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| 1 | ELE restrains empty glumes from developing into lemmas显示文摘Although there is evident homology among reproductive organs when comparing Poaceae (grass) and eudicots, the identity of grass specific organs, such as lodicules, palea, lemma, and glumes has been the subject of a vast and largely inconclusive discussion. Here we provide some direct evidence to support the idea that the empty glumes of rice (Oryza sativa) are counterparts of lemmas. We show that the development of empty glumes is regulated by ELE (elongated empty glume), which belongs to a plant specific novel gene family. Mutations at the ELE locus cause elongated empty glumes, which mimic the lemmas and have the epidermal morphology of lemmas with four or five vascular bundles. As a nuclear-localized gene, ELE is specifically expressed at the empty glumes of immature spikelets, and its ectopic expression causes many floral development defects, including lemma-like palea, extra palea-like structures, elongated lodicules, extra stamens and stigmas. Our result suggests that empty glumes are lemmas of the sterile florets located at the lateral side of the rice spikelet, and ELE acts as a regulator restraining its growth to maintain its small size in wild-type plants. | Lilan Hong Qian Qian Keming Zhu Ding Tang Zejun Huang Ling Gao Ming Li Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，2： | 11 |
| 2 | Tectonic Evolution of the Middle Frontal Area of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘由分析平衡的生气的节和 Longmen 山戳带的沉淀历史,中国,我们断定它经历了五个构造阶段:(1 ) 形成阶段(T 3 x ) Longmen 的缩影,山,早 Indosinian 运动,和 Anxian 构造运动创造了 Longmen 山;(2 ) 稳定的构造阶段(更弱的构造运动导致了 Longmen 山戳带的 J 1) 稍微正在被高举并且稍微减退低岬盆;(3 ) 强烈构造阶段(J2.3 ) ,也就是早 Yanshan 运动;(4 ) 连续构造运动(K-E ) ,也就是迟了的 Yanshan 运动和早喜玛拉雅的运动;并且(5 ) Longmen 山(N-Q ) 的形成,也就是晚喜玛拉雅的运动。在那些构造变丑阶段期间, Anxian 运动和喜玛拉雅的运动在 Longmen 山的形成起了重要作用。喜玛拉雅的运动影响了 Longmen 山大多数;阶层强烈地推进了并且严重地被侵蚀。因为一些越过水坝落下的水被推,在 Longmen 山戳带的中间的部分有某 klippes 在以后向东南构造变丑。 | JIN Wenzheng TANG Liangjie YANG Keming WAN Guimei Lü Zhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 3 | The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells显示文摘Neogambogic 酸(NGA ) ,在 garcinia 的活跃成分,能在 anticancer 效果禁止一些稳固的肿瘤和结果的生长。我们假设那 NGA 可能为人的乳癌房间线 MCF-7 房间的增长的抑制负责。在 vitro 调查它的 anticancer 机制, MCF-7 房间与 NGA 的各种各样的集中被对待。试金显示出的 MTT (甲基 thiazolyl tetrazolum ) 的结果有 NGA 的那治疗显著地以一种剂量依赖者方式减少了 MCF-7 房间的增长。NGA 能增加 anti-apoptotic 蛋白质 Bcl-2 的表示由 mitochondrial transmembrane 损坏伴随了的 apoptosis 相关的蛋白质 FasL, caspase-3, caspase-8, caspase-9,和 Bax 和减少的表示。MCF-7 房间上的 NGA 的 antiproliferative 效果由于 Fas/FasL 和细胞色素 C 小径的 G0/G1 拘捕,增加的 apoptosis 和激活。这些结果提供重要卓见进 NGA 通过损害乳癌房间的增长的细胞、分子的机制。 | Keming Wang Yuhong Tang Ming Sun Binbin Lu Hongqin Zhu Ou Ji Qun Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 9 |
| 4 | Contrasting elevational diversity patterns for soil bacteria between two ecosystems divided by the treeline显示文摘Above- and below-ground organisms are closely linked, but how elevational distribution pattern of soil microbes shifting across the treeline still remains unknown. Sampling of 140 plots with transect, we herein investigated soil bacterial distribution pattern from a temperate forest up to a subalpine meadow along an elevational gradient using Illumina sequencing. Our results revealed distinct elevational patterns of bacterial diversity above and below the treeline in responding to changes in soil conditions:a hollow elevational pattern in the forest(correlated with soil temperature, pH, and C:N ratio) and a significantly decreasing pattern in the meadow(correlated with soil pH, and available phosphorus). The bacterial community structure was also distinct between the forest and meadow, relating to soil pH in the forest and soil temperature in the meadow. Soil bacteria did not follow the distribution pattern of herb diversity, but bacterial community structure could be predicted by herb community composition. These results suggest that plant communities have an important influence on soil characteristics, and thus change the elevational distribution of soil bacteria. Our findings are useful for future assessments of climate change impacts on microbial community. | Guixiang Li Guorui Xu Congcong Shen Yong Tang Yuxin Zhang Keming Ma | 2016 | Science China(Life Sciences)2016，59，11： | 9 |
| 5 | Differential Tectonic Deformation of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘地调查和地震的节解释证明 Longmen 山戳带有明显的微分变丑:带状配列,分割和层化。带状配列意味着那,从 NW 到 NE, Longmen 山戳带能被划分成 Songpan-Garz ê构造的带,可锻的变丑带,基础深奥的戳带,正面的褶层戳带,和低岬消沉。它能向南向北被划分成五个片断从到的分割工具:北片断, Anxian 转移地区,中心片断, Guanxian 转移地区和南部的片断。层化意味着分开层在侧面划分结构的式样。在 Longmen 山戳带的分开层能被分类进三个范畴:深水平的分开层包括外壳披风系统分开层, intracrustal 分开层,和 Presinian 系统基础分开层;中间级的分开层包括寒武纪奥陶纪的分开层,志留纪分开层,等等;并且浅水平的分开层,包括的上面的三叠纪的 Xujiahe 形成分开层和侏罗记分开层。多水平分开层在塑造和 Longmen 山戳带的进化上有很重要的效果。 | TANG Liangjie YANG Keming JIN Wenzheng WAN Guimei LüZhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 6 |
| 6 | OsAM1 is required for leptotene-zygotene transition in rice显示文摘发生在成熟分裂的发作的事件充分没被阐明。在现在的学习, OsAM1 被基于地图的克隆在米饭(Oryza sativa L.) 识别。OsAM1, Arabidopsis SWI1 的一个相当或相同的事物和玉米 AM1,与一个卷卷领域把蛋白质编码为它的中央区域。在 Osam1 异种,花粉母亲房间在 leptotene 被逮捕,证明 OsAM1 为 leptotene-zygotene 转变被要求。Immunocytological 分析表明 OsAM1 在早前期作为 foci 存在我 meiocytes。很微弱的 OsREC8 foci 在 Osam1 异种坚持了,显示 OsAM1 没为 OsREC8 的起始的 meiotic 招募被要求。当 OsAM1 不在时,包括 PAIR2, ZEP1 和 OsMER3,许多另外的批评 meiotic 部件不能正确地被安装到染色体上。在 pair2, Osmer3 和 zep1 异种,相反, OsAM1 能通常被装载,建议 OsAM1 起造在成熟分裂的开始的合适的染色体结构里的一个基本作用。 | Lixiao Che Ding Tang Kejian Wang Mo Wang Keming Zhu Hengxiu Yu Minghong Gu Zhukuan Cheng | 2011 | Cell Research2011，21，4： | 4 |
| 7 | Effect of combined medicated thread moxibustion plus needle picking therapy of Zhuang nationality medicine on antioxidant levels in a rat model of sciatica显示文摘OBJECTIVE: To investigate the effect and underlying mechanisms of combined medicated thread moxibustion therapy plus needle picking therapy of Zhuang nationality medicine on antioxidant levels in a rat model of sciatica.METHODS: One hundred Wistar rats, of specific pathogen free level, were randomly divided into five groups: normal control group, model group,medicated thread moxibustion group, needle picking group, and combination group. Each group contained 20 rats. In the model, medicated thread moxibustion, needle picking, and combination groups,sciatica models were established through chronicconstriction injury of the sciatic nerve. After the model was established, the rats in the medicated thread moxibustion, needle picking, and combination groups were given the corresponding therapies for 21 days. The control and model groups received no treatment. Reactive oxygen species, superoxide dismutase, malondialdehyde, and total antioxidant capacity changes were determined.Nicotinamide adenine dinucleotide phosphate(NADPH) oxidase subunit NADPH oxidases 4(NOX4) m RNA expression and the morphology of cells were observed to detect apoptosis of gamma-aminobutyric acid ergic(GABAergic) neurons.RESULTS: Compared with control group, reactive oxygen species and malondialdehyde levels rose significantly in the model group(P < 0.01), while superoxide dismutase and total antioxidant capacity levels were lowered(P < 0.05). Compared with the model group, reactive oxygen species and malondialdehyde decreased in the needle picking group(P < 0.05), while superoxide dismutase levels were increased(P < 0.05); reactive oxygen species and malondialdehyde significantly decreased in the combination group(P < 0.01). In addition, the model group had higher NOX4 m RNA expression than that of the control group(P < 0.05), and the combination group had lower expression levels than that of the model group(P < 0.05). Apoptosis of GABAergic neurons was observed in the model group, and was attenuated after combined therapy.CONCLUSION: The medicated thread moxibustion therapy plus needle picking therapy of Zhuang nationality medicine can prevent oxidative damage in the rat model of sciatica via down-regulating NOX4 expression, improving antioxidant capacity, and in-hibiting the oxidative damage pathway of GABAergic neurons. | Tang Hanqing Zheng Jianyu Li Tianzi Li Keming Li Xiaohua Dou Xibin Huang Chunchuan Liang Ye | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 4 |
| 8 | The geometric simulation and analysis of the blind growth fold in the overthrust belt of the southern section of the frontier Longmen Mt.during Late Triassic显示文摘The seismic profiles processed by high-resolution display that a blind growth fault-bend fold emerges in depth of seismic exploration area in Dayi in the southern section of the frontier Longmen Mt.This paper presents a detailed structural interpretation to seismic section,then describes the deformed geometry related to the pre-growth strata,the growth strata and the post-growth strata on both limbs of the fold.The computer geometric simulation,based on the model of fault-bend fold,is utilized to stimulate the geometry of the blind growth fold at different sedimentation rates in Dayi.These structural features are subsequently extracted and compared with the actual seismic reflection section.Our research suggests that a low angle overthrust formed during Late Triassic also appears in the southern section of the frontier Longmen Mt.The event of structure took place at the depositional stage of a portion of the middle and upper fourth member of Xujiahe Formation(T3x4),which corresponds to thrusting in the northern section of the frontier Longmen Mt.However,the thrusting displacement here is smaller than one of the northern section. | CHEN Wei YANG KeMing LI ShuBin JIAN GaoMing TANG Jin ZHAO Yiao SU Qian | 2009 | Chinese Science Bulletin2009，54，8： | 3 |
| 9 | A novel strategy for mining frequent closed itemsets in data streams 显示文摘 | Tang Keming Dai Caiyan Chen Ling | 2012 | Journal of Computers2012，7，7： | 1 |
| 10 | Study on the faults in Longmen Mountain Thrust Belt, western Sichuan foreland basin,China 显示文摘 | Wan Guimei Tang Liangjie Yang Keming | 2008 | Journal of China University of Geosciences2008，19，6： | 1 |
| 11 | Transfer zones of Longmen Mountain thrust beh, SW China 显示文摘 | Jin Wenzheng Tang Liangjie Yang Keming | 2009 | Geosciences Journal2009，13，1： | 1 |
| 12 | MXene-GaN van der Waals metal-semiconductor junctions for high performance multiple quantum well photodetectors显示文摘A MXene-GaN-MXene based multiple quantum well photodetector was prepared on patterned sapphire substrate by facile drop casting.The use of MXene electrodes improves the responsivity and reduces dark current,compared with traditional Metal-Semiconductor-Metal(MSM)photodetectors using Cr/Au electrodes.Dark current of the device using MXene-GaN van der Waals junctions is reduced by three orders of magnitude and its noise spectral intensity shows distinct improvement compared with the traditional Cr/Au–GaN–Cr/Au MSM photodetector.The improved device performance is attributed to low-defect MXene-GaN van der Waals interfaces.Thanks to the high quality MXene-GaN interfaces,it is possible to verify that the patterned substrate can locally improve both light extraction and photocurrent collection.The measured responsivity and specific detectivity reach as high as 64.6 A/W and 1.93×1012 Jones,respectively,making it a potential candidate for underwater optical detection and communication.The simple fabrication of MXene-GaN-MXene photodetectors spearheaded the way to high performance photodetection by combining the advantages of emerging 2D MXene materials with the conventional III-V materials. | Lingzhi Luo Yixuan Huang Keming Cheng Abdullah Alhassan Mahdi Alqahtani Libin Tang Zhiming Wang Jiang Wu | 2021 | Light(Science & Applications)2021，10，10： | 1 |
| 13 | Segmentation of the Longmen Mountains thrust belt, Western Sichuan Foreland Basin, SW China显示文摘 | Wenzheng Jin Liangjie Tang Keming Yang Guimei Wan Zhizhou Lü | 2009 | Tectonophysics2009，，1： | 1 |
| 14 | ERECT PANICLE2 Encodes a Novel Protein That Regulates Panicle Erectness in Indica Rice显示文摘 | Zhu Keming Tang Ding Yan Changjie Chi Zhengchang Yu Hengxiu Chen Jianmin Liang Jiansheng Gu Minghong Cheng Zhukuan | 2010 | Genetics2010，，2： | 1 |
| 15 | Development and application of molecular markers for TSW(thousand-seed weight)related gene BnaGRF7.C02 in Brassica napus显示文摘Brassica napus L(rapeseed)is one of the most important oil crops with large cultivated area in China.Seed size and seed weight play crucial roles for yield and harvest.In this study,a type of 15 bp-deletion in BnaGRF7.CO2 coding region was identified through sequence alignment of BnaGRF7.C02 in 42 rapeseed varieties,and associ-ation analysis indicated that the 15 bp-deletion was related to the rapeseed Thousand-Seed Weight(TSW)phenotype.Furthermore,we developed two InDel markers to identify this 15 bp InDel.The tissue-specific expression patterns showed that BnaGRF7.C02 prominently expressed in the late stage of seed development.These findings may assist in InDel markers-based breeding efforts to select higher TWS varieties and improve the crop yield of B.nqpus. | Jing Zhao Chanyu Jin Rui Geng Yixuan Xue Minqiang Tang Keming Zhu Yulong Li Duoduo Wang Shengyi Liu Xiaoli Tan | 2021 | Oil Crop Science2021，6，3： | 0 |
| 16 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 17 | Hemodynamic Shear Stress Regulates the Survival of Circulating Tumour Cells Through Piezo1-Actomyosin-Mediated YAP/TAZ Nuclear Translocation显示文摘It is critical to combat tumor metastasis by eradicating disseminated tumor cells in any step during the metastasis process.After entering the blood circulation system,tumor cells are in suspension and experience considerable levels of fluid shear stress.However,the influence of hemodynamic shear stress on the survival of CTCs and the underlying mechanotransduction mechanisms remain unclear.This study shows that fluid shear stress can eliminate the majority of CTCs and the viability of suspended tumor cells depends on the stress magnitude,indicating that tumor cells can sense and respond to fluid shear stress.Mechanistically,the expression of Piezo1 but not Piezo2 is greatly upregulated in suspended tumor cells after shear stress treatment.Inhibiting/activating Piezo1 increases/decreases the viability of suspended tumor cells in shear flow,which depends on Piezo1-mediated calcium entry.These findings suggest that Piezo1 may be the major mechanosensor by which suspended tumor cells sense fluid shear stress.As the downstream effector of Piezo1,actomyosin in tumor cells is significantly activated under increasing shear stress.Its activity influences the survival of CTCs in shear flow and rescues the effects of Piezo1 on tumor cell survival,suggesting that hemodynamic shear stress regulates the survival of CTCs through Piezo1 mediated actomyosin activity.Importantly,fluid shear stress considerably up-regulates YAP/TAZ activity of suspended tumor cells and promotes their nuclear translocation in a magnitude-dependent manner.Inhibiting YAP/TAZ enhances the viability of suspended tumor cells in shear stress,while activating their activity decreases tumor cell survival,suggesting that YAP/TAZ activation promotes the apoptosis of suspended tumor cells,which is different from the findings that YAP/TAZ facilitates the survival of adherent cells to shear flow.Further,blocking the nuclear import of YAP/TAZ inactivates the sensation of suspended tumor cells to fluid shear flow and attenuates the dependence of tumor cell survival on different magnitudes of hemodynamic shear stress.The influence of Piezo1-actomyosin pathway on suspended tumor cells can be rescued by YAP/TAZ activity,suggesting that Piezo1-mediated signaling induces tumor cell apoptosis via nuclear translocation of YAP/TAZ.In addition,fluid shear stress can also activate the expressions of LATS1/2 and MST1/2 in Hippo pathway through Piezo1,which is known to inhibit YAP/TAZ activity.Silencing/activating LATS1/2 or MST1/2 inhibits/enhances the viability of CTCs under shear stress,the effects of which can be further rescued by YAP/TAZ.These findings suggest that the responses of suspended tumor cells to hemodynamic shear stress are partially mediated by Hippo signaling.After nuclear translocation,YAP/TAZ directly bind p73/PUMA,which further promotes the transcription of pro-apoptotic genes and induces the apoptosis of suspended tumor cells.In summary,these findings show that hemodynamic shear stress considerably influences the survival of CTCs in blood circulation.We have identified the calcium channel Piezo1 as a novel mechanosensor for the response of CTCs to fluid shear stress.Hemodynamic shear stress induces the apoptosis of suspended tumor cells through Piezo1-actomyosin-YAP/TAZ-p73/PUMA signaling,which is different from the mechanotranduction mechanisms for tumor cells in adherent.Therefore,this study has unveiled the novel mechanosensor of suspended CTCs in response to fluid shear stress and the subsequent mechanisms and identified Piezo1 and YAP/TAZ as the potential therapeutic targets,through which CTCs may be effectively eradicated in the vasculature to prohibit tumor metastasis. | Keming Li Ying XIN Kai Tang Youhua Tan | 2019 | 医用生物力学2019，34，A01： | 0 |
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