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| 1 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 2 | Effect of sampling strategy on estimation of fine-scale spatial genetic structure in Androsace tapete (Primulaceae),an alpine plant endemic to Qinghai-Tibetan Plateau显示文摘The fine-scale spatial genetic structure(SGS)of alpine plants is receiving increasing attention,from which seed and pollen dispersal can be inferred.However,estimation of SGS may depend strongly on the sampling strategy,including the sample size and spatial sampling scheme.Here,we examined the effects of sample size and three spatial schemes,simple-random,line-transect,and random-cluster sampling,on the estimation of SGS in Androsace tapete,an alpine cushion plant endemic to Qinghai-Tibetan Plateau.Using both real data and simulated data of dominant molecular markers,we show that:(i)SGS is highly sensitive to sample strategy especially when the sample size is small(e.g.,below 100);(ii)the commonly used SGS parameter(the intercept of the autocorrelogram)is more susceptible to sample error than a newly developed Sp statistic;and(iii)the random-cluster scheme is susceptible to obvious bias in parameter estimation even when the sample size is relatively large(e.g.,above 200).Overall,the line-transect scheme is recommendable,in that it performs slightly better than the simple-random scheme in parameter estimation and is more efficient to encompass broad spatial scales.The consistency between simulated data and real data implies that these findings might hold true in other alpine plants and more species should be examined in future work. | Li-Yan ZENG Ling-Li XU Shao-Qing TANG Tashi TERSING Yu-Peng GENG Yang ZHONG | 2010 | Journal of Systematics and Evolution2010，48，4： | 7 |
| 3 | Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro显示文摘瞄准:Pseudolaric 酸 B (PAB ) ,从根孤立的 diterpene 酸金钱松属 kaempferi Gordon 吠叫,出现了经由导致 apoptosis 在几根癌症房间线跟随的房间周期拘捕施加反肿瘤效果。这里,我们报导 PAB 在人的肺癌症 A549 房间导致了一场有丝分裂的大祸,没有 apoptosis 或 necrosis.Methods,它导致了老朽:三根人的肺癌症房间线(A549, H460 和 H1299 房间) 被检验。细胞生长抑制与 MTT 试金被估计。房间周期分发用流动 cytometer 被决定。房间原子形态学在一台荧光显微镜下面被观察。衰老的房间用 SA-β 被检测;染色的女郎。Apoptotic 和衰老的蛋白质表示用西方的污点分析被检验。在房间的 p53 和 p21 的表示是由 siRNAs.Results 的 downregulated:有 PAB 的治疗(5-80 μ mol/L ) 在剂量依赖者和时间依赖者礼貌禁止了 A549 房间的生长。有 PAB 的延长治疗(20 μ mol/L ) 在白天 1 点的引起的 G 2/M 拘捕从白天 2 由有丝分裂的大祸列在后面,它最后导致了在天之间的房间老朽 3 和 4 没有房间死亡(apoptosis 或坏死) 。有 siRNA 的 p53 表示击倒在 A549 房间的显著地压制的导致 PAB 的老朽(p53 野) 。而且,导致 PAB 的老朽也在人的肺癌症 H460 房间被观察(p53 野) ,然而并非在人的肺癌症 H1299 房间(p53 0 ).Conclusion:对在 vitro 的人的肺癌症 A549 房间的 PAB 的反肿瘤行动通过 p53 小径的激活包含老朽的正式就职。 | Guo-dong YAO Jing YANG Qiang LI Ye ZHANG Min QI Si-miao FAN Toshihiko HAYASHI Shin-ichi TASHI RO Satoshi ONODERA Takashi IKEJIMA | 2016 | Acta Pharmacologica Sinica2016，37，7： | 5 |
| 4 | Memristor bridge-based low pass filter for image processing显示文摘This paper highlights the memristor bridge-based lowpass filter (LPF) and improved image processing algorithms along with a novel adaptive Gaussian filter for denoising image and a new Gaussian pyramid for scale invariant feature transform (SIFT). First, a novel kind of LPF based on the memristor bridge is designed, whose cut-off frequency and other traits are demonstrated to change with different time and memristance. In light of the changeable parameter of the memristor bridge-based LPF, a new adaptive Gaussian filter and an improved SIFT algorithm are presented. Finally, experiment results show that the peak signalto- noise ratio (PSNR) of our denoising is bettered more than 2.77 dB compared to the corresponding of the traditional Gaussian filter, and our improved SIFT performances including the number of matched feature points and the percent of correct matches are higher than the traditional SIFT, which verifies feasibility and effectiveness of our algorithm. | YU Yongbin YANG Nijing YANG Chenyu NYIMA Tashi | 2019 | Journal of Systems Engineering and Electronics2019，30，3： | 4 |
| 5 | Geographical distribution of the incidence of gastric cancer in Bhutan显示文摘AIM: To estimate the prevalence of gastric cancer(GC) in a cohort of patients diagnosed with GC and to compare it with patients diagnosed with all other types of gastro-intestinal(GI) cancer during the same period.METHODS: Between 2008 and 2013,five-year period,the medical records of all GI cancer patients who underwent medical care and confirm diagnosis of cancer were reviewed at the National Referral Hospital,Thimphu which is the only hospital in the country where surgical and cancer diagnosis can be made. Demographic information,type of cancer,and the year of diagnosis were collected.RESULTS: There were a total of 767 GI related cancer records reviewed during the study period of which 354(46%) patients were diagnosed with GC. There were 413 patients with other GI cancer including; esophagus,colon,liver,rectum,pancreas,gall bladder,cholangiocarcinoma and other GI tract cancers. The GC incidence rate is approximately 0.9/10000 per year(367 cases/5years per 800000 people). The geographic distribution of GC was the lowest in the south region of Bhutan 0.3/10000 per year compared to the central region 1.4/10000 per year,Eastern region 1.2/10000 per year,and the Western region 1.1/10000 per year. Moreover,GC in the South part was significantly lower than the other GI cancer in the same region(8% vs 15%; OR = 1.8,95%CI: 1.3-3.1,P = 0.05). Among GC patients,38% were under the age of 60 years,mean age at diagnosis was 62.3(± 12.1) years with male-to-female ratio 1:0.5. The mean age among patients with all other type GI cancer was 60 years(± 13.2) and male-tofemale ratio of 1:0.7. At time of diagnosis of GC,342(93%) were at stage 3 and 4 of and by the year 2013; 80(23%) GC patients died compared to 31% death among patients with the all other GI cancer(P = 0.08).CONCLUSION: The incidence rate of GC in Bhutan is twice as high in the United States but is likely an underestimate rate because of unreported and undiagnosed cases in the villages. The high incidence of GC in Bhutan could be attributed to the high prevalence of Helicobacter pylori infection that we previously reported. The lowest incidence of GC in Southern part of the country could be due to the difference in the ethnicity as most of its population is of Indian and Nepal origin. Our current study emphasizes on the importance for developing surveillance and prevention strategies for GC in Bhutan. | Tashi Dendup James M Richter Yoshio Yamaoka Kinley Wangchuk Hoda M Malaty | 2015 | World Journal of Gastroenterology2015，21，38： | 4 |
| 6 | Discovery of a high-altitude ecotype and ancient lineage of Arabidopsis thaliana from Tibet显示文摘Arabidopsis thaliana(A.thaliana)has long been a model species for dicotyledon study,and was the first flowering plant to get its genome completed sequenced[1].Although most wild A.thaliana are collected in Europe,several studies have found a rapid A.thaliana west-east expansion from Central Asia[2].The Qinghai-Tibet Plateau(QTP)is close to Central Asia and known for its high alti- | Liyan Zeng Zhuoya Gu Min Xu Ning Zhao Weidong Zhu Takahiro Yonezawa Tianmeng Liu Lha Qiong Tashi Tersing Lingli Xu Yang Zhang Rongyan Xu Ningyu Sun Yanyan Huang Jiankun Lei Liang Zhang Feng Xie Fang Zhang Hongya Gu Yupeng Geng Masami Hasegawa Ziheng Yang M. James C. Crabbe Fan Chen Yang Zhong | 2017 | Science Bulletin2017，62，24： | 3 |
| 7 | Exploring Temporal Activity Patterns of Urban Areas Using Aggregated Network-driven Mobile Phone Data:A Case Study of Wuhu,China显示文摘The increasing availability of data in the urban context(e.g.,mobile phone,smart card and social media data)allows us to study urban dynamics at much finer temporal resolutions(e.g.,diurnal urban dynamics).Mobile phone data,for instance,are found to be a useful data source for extracting diurnal human mobility patterns and for understanding urban dynamics.While previous studies often use call detail record(CDR)data,this study deploys aggregated network-driven mobile phone data that may reveal human mobility patterns more comprehensively and can mitigate some of the privacy concerns raised by mobile phone data usage.We first propose an analytical framework for characterizing and classifying urban areas based on their temporal activity patterns extracted from mobile phone data.Specifically,urban areas’diurnal spatiotemporal signatures of human mobility patterns are obtained through longitudinal mobile phone data.Urban areas are then classified based on the obtained signatures.The classification provides insights into city planning and development.Using the proposed framework,a case study was implemented in the city of Wuhu,China to understand its urban dynamics.The empirical study suggests that human activities in the city of Wuhu are highly concentrated at the Traffic Analysis Zone(TAZ)level.This large portion of local activities suggests that development and planning strategies that are different from those used by metropolitan Chinese cities should be applied in the city of Wuhu.This article concludes with discussions on several common challenges associated with using network-driven mobile phone data,which should be addressed in future studies. | ZHANG Shanqi YANG Yu ZHEN Feng LOBSANG Tashi | 2020 | Chinese Geographical Science2020，30，4： | 2 |
| 8 | Memristive network-based genetic algorithm and its application to image edge detection显示文摘This paper proposes a mem-computing model of memristive network-based genetic algorithm(MNGA)by building up the relationship between the memristive network(MN)and the genetic algorithm(GA),and a new edge detection algorithm where image pixels are defined as individuals of population.First,the computing model of MNGA is designed to perform mem-computing,which brings new possibility of the hardware implementation of GA.Secondly,MNGA-based edge detection integrating image filter and GA operator deployed by MN is proposed.Finally,simulation results demonstrate that the figure of merit(FoM)of our model is better than the latest memristor-based swarm intelligence.In summary,a new way is found to build proper matching of memristor to GA and aid image edge detection. | YU Yongbin YANG Chenyu DENG Quanxin NYIMA Tashi LIANG Shouyi ZHOU Chen | 2021 | Journal of Systems Engineering and Electronics2021，32，5： | 2 |
| 9 | Interpopulation variability of rhizome essential oils in Rhodiola crenulata from Tibet and Yunnan, China显示文摘 | Yidong Lei Peng Nan Tashi Tsering Li Wang Shiping Liu Yang Zhong | 2003 | Biochemical Systematics and Ecology2003，，6： | 1 |
| 10 | Seliciclib in malignancies显示文摘 | ALSS I T TASHI T GANTI A K | 2009 | Expert Opin Inv Drug2009，18，12： | 1 |
| 11 | Chemical Composition of the Essential Oils of Two Rhodiola Species from Tibet显示文摘 | YIDONG LEI PENG NAN TASHI TSERING | 2003 | Zeitschrift for Naturforschung C :Journal of Biosciences2003，58，： | 1 |
| 12 | Interpopulation variability of rhizome essentialoils in Rhodiola crenulata from Tibet and Yun-nan,China显示文摘 | Yidong L Peng N Tashi T | 2004 | Biochemical Systematics and Ecology2004，32，6： | 1 |
| 13 | Chemical Composi2tion of the EssentialOils of Two Rhodiola Species from Tibet 显示文摘 | Yidong Lei Peng Nan Tashi Tsering | 2003 | Zeitschrift ftir Naturforsehung C: Journal of B iosciences2003，58，16： | 1 |
| 14 | Epidemiology of H elicobacter pylori in B hutan: The Role of Environment and Geographic Location显示文摘 | Dorji Dorji Tashi Dendup Hoda M. Malaty Kinley Wangchuk Deki Yangzom James M. Richter | 2014 | Helicobacter2014，，1： | 1 |
| 15 | The finite element simulation of Lamb wave propagation in a cracked structure with coupled filed elements显示文摘 | TASHI S ABEDIAN A KHAJEHTOURIAN | 2012 | Advanced Mate- rials Research2012，，： | 1 |
| 16 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 17 | Isolated Gastric Tuberculosis Presenting as Massive Hematemesis: Report of a Case显示文摘 | Jai Dev Wig Kim Vaiphei Motup Tashi Rakesh Kochhar | 2000 | Surgery Today2000，，10： | 1 |
| 18 | Design and machining of the epicycloid planet gear of cy- cloid drives显示文摘 | Lai Tashi | 2006 | The International Journal of Advanced Manufactur- ing Technology2006，28，7： | 1 |
| 19 | Geometric design of roller drives with cylindrical meshing elements显示文摘 | Lai Tashi | 2005 | Mechanism and Machine Theory2005，40，1： | 1 |
| 20 | Quality quandaries: A gage R&R study in a hospital 显示文摘 | Tashi P E | 2010 | Quality Engineering2010，，22： | 1 |
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