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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Survival outcomes of right-lobe living donor liver transplantation for patients with high Model for End-stage Liver Disease scores显示文摘BACKGROUND: Controversy exists over whether living donor liver transplantation (LDLT) should be offered to patients with high Model for End-stage Liver Disease (MELD) scores. This study tried to determine whether a high MELD score would result in inferior outcomes of right-lobe LDLT. METHODS: Among 411 consecutive patients who received right-lobe LDLT at our center, 143 were included in this study. The patients were divided into two groups according to their MELD scores: a high-score group (MELD score ≥25; n=75) and a low-score group (MELD score <25; n=68). Their demographic data and perioperative conditions were compared. Univariable and multivariable analyses were performed to identify risk factors affecting patient survival. RESULTS: In the high-score group, more patients required preoperative intensive care unit admission (49.3% vs 2.9%; P<0.001), mechanical ventilation (21.3% vs 0%; P<0.001), or hemodialysis (13.3% vs 0%; P=0.005); the waiting time before LDLT was shorter (4 vs 66 days; P<0.001); more blood was transfused during operation (7 vs 2 units; P<0.001); patients stayed longer in the intensive care unit (6 vs 3 days; P<0.001) and hospital (21 vs 15 days; P=0.015) after transplantation;more patients developed early postoperative complications (69.3% vs 50.0%; P=0.018); and values of postoperative peak blood parameters were higher. However, the two groups had comparable hospital mortality. Graft survival and patient overall survival at one year (94.7% vs 95.6%; 95.9% vs 96.9%), three years (91.9% vs 92.6%; 93.2% vs 95.3%), and five years (90.2% vs 90.2%; 93.2% vs 95.3%) were also similar between the groups. CONCLUSIONS: Although the high-score group had signifi-cantly more early postoperative complications, the two groups had comparable hospital mortality and similar satisfactory rates of graft survival and patient overall survival. Therefore, a high MELD score should not be a contraindication to right-lobe LDLT if donor risk and recipient benefit are taken into full account. | Kenneth SH Chok See Ching Chan James YY Fung Tan To Cheung Albert CY Chan Sheung Tat Fan Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 6 |
| 3 | Outcomes of right-lobe and left-lobe living-donor liver transplantations using small-for-size grafts显示文摘AIM To analyze the outcomes of living-donor liver transplantation(LDLT) using left-lobe(LL) or right-lobe(RL) small-for-size(SFS) grafts.METHODS Prospectively collected data of adult patients who underwent LDLT at our hospital in the period from January 2003 to December 2013 were reviewed. The patients were divided into the RL-LDLT group and the LL-LDLT group. The two groups were compared in terms of short-and long-term outcomes, including incidence of postoperative complication, graft function, graft survival, and patient survival. A SFS graft was defined as a graft with a ratio of graft weight(GW) to recipient standard liver volume(RSLV)(GW/RSLV) of < 50%. The Urata formula was used to estimate RSLV.RESULTS Totally 218 patients were included for analysis, with 199 patients in the RL-LDLT group and 19 patients in the LL-LDLT group. The two groups were similar in terms of age(median, 53 years in the RL-LDLT group and 52 years in the LL-LDLT group, P = 0.997) but had significantly different ratios of men to women(165:34 in the RL-LDLT group and 8:11 in the LL-LDLT group, P < 0.0001). The two groups were also significantly different in GW(P < 0.0001), GW/RSLV(P < 0.0001), and graft cold ischemic time(P = 0.007). When it comes to postoperative complication, the groups were comparable(P = 0.105). Five patients died in hospital,4(2%) in the RL-LDLT group and 1(5.3%) in the LLLDLT group(P = 0.918). There were 38 graft losses, 33(16.6%) in the RL-LDLT group and 5(26.3%) in the LL-LDLT group(P = 0.452). The 5-year graft survival rate was significantly better in the RL-LDLT group(95.2% vs 89.5%, P = 0.049). The two groups had similar 5-year patient survival rates(RL-LDLT: 86.8%, LL-LDLT: 89.5%, P = 0.476).CONCLUSION The use of SFS graft in LDLT requires careful tailormade surgical planning and meticulous operation. LLLDLT can be a good alternative to RL-LDLT with similar recipient outcomes but a lower donor risk. Further research into different patient conditions is needed in order to validate the use of LL graft. | Wong Hoi She Kenneth SH Chok James YY Fung Albert CY Chan Chung Mau Lo | 2017 | World Journal of Gastroenterology2017，23，23： | 4 |
| 4 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 5 | The correlation among obesity,apnea-hypopnea index,and tonsil size in children显示文摘 | Lam YY Chan EY Ng DK | 2006 | Chest2006，130，6： | 1 |
| 6 | Extracellularsignal-regulated kinase 1 (ERK1) and ERK2 play essentialroles in osteoblast differentiation and in supporting osteoclas-togenesis显示文摘 | Matsushita T Chan YY Kawanami A | 2009 | Mol Cell Biol2009，29，： | 1 |
| 7 | Refractory bulbar and respiratory dysfunction in a young Chinese woman with seronegative,Muscle-specific tyrosine kinase antibody-positive myasthenia gravis;response to cyclophosphamide and rituximab treatment显示文摘 | Lau AYL YY Chan AYY Mok VCT | 2011 | Hong Kong Med J2011，17，： | 1 |
| 8 | The prevalence of congenital uterine anomalies in unselected and high-risk populations : a systematic review 显示文摘 | Chan YY Jayaprakasan K Zamora J | 2011 | Hum Reprod Update2011，17，6： | 1 |
| 9 | Roles of the Racl and Rat3 GTPases in human tumor cell invasion 显示文摘 | Chan AY Coniglio SJ Chuang YY | 2005 | Oncogene2005，24，53： | 1 |
| 10 | The Correlation Among Obesity, Apnea-Hypopnea Index, and Tonsil Size in Children 显示文摘 | Lam YY Chan EY Ng DK | 2006 | Chest2006，130，6： | 1 |
| 11 | A new phytoecdysteroid from Ajuga taiwanensis显示文摘 | Chan YY Wu TS Kuoh CS | 2005 | Chem Pharm Bull2005，53，7： | 1 |
| 12 | Neoclerodane Diterpenoids from Ajuga taiwanensis显示文摘 | Chan YY | 2005 | Chem Pharm Bull2005，53，2： | 1 |
| 13 | BpeAB OprB, a multi- drug efflux pump in gurkholderia pseudomallei显示文摘 | Chan YY Tan TM Ong YM etal | 2004 | Antimi crob Agents Chemother2004，48，4： | 1 |
| 14 | Reproductive outcomes in women with congenital uterine anomalies : a systematic review 显示文摘 | Chan YY Jayaprakasan K Tan A | 2011 | Ultrasound Obstet Gynecol2011，38，4： | 1 |
| 15 | Estimating the com- plete ground reaction forces with pressure insoles in walk- ing 显示文摘 | Fong DT Chan YY Hong Y | 2008 | J Biomech2008，41，11： | 1 |
| 16 | Laparoscopic choleeystectomy for early gallbladder carcinoma: long-term outcome in comparison with conventional open cholecystectomy 显示文摘 | Chan KM Yeh TS Jan YY | 2006 | Surg Endosc2006，20，12： | 1 |
| 17 | Role of β-blockade in anesthesia and postoperative pain management after hysterectomy显示文摘 | Chia YY Chan MH Ko NH | 2004 | Br J Anesth2004，93，6： | 1 |
| 18 | Stroke risk factor,pattern and outcome in patients with cancer显示文摘 | Zhang YY Chan DK Cordato D | 2006 | Acta Neurol Scand2006，114，6： | 1 |
| 19 | The constituents of the stem and roots of Aristolochia foveolata显示文摘 | Leu YL Chan YY Hsu MY | 1998 | J Chin Chem Soc1998，45，4： | 1 |
| 20 | A single-blind, comparative study of zotepine versus haloperidol in combination with a mood sta- bilizer for patients with moderate-to-severe mania 显示文摘 | Chan HY Jou SH Juang YY | 2010 | Psychiatry Clin Neurosci2010，64，2： | 1 |
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