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| 1 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 2 | Comparative study on the corrosion behavior of X52, 3Cr, and 13Cr steel in an O2–H2O–CO2 system: products, reaction kinetics, and pitting sensitivity显示文摘The corrosion behaviors of X52, 3Cr low-alloy steel, and 13Cr stainless steel were investigated in an O_2–H2O–CO_2 environment at various temperatures and O_2–CO_2 partial-pressure ratios. The results showed that the corrosion rates of X52, 3Cr, and 13Cr steels increased with increasing temperature. The corrosion rates slowly increased at temperatures less than 100°C and increased sharply when the temperature exceeded 100°C. In the absence of O_2, X52, 3Cr, and 13Cr exhibited uniform corrosion morphology and Fe CO3 was the main corrosion product. When O_2 was introduced into the system, various forms of Fe_2O_3 appeared on the surface of the samples. The Cr content strongly influenced the corrosion resistance. The 3Cr steel with a low Cr content was more sensitive to pitting than the X52 or 13Cr steel. Thus, pitting occurred on the surface of 3Cr when 1.25 MPa of O_2 was added; this phenomenon is related to the non-uniform distribution of Crin 3Cr. | Bing-wei Luo Jie Zhou Peng-peng Bai Shu-qi Zheng Teng An Xiang-li Wen | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，6： | 10 |
| 3 | Cryogenic minimum quantity lubrication machining: from mechanism to application显示文摘Cutting fluid plays a cooling-lubrication role in the cutting of metal materials.However,the substantial usage of cutting fluid in traditional flood machining seriously pollutes the environment and threatens the health of workers.Environmental machining technologies,such as dry cutting,minimum quantity lubrication(MQL),and cryogenic cooling technology,have been used as substitute for flood machining.However,the insufficient cooling capacity of MQL with normal-temperature compressed gas and the lack of lubricating performance of cryogenic cooling technology limit their industrial application.The technical bottleneck of mechanical-thermal damage of difficult-to-cut materials in aerospace and other fields can be solved by combining cryogenic medium and MQL.The latest progress of cryogenic minimum quantity lubrication(CMQL)technology is reviewed in this paper,and the key scientific issues in the research achievements of CMQL are clarified.First,the application forms and process characteristics of CMQL devices in turning,milling,and grinding are systematically summarized from traditional settings to innovative design.Second,the cooling-lubrication mechanism of CMQL and its influence mechanism on material hardness,cutting force,tool wear,and workpiece surface quality in cutting are extensively revealed.The effects of CMQL are systematically analyzed based on its mechanism and application form.Results show that the application effect of CMQL is better than that of cryogenic technology or MQL alone.Finally,the prospect,which provides basis and support for engineering application and development of CMQL technology,is introduced considering the limitations of CMQL. | Mingzheng LIU Changhe LI Yanbin ZHANG Qinglong AN Min YANG Teng GAO Cong MAO Bo LIU Huajun CAO Xuefeng XU Zafar SAID Sujan DEBNATH Muhammad JAMIL Hafz Muhammad ALI Shubham SHARMA | 2021 | Frontiers of Mechanical Engineering2021，16，4： | 8 |
| 4 | Effect of Spleen Lymphocytes on the Splenomegaly in Hepatocellular Carcinoma-bearing Mice显示文摘Objective To study the effect of spleen lymphocytes on the splenomegaly by hepatocellular carcinoma-bearing mouse model. Methods Cell counts,cell cycle distribution,the percentage of lymphocytes subsets and the levels of IL-2 were measured,and two-dimensional gel electrophoresis(2-DE) was used to investigate the relationship between spleen lymphocytes and splenomegaly in hepatocellular carcinoma-bearing mice. Results Compared with the normal group,the thymus was obviously atrophied and the spleen was significantly enlarged in the tumor-bearing group. Correlation study showed that the number of whole spleen cells was positively correlated with the splenic index. The cell diameter and cell-cycle phase distribution of splenocytes in the tumor-bearing group showed no significant difference compared to the normal group. The percentage of CD3+ T lymphocytes and CD8+ T lymphocytes in spleen and peripheral blood of tumor-bearing mice were substantially higher than that in the normal mice. Meanwhile,the IL-2 level was also higher in the tumor-bearing group than in the normal group. Furthermore,two dysregulated protein,β-actin and S100-A9 were identi?ed in spleen lymphocytes from H22-bearing mice,which were closely related to cellular motility. Conclusion It is suggested that dysregulated β-actin and S100-A9 can result in recirculating T lymphocytes trapped in the spleen,which may explain the underlying cause of splenomegaly in H22-bearing mice. | FANG Jing Jing ZHU Zhen Yuan DONG Hui ZHENG Guo Qiang TENG An Guo LIU An Jun | 2014 | Biomedical and Environmental Sciences2014，27，1： | 6 |
| 5 | A genetic diversity assessment of starch quality traits in rice landraces from the Taihu basin,China显示文摘There are nearly 1 000 rice landrace varieties in the Taihu basin, China. To assess the genetic diversity of the rice, 24 intragenic molecular markers(representing 17 starch synthesis-related genes) were investigated in 115 Taihu basin rice landraces and 87 improved cultivars simultaneously. The results show that the average genetic diversity and polymorphism information content values of the landraces were higher than those of improved cultivars. In total, 41 and 39 allele combinations(of the 17 genes) were derived from the landraces and improved cultivars, respectively; only two identical allele combinations were found bet ween the two rice variety sources. Cluster analysis, based on the molecular markers, revealed that the rice varieties could be subdivided into five groups and, within these, the japonica improved rice and japonica landrace rice varieties were in two separate groups. According to the quality reference criteria to classify the rice into grades, some of the landraces were found to perform we ll, in terms of starch quality. For example, according to NY /T595-2002 criteria from the Ministry of Agriculture of China, 25 and 33 landraces reached grade 1, in terms of their apparent amylose content and gel consistency. Th e varieties that had outstanding quality could be used as breeding materials for rice quality breeding programs in the future. Our study is useful for future applications, such as genetic diversity studies, the protection of rice variety and improvment of rice quality in breeding programs. | AO Yan XU Yong CUI Xiao-fen WANG An TENG Fei SHEN Li-qun LIU Qiao-quan | 2016 | Journal of Integrative Agriculture2016，15，3： | 5 |
| 6 | Isolation and Purification of Polysaccharides from Cordyceps minlitaris and Its Inhibition on the Proliferation of Rat Glomerular Mesangial Cells显示文摘The crude polysaccharide was obtained by means of the decolorization of porphyrized Cordyceps minlitaris stroma with organic solvent, extraction with hot water, precipitation in 80% ethanol, and protein removal with the Sevag method. After purification with Sephadex G-75, two of its components, CMP-1 and CMP-2, were obtained. Through the assay of gel chromatography and polarimetry, CMP-1 was identified as pure polysaccharide. The results demonstrated that CMP-1 had favorable oxidation resistance activity, which could scavenge not only oxygen-free radicals in the self-oxidation system of pyrogallic acid, but also the hydroxide-free radicals in the Fenton system. The study focused on the effects of low, medium, and high dosages of CMP-1 in rat blood serum on the proliferation of glomerular mesangial cells in vitro. Through MTT Colorimetric analysis, the activities were compared among the blank control group and the Niaoduqing positive control group CMP-1 and CMP-2. The results shows that CMP-1 was able to inhibit the proliferation of rat glomerular mesangial cells effectively. Therefore, CMP-1, one component of polysaccharides of Cordyceps minlitaris, was certainly a potential remedy for hyperplastic glomerular nephritis, whose antioxidant activity could slow down the process of chronic renal failure(CRF) to some extent. | HOU A-li MENG Qing-fan AN Jin-shuang ZHU Kai FENG Yun TENG Li-rong | 2008 | Chemical Research in Chinese Universities2008，24，5： | 4 |
| 7 | First-order Derivative Spectrophotometry for the Determination of Vitamin C in Medicament显示文摘A novel method for the determination of vitamin C(Vc) is proposed in this article. After the reaction with Folin-Ciocalteau reagent at ambient temperature, Vc solution was scanned at 750―1100 nm, and its first-order derivative spectrum were obtained from the original spectrum. The values of derivative selected at 995 nm were used for determination. It was proved that Vc could quickly react with Folin-Ciocalteau reagent within 5 min and the product was quite stable for a long time. The conditions required for this method is not very complicated, its precision and accuracy are similar to those of the iodometric titration described in Chinese Pharmacopoeia, and the limit of detection is 0.312 μg/mL. The determination of the results of vitamin C tablet, pill, and injection demonstrates that this method has wide pharmaceutical applications. | MENG Qing-fan TENG Le-sheng JIANG Chao-jun An Jin-shuang LI Lei LU Jia-hui TENG Li-rong | 2008 | Chemical Research in Chinese Universities2008，24，1： | 3 |
| 8 | Fiber-reinforced composites in milling and grinding:machining bottlenecks and advanced strategies显示文摘Fiber-reinforced composites have become the preferred material in the fields of aviation and aerospace because of their high-strength performance in unit weight.The composite components are manufactured by near netshape and only require finishing operations to achieve final dimensional and assembly tolerances.Milling and grinding arise as the preferred choices because of their precision processing.Nevertheless,given their laminated,anisotropic,and heterogeneous nature,these materials are considered difficult-to-machine.As undesirable results and challenging breakthroughs,the surface damage and integrity of these materials is a research hotspot with important engineering significance.This review summarizes an up-to-date progress of the damage formation mechanisms and suppression strategies in milling and grinding for the fiber-reinforced composites reported in the literature.First,the formation mechanisms of milling damage,including delamination,burr,and tear,are analyzed.Second,the grinding mechanisms,covering material removal mechanism,thermal mechanical behavior,surface integrity,and damage,are discussed.Third,suppression strategies are reviewed systematically from the aspects of advanced cutting tools and technologies,including ultrasonic vibration-assisted machining,cryogenic cooling,minimum quantity lubrication(MQL),and tool optimization design.Ultrasonic vibration shows the greatest advantage of restraining machining force,which can be reduced by approximately 60%compared with conventional machining.Cryogenic cooling is the most effective method to reduce temperature with a maximum reduction of approximately 60%.MQL shows its advantages in terms of reducing friction coefficient,force,temperature,and tool wear.Finally,research gaps and future exploration directions are prospected,giving researchers opportunity to deepen specific aspects and explore new area for achieving high precision surface machining of fiber-reinforced composites. | Teng GAO Yanbin ZHANG Changhe LI Yiqi WANG Yun CHEN Qinglong AN Song ZHANG Hao Nan LI Huajun CAO Hafiz Muhammad ALI Zongming ZHOU Shubham SHARMA | 2022 | Frontiers of Mechanical Engineering2022，17，2： | 3 |
| 9 | A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle显示文摘Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength. | Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye | 2021 | Bioactive Materials2021，6，7： | 3 |
| 10 | Preparation and Kinetics of a Novel Glutathione Peroxidase Mimic——Selenium-modified Hyaluronic Acid显示文摘A selenium-modified hyaluronic acid(HA) compound(SeHA) was synthesized as a mimic of glutathione peroxidase(GPX). IR and NMR spectra of SeHA predict that the —CH2OH group of the N-acetyl-D-glucosamine in HA was modified by group —SeH. There are averagely 152 —SeH groups in one SeHA molecule. The GPX activities are 103.88, 32.15 and 152.71 U/μmol, respectively, when the substrates were H2O2, BuOOH and CuOOH. Ping-pong mechanism was observed in the steady-state kinetic studies of the reactive oxygen species(ROS) consuming reaction. Result of reactions of SeHA with free radical capturer 2,6-di-tert-butyl-4-methylphenol(BHT) shows that the catalysis is based on a non-free radical-mechanism and the SeHA can not be inhibited by iodoacetate, an enzyme inhibitor. | CHEN Jia HONG Shui-sheng AN Yang JIANG Guang-zhi ZHANG Bo-xun FANG Xiang-yang LIU Lan-ying TENG Li-rong | 2007 | Chemical Research in Chinese Universities2007，23，3： | 2 |
| 11 | Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial显示文摘It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart disease.Here,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and placebo.After performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by DII.Furthermore,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol metabolism.We assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear regression.Our study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target drug.Modular methods facilitate the discovery of network pharmacologicalmechanisms and the advancement of precision medicine.(ClinicalTrials.gov identifier:NCTO1681316). | Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua Li Ying Xiao You-Zhi Hu Xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li Jian-Cong Tan Yang Lin Ya-Bin Zhou Jian-Fei Yang Guo-Qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu Jian-Xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing Li Fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 12 | Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice显示文摘Transposable elements(TEs)constitute the most abundant portions of plant genomes and can dramatically shape host genomes during plant evolution.They also play important roles in crop domestication.However,whether TEs themselves are also selected during crop domestication has remained unknown.Here,we identify an active long terminal repeat(LTR)retrotransposon,HUO,as a potential target of selection during rice domestication and breeding.HUO is a low-copy-number LTR retrotransposon,and is active under natural growth conditions and transmitted through male gametogenesis,preferentially inserting into genomic regions capable of transcription.HUO exists in all wild rice accessions and about half of the archaeological rice grains(1200–7000 years ago)and landraces surveyed,but is absent in almost all modern varieties,indicating its gradual elimination during rice domestication and breeding.Further analyses showed that HUO is subjected to strict gene silencing through the RNA-directed DNA methylation pathway.Our results also suggest that multiple HUO copies may trigger genomic instability through altering genome-wide DNA methylation and small RNA biogenesis and changing global gene expression,resulting in decreased disease resistance and yield,coinciding with its elimination during rice breeding.Together,our study suggests that negative selection of an active retrotransposon might be important for genome stability during crop domestication and breeding. | Yu Peng Yingying Zhang Yijie Gui Dong An Junzhong Liu Xun Xu Qun Li Junmin Wang Wen Wang Chunhai Shi Longjiang Fan Baorong Lu Yiwen Deng Sheng Teng Zuhua He | 2019 | Molecular Plant2019，12，10： | 2 |
| 13 | Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF- α , NF- κ Bp65, IL-6) in TNBS-Induced Colitis in Rats显示文摘 | Yan-Hong Zhou Jie-Ping Yu Yi-Fei Liu Xiao-Jun Teng Mei Ming Peng Lv Ping An Shi-Quan Liu Hong-Gang Yu | 2006 | Mediators of Inflammation2006，，： | 1 |
| 14 | Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells显示文摘 | Shunchao Yan Xiujuan Qu Chong’an Xu Zhitu Zhu Lingyun Zhang Ling Xu Na Song Yuee Teng Yunpeng Liu | 2012 | Journal of Cancer Research and Clinical Oncology2012，，8： | 1 |
| 15 | Pretreatment with the total fla- vone glycosides of Flos Abelmoschus manihot and hyperoside pre- vents glomerular podocyte apoptosis in streptozotocin-induced dia- betic nephropathy 显示文摘 | Zhou L An X F Teng S C | 2012 | J Med Food2012，15，5： | 1 |
| 16 | Evolution of mammalian and avian bomavirus-es 显示文摘 | He M An TZ Teng CB | 2014 | Mol Phylogenet Evol2014，，79： | 1 |
| 17 | Simulation model of reinforced concrete显示文摘 | TENG Tsoliang CHU Yi'an CHANG Fwu'an | 2004 | Cement and Concrete Research2004，34，11： | 1 |
| 18 | Enhanced photo electrochemical sensor based on ZnO-SnO2 composite nanotubes 显示文摘 | AN X TENG F ZHANG P | 2014 | Journal of alloys & compounds2014，614，： | 1 |
| 19 | Simulation model of reinforced concrete显示文摘 | TENG Tsoliang CHU Yi'an CHANG Fwu'an | 2004 | Cement and ConcreteResearch2004，34，11： | 1 |
| 20 | Pretreatment with the total flavone glycosides of Flos Abelmoschus manihot and hyperoside prevents glomerular podocyte apoptosis in streptozotocin- induced diabetic nephropathy显示文摘 | Zhou L An XF Teng SC | 2012 | J Med Food2012，15，5： | 1 |
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