hydrogen phosphate 1.00, beef extraction 6.46, yeast extraction 1.00, calcium chloride 0.25, sodium chloride 1.00 and ferric chloride 0.02. The optimum fermentation medium was expected to result in a yield of Epos(YEPs) of 2.48 mg/L. The validation experiments with the optimum medium were performed in triplicate and the average yield of Epos was 2.45 mg/L which was 7.78 times higher than that of Epos prepared without optimization. | MENG Fan-xin LI You-xin GUO Wei-liang LU Jia-hui DU Lin-na TENG Li-rong | 2010 | Chemical Research in Chinese Universities2010，26，1： | 6 |
| 11 | The optic nerve head perfusion and its correlation with the macular blood perfusion in unilateral idiopathic macular hole: an optical coherence tomography angiography study显示文摘AIM: To compare the optic nerve head(ONH) perfusion in both eyes of unilateral idiopathic macular hole(IMH) with normal control group by using optical coherence tomography angiography(OCTA) and investigate its correlationship with the macular blood perfusion.METHODS: We performed a prospective and crosssectional study that included 19 patients with full-thickness unilateral IMH and 24 age-and sex-matched controls. All participants received OCTA test. The ONH perfusion was evaluated by the regions of peripapillary and whole en face(the sum of peripapillary and optic disc). The potential correlationship between ONH and parafovea were implied. All the data were performed using the nonparametric test.RESULTS: The mean values of ONH presented that normal control >IMH >unaffected eyes. A statistical variation was found between three groups in the region of temporal(P=0.007). Vessel density notablely decreased on the layers of superficial, deep and choroid of parafovea region in IMH group. The correlative coefficients showed that respectively whole en face and deep retina: r=0.528, peripapillary and deep retina: r=0.525, whole en face and choriocapillaries: r=0.569, peripapillary and choriocapillaries: r=0.504.CONCLUSION: Our study demonstrate a reduced ONH vessel density in both eyes of IMH patients and the vessel density of ONH in IMH eyes are positively correlated with both the retina capillary and choriocapillary in parafoveal. The reduction of vessel densities may indicate the hypoperfusion in IMH eyes. | Xin-Xin Liu Yu-Fei Teng Meng Gao Xi-Da Liang Yan-Ping Yu Wu Liu | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 6 |
| 12 | Nitrogen application and intercropping change microbial community diversity and physicochemical characteristics in mulberry and alfalfa rhizosphere soil显示文摘Intercropping of mulberry(Morus alba L.)and alfalfa(Medicago sativa L.)is a new forestry-grass compound model in China,which can provide high forage yields with high protein.Nitrogen application is one of the important factors determining the production and quality of this system.To elucidate the advantages of intercropping and nitrogen application,we analyzed the changes of physicochemical properties,enzyme activities,and microbial communities in the rhizosphere soil.We used principal components analysis(PCA)and redundancy discriminators analysis to clarify the relationships among treatments and between treatments and environmental factors,respectively.The results showed that nitrogen application significantly increased pH value,available nitrogen content,soil water content(SWC),and urea(URE)activity in rhizosphere soil of monoculture mulberry.In contrast,intercropping and intercropping+N significantly decreased pH and SWC in mulberry treatments.Nitrogen,intercropping and intercropping+N sharply reduced soil organic matter content and SWC in alfalfa treatments.Nitrogen,intercropping,and intercropping+N increased the values of McIntosh diversity(U),Simpson diversity(D),and Shannon-Weaver diversity(H’)in mulberry treatments.However,PC A scatter plots showed clustering of monoculture mulberry with nitrogen(MNE)and intercropping mulberry without nitrogen(M0).Intercropping reduced both H’and D but nitrogen application showed no effect on diversity of microbial communities in alfalfa.There were obvious differences in using the six types of carbon sources between mulberry and alfalfa treatments.Nitrogen and intercropping increased the numbers of sole carbon substrate in mulberry treatments where the relative use rate exceeded 4%.While the numbers declined in alfalfa with nitrogen and intercropping.RDA indicated that URE was positive when intercropping mulberry was treated with nitrogen,but was negative in monoculture alfalfa treated with nitrogen.Soil pH and SWC were positive with mulberry treatments but were negative with alfalfa treatments.Intercropping with alfalfa benefited mulberry in the absence of nitrogen application.Intercropping with alfalfa and nitrogen application could improve the microbial community function and diversity in rhizosphere soil of mulberry.The microbial community in rhizosphere soil of mulberry and alfalfa is strategically complementary in terms of using carbon sources. | Xiuli Zhang Zhiyuan Teng Huihui Zhang Dunjiang Cai Jingyun Zhang Fanjuan Meng Guangyu Sun | 2021 | Journal of Forestry Research2021，32，5： | 5 |
| 13 | Isolation,Purification and Bioactivities of Polysaccharides from Irpex lacteus显示文摘Irpex lacteus has been widely used for treating chronic glomerulonephritis as a traditional Chinese medicine.Seven water-soluble polysaccharide fractions(ILN I,ILN II,ILN III,ILA I,ILA II,ILB I and ILB II) were isolated and purified from Irpex lacteus by hot-water extraction,deproteinization,decolorization,dicthy laminoethyl(DEAE)-cellulose ion exchange and sephadex G100 chromatographies,respectively.The average molecular weights and monosaccharide composition of these polysaccharide fractions greatly differed from each other.The antitumor and antinephritis activities of the seven polysaccharide fractions were evaluated.It was found that ILN III displayed significant inhibition effects on both humar hepatocellular liver carcinoma(HepG2) and hentietta lacks(HeLa) tumor cells with IC 50 values of 60.95 and 99.95 μg/mL,respectively.ILA I exhibited significant inhibition effects on murine mesangial cells(HBZT-1) with an IC 50 value of 185.06 μg/mL.The inhibition effects of other polysaccharide fractions on these three cells were significantly different.These results suggest that the polysaccharide fractions isolated from Irpex lacteus have potential antitumor and antinephritis activities. | ZHANG Na LIU Yan LUJia-hui WANG Juan YANG Shuang ZHANG Nan MENG Qing-fan TENG Li-rong | 2012 | Chemical Research in Chinese Universities2012，28，2： | 5 |
| 14 | Diabetes recurrence after metabolic surgeries correlates with re-impaired insulin sensitivity rather than beta-cell function显示文摘AIM To investigate factors causing diabetes recurrence after sleeve gastrectomy(SG)and duodenal-jejunal bypass(DJB).METHODS SG and DJB were performed on rats with diabetes induced by high-fat diet(HFD)and streptozotocin(STZ).HFD was used to induce diabetes recurrence at 4 wk postoperatively.Body weight,oral glucose tolerance test,homeostatic model assessment of insulin resistance(HOMA-IR),insulin signaling[IR,insulin receptor substrate(IRS 1,IRS2,phosphatidylinositol3-kinase and AKT in liver and skeletal muscle],oral glucose stimulated insulin secretion,beta-cell morphology(mass,apoptosis and insulin secretion),glucagon-like peptide(GLP)-1,PYY and ghrelin were compared among SG rats with common low-fat diet(SG-LFD),SG with HFD(SG-HFD),DJB rats with LFD(DJB-LFD),DJB with HFD(DJB-HFD)and shamoperation with LFD(Sham)at targeted postoperative times.RESULTS SG and DJB resulted in significant improvement in glucose tolerance,lower HOMA-IR,up-regulated hepatic and muscular insulin signaling,higher levels of oral glucose-stimulated insulin secretion,bigger betacell mass,higher immunofluorescence intensity of insulin,fewer transferase-mediated d UTP-biotin 3’nick end-labeling(TUNEL)-positive beta cells and higher postprandial GLP-1 and PYY levels than in the Sham group.The improvement in glucose tolerance was reversed at 12 wk postoperatively.Compared with the SG-LFD and DJB-LFD groups,the SG-HFD and DJB-HFD groups showed higher HOMA-IR,down-regulated hepatic and muscular insulin signaling,and more TUNEL-positive beta cells.No significant difference was detected between HFD and LFD groups for body weight,glucose-stimulated insulin secretion,betacell mass,immunofluorescence intensity of insulin,and postprandial GLP-1 and PYY levels.Fasting serum ghrelin decreased in SG groups,and there was no difference between HFD-SG and LFD-SG groups.CONCLUSION HFD reverses the improvement in glucose homeostasis after SG and DJB.Diabetes recurrence may correlate with re-impaired insulin sensitivity,but not with alterations of beta-cell function and body weight. | Teng Liu Ming-Wei Zhong Yi Liu Dong Sun Meng Wei Xin Huang Yu-Gang Cheng Qun-Zheng Wu Dong Wu Xiao-Qian Zhang Ke-Xin Wang San-Yuan Hu Shao-Zhuang Liu | 2017 | World Journal of Gastroenterology2017，23，19： | 5 |
| 15 | Isolation and Purification of Polysaccharides from Cordyceps minlitaris and Its Inhibition on the Proliferation of Rat Glomerular Mesangial Cells显示文摘The crude polysaccharide was obtained by means of the decolorization of porphyrized Cordyceps minlitaris stroma with organic solvent, extraction with hot water, precipitation in 80% ethanol, and protein removal with the Sevag method. After purification with Sephadex G-75, two of its components, CMP-1 and CMP-2, were obtained. Through the assay of gel chromatography and polarimetry, CMP-1 was identified as pure polysaccharide. The results demonstrated that CMP-1 had favorable oxidation resistance activity, which could scavenge not only oxygen-free radicals in the self-oxidation system of pyrogallic acid, but also the hydroxide-free radicals in the Fenton system. The study focused on the effects of low, medium, and high dosages of CMP-1 in rat blood serum on the proliferation of glomerular mesangial cells in vitro. Through MTT Colorimetric analysis, the activities were compared among the blank control group and the Niaoduqing positive control group CMP-1 and CMP-2. The results shows that CMP-1 was able to inhibit the proliferation of rat glomerular mesangial cells effectively. Therefore, CMP-1, one component of polysaccharides of Cordyceps minlitaris, was certainly a potential remedy for hyperplastic glomerular nephritis, whose antioxidant activity could slow down the process of chronic renal failure(CRF) to some extent. | HOU A-li MENG Qing-fan AN Jin-shuang ZHU Kai FENG Yun TENG Li-rong | 2008 | Chemical Research in Chinese Universities2008，24，5： | 4 |
| 16 | MIMO-SAR waveforms separation based on virtual polarization filter显示文摘The unwanted coupling exists inevitably among multiple orthogonal waveforms in a same frequency area for multiple-input and multiple-output synthetic aperture radar(MIMO-SAR). In this paper, a new polarized MIMO-SAR model is established with two transmitting antennas and multiple receiving antennas at first. Then, a virtual polarization filter(VPF) is proposed to separate superposed returns caused by multiple transmitted waveforms based on detection on the polarized parameters via particle swarm optimizer(PSO).Compared with the conventional matched filter to separate the orthogonal waveforms, it is shown that the coupling noises can be significantly suppressed by the proposed VPF-based method and the orthogonality is not necessary among different transmitting waveforms. Finally, experimental data experiments are also provided to demonstrate the effectiveness of the proposed method. | MENG CangZhen XU Jia XIA Xiang-Gen LIU Feng LONG Teng MAO ErKe YANG Jian PENG YingNing | 2015 | Science China(Information Sciences)2015，58，4： | 4 |
| 17 | Sphericities of non-spherical objects显示文摘Sphericity, as one of the most important shape parameter for non-spherical objects, is extensively applied in evaluating the porosity or packing density of particles. In this paper, the sphericities of common non- spherical objects are deduced and investigated. Maximum sphericities and optimum shapes of these objects are presented as well. A decreasing order of sphericity from sphere (1.0) to regular tetrahedron (0.671) for objects with constant sphericity is given. Similar trends are found in most sphericity-aspect ratio relationships, which exhibit single peak and the sphericity increases with the growth of aspect ratio before the peak point and decreases afterward. The peak loci of aspect ratio are all around 1.0 which makes the shape approaching to a sphere. The information in the paper could be useful as literature for general application. | Teng Li Shuixiang Li Jian Zhao Peng Lu Lingyi Meng | 2012 | Particuology2012，10，1： | 4 |
| 18 | Effects of resistin-like molecule β over-expression on gastric cancer cells in vitro显示文摘AIM: To investigate the effects of resistin-like molecule β (RELMβ) over-expression on the invasion, metastasis and angiogenesis of gastric cancer cells. METHODS: Human RELMβ encoding expression vec tor was constructed and transfected into the RELMβ lowly-expressed gastric cancer cell lines SGC7901 and MKN-45. Gene expression was measured by Western blotting, reverse transcription polymerase chain reaction (PCR) and real-time quantitative PCR. Cell proliferation was measured by 2-(4,5-dimethyltriazol-2-yl)-2,5-diphenyl tetrazolium bromide colorimetry, colony formation and 5-ethynyl-20-deoxyuridine incorporation assays. The in vitro migration, invasion and metastasis of cancer cells were measured by cell adhesion assay, scratch assay and matrigel invasion assay. The angiogenic capabilities of cancer cells were measured by tube formation of endothelial cells. RESULTS: Transfection of RELMβ vector into SGC-7901 and MKN-45 cells resulted in over-expression of RELMβ, which did not infl uence the cellular proliferation. However, over-expression of RELMβ suppressed the in vitro adhesion, invasion and metastasis of cancer cells, accompanied by decreased expression of matrix metalloproteinase-2 (MMP-2) and MMP-9. Moreover, transfection of RELMβ attenuated the expression of vascular endothelial growth factor and in vitro angiogenic capabilities of cancer cells. CONCLUSION: Over-expression of RELMβ abolishes the invasion, metastasis and angiogenesis of gastric cancer cells in vitro, suggesting its potentials as a novel therapeutic target for gastric cancer. | Li-Duan Zheng Ling Tong Chun-Lei Yang Teng Qi Meng Qi Qiang-Song Tong | 2012 | World Journal of Gastroenterology2012，18，8： | 4 |
| 19 | First-order Derivative Spectrophotometry for the Determination of Vitamin C in Medicament显示文摘A novel method for the determination of vitamin C(Vc) is proposed in this article. After the reaction with Folin-Ciocalteau reagent at ambient temperature, Vc solution was scanned at 750―1100 nm, and its first-order derivative spectrum were obtained from the original spectrum. The values of derivative selected at 995 nm were used for determination. It was proved that Vc could quickly react with Folin-Ciocalteau reagent within 5 min and the product was quite stable for a long time. The conditions required for this method is not very complicated, its precision and accuracy are similar to those of the iodometric titration described in Chinese Pharmacopoeia, and the limit of detection is 0.312 μg/mL. The determination of the results of vitamin C tablet, pill, and injection demonstrates that this method has wide pharmaceutical applications. | MENG Qing-fan TENG Le-sheng JIANG Chao-jun An Jin-shuang LI Lei LU Jia-hui TENG Li-rong | 2008 | Chemical Research in Chinese Universities2008，24，1： | 3 |
| 20 | Synthesis of a Dichlorosilaimine Coordinated by an N-Heterocyclic Carbene from ArN(SiMe3)SiHCl2显示文摘稳定 NHC 的 dichlorosilaimine ArN=Si (IiPr ) Cl 2(2 )(Ar=2,6-iPr 2 C 6 H 3, IiPr=1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene ) 并且 disilane LSiHCl-SiCl 2 L (L=ArNSiMe 3)(3 ) 能从 aminodichlorosilane ArN 的反应被综合(有在不同条件下面的 IiPr 的 SiMe 3)SiHCl2(1 ) 。这经由 dehydrosilylation 面对 NHC 从代替的 chlorosilane 代表第一条线路到稳定施主的 dichlorosilaimine 的产生。 | Haiyan Cui Peng Teng Enbin Zhang Jiahao Lu Fan Zhang Meng Wu | 2017 | Chinese Journal of Chemistry2017，35，4： | 3 |
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