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| 1 | 亚太地区炎症性肠病处理共识意见(一)显示文摘虽然目前亚太地区尚无炎症性肠病(IBD)的大规模流行病学资料,但一系列研究显示其发病率和患病率呈上升趋势,与西方国家相比仍呈滞后现象,溃疡性结肠炎(UC)的发病率仍较克罗恩病(CD)高。除地域差异外,在一些多民族国家中,IBD尚可见种族差异。亚太地区IBD的遗传背景有异于西方国家,如据报道该地区CD患者未检出NOD2/CARD15变异。一般而言,该地区IBD患者的临床过程似不如西方国家严重。亚太地区IBD的诊断存在一些特殊问题。如缺乏IBD诊断金标准,存在多种小肠结肠炎,与IBD临床表现相似,使鉴别诊断特别困难。迄今为止,亚太地区IBD的诊断标准多采用西方国家的诊断标准。诊断必须逐步排除非IBD的小肠结肠炎,确诊应有典型的组织学表现,某些患者需借助随访和诊断性治疗才能确诊。进一步研究IBD发病机制将有助于开发更好的诊断标记物。亚太地区IBD的治疗亦存在特殊问题。由于诊断困难,IBD患者常未能及时接受适当的药物治疗,但该地区仍广泛采用药物治疗方案。结合西方指南和本地经验可制定类似的处理原则,以利诱导缓解和维持缓解。提倡逐级使用基于病变范围、活动性和严重度的阶梯式治疗方案,对不同病例采用综合性、个体化的方法。随着对IBD发病机制和亚太地区IBD独特性的深入理解,合理、实用的药物治疗指南和应用生物制剂治疗将改善该地区IBD的治疗前景。 | 欧阳钦 Rakesh Tandon KL Goh 潘国宗 KM Fock Claudio Fiocchi SK Lam 萧树东 张虎 梁红亮 王玉芳 | 2006 | 胃肠病学2006，11，4： | 123 |
| 2 | 世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染显示文摘我非常高兴向大家推荐这份发展中国家幽门螺杆菌(H.priori)临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG Fock KM Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖 丛衍群 戴宁 | 2007 | 胃肠病学2007，12，1： | 85 |
| 3 | 胃食管反流病处置流程的亚太共识中关于难治性胃食管反流病和巴雷特食管的内容更新显示文摘大多数胃食管反流病( gastroesophageal reflux disease , GERD)属于非糜烂性胃食管反流病(NERD),其余则为糜烂性胃食管反流病,其严重程度不同,并发症多样,包括巴雷特食管(Barrett esophagus,BE)、食道狭窄和食道腺癌,所幸在亚太地区,这些并发症并不多见甚至罕见. 一般认为在2004 年前,亚洲人种与西方相比, GERD 并不常见. 但在2004年胃食管反流病处置流程的亚太共识中,发现在亚洲,这种疾病呈增长趋势,因此针对该地区对GERD诊断和处置措施的相关文献进行回顾复习. 随后,第二部共识也因GERD非典型的胃肠道外表现越来越多,而内镜和手术干预措施也越来越普及而发表. 目前,认为有必要对GERD处置流程进行第三次文献复习以阐明质子泵抑制剂( proton pump inhibitors,PPI)难治性GERD相关问题,回顾关于BE诊断的方法并对其筛查和随访中的价值提出新的推荐等级. | 王强 王一凡 杜植鹏 译张伟 仇明 fock km | 2016 | 中华胃食管反流病电子杂志2016，3，3： | 127 |
| 4 | 亚太地区炎症性肠病处理共识意见(二)显示文摘 | 欧阳钦 Rakesh Tandon KL Goh 潘国宗 KM Fock Claudio Fiocchi SK Lam 萧树东 张虎(翻译) 梁红亮(翻译) 王玉芳(翻译) 欧阳钦(审校) | 2006 | 胃肠病学2006，11，5： | 47 |
| 5 | Rabeprazole vs esomeprazole in non-erosive gastro-esophageal reflux disease: A randomized, double-blind study in urban Asia显示文摘AIM:Gastro-esophageal reflux disease (GERD) is becoming increasingly common in Asia. Data on the efficacy of proton pump inhibitors in patients with non-erosive GERD (NERD)in Asia is lacking. This double-blind study compared the efficacy and safety of rabeprazole with esomeprazole in relief of symptoms in patients with NERD.METHODS: One hundred and thirty-four patients with reflux symptoms of NERD and normal endoscopy were randomized to receive rabeprazole 10 mg or esomeprazole 20 mg once daily for 4 wk. Symptoms were recorded in a diary and changes in severity of symptoms noted.RESULTS: At 4 wk of treatment, rabeprazole 10 mg and esomeprazole 20 mg were comparable with regards to the primary endpoint of time to achieve 24-h symptomfree interval for heartburn 8.5 d vs9 d and regurgitation 6 d vs 7.5 d. Rabeprazole and esomeprazole were also similarly efficacious in term of patient's global evaluation with 96% of patients on rabeprazole and 87.9% of patients on esomeprazole, reporting that symptoms improved(P=NS). Satisfactory relief of day- and night-time symptoms was achieved in 98% of patients receiving rabeprazole and 81.4% of patients receiving esomeprazole. Adverse events were comparable in both groups (P = NS).CONCLUSION: Rabeprazole 10 mg has a similar efficacy and safety profile in Asians with NERD as esomeprazole 20 mg. Further study is necessary to investigate whether the small differences between the two drugs seen in this study are related to the improved pharmacodynamicpro perties of rabeprazole. Both drugs were well tolerated. | KM Fock EK Teo TL Ang TS Chua TM Ng YL Tan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 6 | Report of the Asia-pacific consensus on the management of gastroesophageal reflux disease 显示文摘 | Fock KM Talley N Hunt R | 2004 | J Gastroenterol Hepatol2004，19，3： | 1 |
| 7 | The diagnostic utility of narrow band imaging magnifying endoscopy in clinical practice in a populationwith intermediate gastric cancer risk显示文摘 | Ang TL Fock KM Teo EK | 2012 | Eur J Gastroenterol Hepatol2012，24，： | 1 |
| 8 | Psychiatric illness, personality traits and the irritable bowel syndrome显示文摘 | Fock KM Chew CN Tay LK | 2001 | Ann Acad Med Singapore2001，30，： | 1 |
| 9 | Metronidazole-resistant Helicobacter pylori in an urban Asian population 显示文摘 | Teo EK Fock KM Ng TM | 2000 | J Gastroenterol Hepatol2000，15，5： | 1 |
| 10 | Report of the Asia-Pacific consensus on the management of gastroesophageal reflux disease显示文摘 | Talley N Hunt R | 2004 | J Gastroenterol Hepatol2004，19，： | 1 |
| 11 | TheAsia-Pa- cific consensus on ulcerative colitis显示文摘 | Ooi C J Fock KM Makharia GK etal | 2010 | J Gastroenterol Hepatol2010，25，3： | 1 |
| 12 | Nocturnal acid breakthrough:Clinical significance and management显示文摘 | Fock KM | 2006 | J Gastroenterol Hepatol2006，21，5： | 1 |
| 13 | Nutritional support in acute panereatitis显示文摘 | Ong JP Fock KM | 2012 | J Dig Dis2012，13，9： | 1 |
| 14 | Asia-Pacific consensus on themanagement of gastroesophageal reflux disease: update 显示文摘 | Fock KM Talley NJ Fass R | 2008 | JGastroenterol Hepatol2008，23，1： | 1 |
| 15 | Second Asia- Pacific consensus guidelines for Helicobacter pylori infection显示文摘 | FOCK KM KATELARIS P SUGANO K et 01 | 2009 | J Gastroenterology Hepatol2009，24，10： | 1 |
| 16 | The utility of narrow bandimaging in improving the endoscopic diagnosis of gastroesophagealreflux disease 显示文摘 | Fock KM Teo EK Ang TL | 2009 | Clin Gastroenterol Hepatol2009，7，1： | 1 |
| 17 | Asia-Pacific consensus on the management of gastroesophageal reflux disease:update显示文摘 | Fock KM Talley NJ Fass R | 2008 | J Gastroenterol Hepatol2008，23，1： | 1 |
| 18 | Second Asia-Pacific Consen-sus Guidelines for Helicobacler pylori infection显示文摘 | Fock KM Katelaris P Sugano K | 2009 | J Gastroenterol Hepatol2009，24，10： | 1 |
| 19 | Gastric cacer and H·Pylori infection in Singapore: Lack of association with CagA status 显示文摘 | Ng TM Fock KM Khim MM | 1997 | Gut1997，，： | 1 |
| 20 | Asia-Pacific consensus guidelines on gastric cancer prevention显示文摘 | Fock KM Talley N Moayyedi P | 2008 | J Gastroenterol Hepa- tol2008，23，3： | 1 |
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