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| 1 | Rabeprazole vs esomeprazole in non-erosive gastro-esophageal reflux disease: A randomized, double-blind study in urban Asia显示文摘AIM:Gastro-esophageal reflux disease (GERD) is becoming increasingly common in Asia. Data on the efficacy of proton pump inhibitors in patients with non-erosive GERD (NERD)in Asia is lacking. This double-blind study compared the efficacy and safety of rabeprazole with esomeprazole in relief of symptoms in patients with NERD.METHODS: One hundred and thirty-four patients with reflux symptoms of NERD and normal endoscopy were randomized to receive rabeprazole 10 mg or esomeprazole 20 mg once daily for 4 wk. Symptoms were recorded in a diary and changes in severity of symptoms noted.RESULTS: At 4 wk of treatment, rabeprazole 10 mg and esomeprazole 20 mg were comparable with regards to the primary endpoint of time to achieve 24-h symptomfree interval for heartburn 8.5 d vs9 d and regurgitation 6 d vs 7.5 d. Rabeprazole and esomeprazole were also similarly efficacious in term of patient's global evaluation with 96% of patients on rabeprazole and 87.9% of patients on esomeprazole, reporting that symptoms improved(P=NS). Satisfactory relief of day- and night-time symptoms was achieved in 98% of patients receiving rabeprazole and 81.4% of patients receiving esomeprazole. Adverse events were comparable in both groups (P = NS).CONCLUSION: Rabeprazole 10 mg has a similar efficacy and safety profile in Asians with NERD as esomeprazole 20 mg. Further study is necessary to investigate whether the small differences between the two drugs seen in this study are related to the improved pharmacodynamicpro perties of rabeprazole. Both drugs were well tolerated. | KM Fock EK Teo TL Ang TS Chua TM Ng YL Tan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 2 | Zinc-Finger Protein145,Acting as an Upstream Regulator of SOX9,Improves the Differentiation Potential of Human Mesenchymal Stem Cel s for Cartilage Regeneration and Repair显示文摘 | Liu TM Guo XM Tan HS | | 0，，： | 1 |
| 3 | BpeAB OprB, a multi- drug efflux pump in gurkholderia pseudomallei显示文摘 | Chan YY Tan TM Ong YM etal | 2004 | Antimi crob Agents Chemother2004，48，4： | 1 |
| 4 | Pustular psoriasis exacerbated by pregnancy and controlled by cyclosporin A 显示文摘 | Finch TM Tan CY | 2000 | Br J Dermatol2000，142，3： | 1 |
| 5 | Inhibition of enterovirus 71 in virus-infected mice by RNA interference显示文摘 | Tan EL Tan TM Tak Kwong Chow V | | 0，，11： | 1 |
| 6 | High-pressure liquid chromatographic method for analysis of cephalosporins显示文摘 | Signs SA File TM Tan JS | 1984 | Antimierob Agents Chemother1984，26，5： | 1 |
| 7 | MELAS syndrome, diabetes, and thyroid disease: the role of mitochondrial oxidative stress 显示文摘 | Tan TM Caputo C Medici F etal | 2009 | Clin Endocrinol (Oxf)2009，70，2： | 1 |
| 8 | RNA interference against enterovirus 71 infection 显示文摘 | Sire AC Luhur A Tan TM Chow VT Poh CL | 2005 | Virology2005，341，1： | 1 |
| 9 | Quinolino-benzo- -di-hydroisoquindolium compounds derived from berberine: A newclass of highly selective ligands for G-quadruplex DNA in c-myconcogene显示文摘 | Ma Y Ou TM Tan JH | 2011 | European Journal of Medicinal Chemistry2011，46，5： | 1 |
| 10 | Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated effiux of cAMP and resistance to purine analogues显示文摘 | Lai L Tan TM | 2002 | Biochem J2002，361，3： | 1 |
| 11 | Lie detection by functional magnetic resonance imaging显示文摘 | Lee TM Liu HL Tan LH | 2002 | Hum Brain Mapp2002，15，3： | 1 |
| 12 | Management of community- acq-uired pneumonia: a focus on conversion from hospital to the ambulatory setting显示文摘 | Tan JS File TM Jr | 2003 | Am J Respir Med2003，2，5： | 1 |
| 13 | Ghrelin can bind to a species of high-density lipoprotein associated with paraoxonase显示文摘 | Beaumont NJ Skinner VO Tan TM | 2003 | J Biol Chem2003，278，11： | 1 |
| 14 | Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor 显示文摘 | Hackeng TM Sere KM Tans G | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 15 | Inhibition of enterovirus 71 invirus-infectedmice by RNA interference 显示文摘 | Tan EL Tan TM Kwong CV | 2007 | Mol Ther2007，15，11： | 1 |
| 16 | Inhibition of enterovirus 71 in virus-infected mice by RNA interference 显示文摘 | Tan EL Tall TM Tak Kwong Chow V | 2007 | Mol Ther2007，15，11： | 1 |
| 17 | Vascularization and morphological changes of tbe endplate after axial compression and distraction of the intervertebral disc显示文摘 | Hee TM Chuah TM Tan BHM | 2011 | Spine2011，36，7： | 1 |
| 18 | Effects of capsaicin on P-gP function and expression in Caco-2 cells显示文摘 | Tan TM Lim LY | 2006 | Biochemical pharmacology2006，71，12： | 1 |
| 19 | Inhibition of enterovirus 71 in virus-infected mice by RNA interference显示文摘 | Tan EL Tan TM Tak Kwong Chow V | 2007 | Mol Ther2007，15，11： | 1 |
| 20 | The role of atypical pathogens: Mycoplasma pneumoniae,Chlamydia pneumoniae,and Le- gionella pneumophila in respiratory infection 显示文摘 | File TM Tan JS Plouffe JF | 1998 | Infect Dis Clin North Am1998，12，3： | 1 |
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