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| 1 | Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells显示文摘Liver fibrosis is a consequence of chronic liver disease,causing morbidity and mortality.Interleukin-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver fibrosis.Here,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in mice.We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis.Liver injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient mice.Recombinant IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK signaling.Finally,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and fibrosis.In conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis. | Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun Bernhard Ryffel | 2018 | Cellular & Molecular Immunology2018，15，4： | 24 |
| 2 | Mathematical Modeling and Effect of Various Hot-Air Drying on Mushroom(Lentinus edodes)显示文摘An experimental study was performed to determine the characteristics and drying process of mushroom(Lentinus edodes) by 6 different hot-air drying methods namely isothermal drying,uniform raise drying,non-uniform raise drying,uniform intermittent drying,non-uniform intermittent drying and combined drying.The chemical composition(dry matter,ash,crude protein,crude fat,total sugars,dietary fiber,and energy),color parameters(L,a*,b*,c*,and h0) and rehydration capacities were determined.Among all the experiments,non-uniform intermittent drying reached a better comprehensive results due to the higher chemical composition,better color quality associated with high bright(26.381±5.842),high color tone(73.670±2.975),low chroma(13.349±3.456) as well as the highest rehydration(453.76% weigh of dried body).Nine kinds of classical mathematical model were used to obtained moisture data and the Midili-kucuk model can be described by the drying process with the coefficient(R2 ranged from 0.99790 to 0.99967),chi-square(χ2 ranged from 0.00003 to 0.00019) and root mean square error(RMSE ranged from 0.000486 to 0.0012367). | GUO Xiao-hui XIA Chun-yan TAN Yu-rong CHEN Long MING Jian | 2014 | Journal of Integrative Agriculture2014，13，1： | 22 |
| 3 | Optimal allocation of multi-type FACTS devices in power systems based on power flow entropy显示文摘Flexible AC transmission systems(FACTS)devices can effectively optimize the distribution of power flow.Power flow entropy can be applied as a measure of load distribution.In this paper,a method is proposed to optimize the distribution of power flow with the coordination of multi-type FACTS devices and establishes the corresponding mathematical models.The modified group searcher optimization(GSO)algorithm is proposed,in which the angle search is combined with chaotic search model to avoid jumping into local optimization.Compared with the different optimal allocation of multi-FACTS devices,the optimal allocation of multi-FACTS devices is achieved under the economic constraints.The locations obtained by this method can achieve the purpose of balancing power flow and enhancing the system performances.The simulations are demonstrated in an IEEE 118-bus power system with two classical types of FACTS,namely static var compensator(SVC)and thyristor controlled series Compensator(TCSC).The simulation results show that the proposed method is feasible and effective. | Canbing LI Liwu XIAO Yijia CAO Qianlong ZHU Baling FANG Yi TAN Long ZENG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，2： | 23 |
| 4 | Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells显示文摘组织蛋白酶 L (CTSL ) , lysosomal 酸半胱氨酸朊酶,被知道在肿瘤起重要作用转移和化疗抵抗。在这研究,我们调查了在人的肺癌症 cells.Methods 由 CTSL 位于 chemoresistance 的规定下面的分子的机制:人的肺癌症 A549 房间, A549/PTX (paclitaxel 抵抗) 房间和 A549/DDP (cisplatin 抵抗) 房间被测试。到 cisplatin 或 paclitaxel 的抵抗用 MTT 和殖民地形成试金被检测。肌动朊改变与 FITC-Phalloidin 被观察荧光灯的染色或 immunofluorescence。愈合创伤的试金或 Transwell 试金被用来估计迁居或侵略能力。CTSL 和上皮、间充质的标记的表示与西方的弄污和 immunofluorescence 被分析。联系 EMT 的抄写因素的表示与西方的弄污或 q-PCR 被测量。BALB/c 裸体老鼠与 A549 房间 overexpressing CTSL 皮下地被植入,并且老鼠是管理 paclitaxel (10, 15 mg/kg, ip ) 为 5 times.Results 的每 3 d:Cisplatin 或 paclitaxel 治疗(10-80 ng/mL ) 在 A549 房间导致了 CTSL 表示。CTSL 层次比在 A549 房间在 A549/PTX 和 A549/DDP 房间是高得多的。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 chemoresistance,而 CTSL 的 overexpression 稀释了 A549 房间的敏感到 cisplatin 或 paclitaxel。而且, A549/DDP 和 A549/TAX 房间经历了词法并且有增加的房间侵略和迁居能力的细胞骨架变化,由上皮的标记( E-cadherin 和 cytokeratin-18 )的减少的表示伴随了并且增加间充质的标记( N-cadherin 和 vimentin )的表示,以及 联系EMT 的抄写因素的 upregulation 蜗牛,蛞蝓, ZEB1 和 ZEB2 。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 EMT;相反, CTSL 的 overexpression 在 A549 房间导致了 EMT。在异种皮移植裸体人鼠标模型,与 A549 房间 overexpressing CTSL 植入的鼠标展出了显著地减少的敏感到 paclitaxel 处理,并且在肿瘤 tissues.Conclusion 增加了联系 EMT 的蛋白质和抄写因素的表示:Cisplatin 和 paclitaxel 抵抗在 A549 房间与 CTSL 导致 upregulation 的 EMT 被联系。因此,调停 CTSL 的 EMT 可以作为一个目标被利用对肺癌症和恶意的另外的类型提高 cisplatin 或 paclitaxel 的功效。 | Mei-ling HAN Yi-fa n ZHAO Cai-hong TAN Ya-jie XIONG Wen-juan WANG Feng WU Yao FEI Long WANG Zhong-qin LIANG | 2016 | Acta Pharmacologica Sinica2016，37，12： | 15 |
| 5 | Tribological properties of laser cladding TiB_2 particles reinforced Ni-base alloy composite coatings on aluminum alloy显示文摘To improve the wear resistance of aluminum alloy frictional parts, Ti B_2 particles reinforced Ni-base alloy composite coatings were prepared on aluminum alloy 7005 by laser cladding. The microstructure and tribological properties of the composite coatings were investigated. The results show that the composite coating contains the phases of Ni Al, Ni_3Al, Al_3Ni_2, TiB_2, TiB, TiC, CrB, and Cr_(23)C_6.Its microhardness is HV_(0.5)855.8, which is 15.4 % higher than that of the Ni-base alloy coating and is 6.7 times as high as that of the aluminum alloy. The friction coefficients of the composite coatings are reduced by 6.8 %–21.6 % and 13.2 %–32.4 % compared with those of the Ni-base alloy coatings and the aluminum alloys, while the wear losses are 27.4 %–43.2 % less than those of the Ni-base alloy coatings and are only 16.5 %–32.7 % of those of the aluminum alloys at different loads. At the light loads ranging from 3 to 6 N, the calculated maximum contact stress is smaller than the elastic limit contact stress. The wear mechanism of the composite coatings is micro-cutting wear, but changes into multi-plastic deformation wear at 9 N due to the higher calculated maximum contact stress than the elastic limit contact stress. As the loads increase to 12 N, the calculated flash temperature rises to 332.1 °C.The composite coating experiences multi-plastic deformation wear, micro-brittle fracture wear, and oxidative wear. | Long He Ye-Fa Tan Xiao-Long Wang Qi-Feng Jing Xiang Hong | 2015 | Rare Metals2015，34，11： | 14 |
| 6 | PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum显示文摘在充满脯氨酸的 transmembrane 蛋白质的变化(PRRT2 ) 2 与发作性的 kinesigenic 运动障碍(PKD ) 和几另外的发作性的神经病学的疾病被联系,但是 PRRT2 功能和病原的机制仍然保持大部分阴暗。这里,我们证明 PRRT2 是与 SNARE 建筑群和 downregulates 的部件交往的 presynaptic 蛋白质它的形成。Loss-of-function 变异的老鼠显示出显型由小脑的概括发作,过高热,或 optogenetic 刺激触发了的象 PKD 一样。有在小脑的小粒房间(GC ) 的特定的 PRRT2 删除的变异的老鼠概括在 Prrt2 空的老鼠看见的行为的显型。而且,记录在显示出的小脑的片做了在短暂举起的 GC 结果的刺激由 Purkinje 房间开火的抑制跟随了的那 optogenetic。在 PKD 处理使用的 anticonvulsant 药 carbamazepine 也在变异的老鼠减轻了象 PKD 一样行为。一起,我们的调查结果作为 SNARE 建筑群的一个新奇管理者识别 PRRT2 并且提供位于 PRRT2 相关的行为下面的电路机制。 | Guo-He Tan Yuan-Yuan Liu Lu Wang Kui Li Ze-Qiang Zhang Hong-Fu Li Zhong-Fei Yang Yang Li Dan Li Ming-Yue Wu Chun-Lei Yu Juan-Juan Long Ren-Chao Chen Li-Xi Li Lu-Ping Yin Ji-Wei Liu Xue-Wen Cheng Qi Shen You-Sheng Shu Kenji Sakimura Lu-Jian Liao Zhi-Ying Wu Zhi-Qi Xiong | 2018 | Cell Research2018，28，1： | 14 |
| 7 | The effect of immediate surgical bipolar plasmakinetic transurethral resection of the prostate on prostatic hyperplasia with acute urinary retention显示文摘在现在的学习,我们评估了立即的外科的双极的 plasmakinetic 的安全和功效为有有尖锐尿保留(AUR ) 的良性的 prostatic 增生(BPH ) 的病人的前列腺(PK-TURP ) 的经尿道的切除术。我们进行了收到了 PK-TURP 的 BPH 病人的临床的数据的回顾的分析。1126 个 BPH 病人的一个总数被划分成 AUR (n = 348 ) 并且 non-AUR 组(n = 778 ) 。在尿道的导管被移开以后,在 AUR 组的尿白人血房间(白血球) 计数显著地与 non-AUR 组相比增加了(P < 0.01 ) 。然而,在国际前列腺症状分数,痛苦的泌尿,和最大的尿流动率没有重要差别。AUR 组的住院的持续时间比 non-AUR 组的长(P < 0.001 ) 。在 AUR 的病人组织的 87.1% 的一个总数(303/348 ) 并且 84.1%(654/778 ) 在 non-AUR 组的病人手术后的后续访问完成了所有。在在在外科以后的 3 个月以内的 AUR 组的尿道感染的发生在 non-AUR 组比那显著地高(P < 0.01 ) 。在 AUR 组的暂时的尿不能自制的发生没展出重要差别。在在外科以后的 3-12 月期间,在在二个组之间的主要复杂并发症没有重要差别。Multivariate 回归分析出现了那年龄, postvoid 剩余,最大的尿流动率,糖尿病,和高血压,然而并非 AUR 的存在,是 IPSS post-PK-TURP 的独立预言者。在结论, AUR 伴随的病人上的立即的 PK-TURP 外科安全、有效。 | Le-Ye He Yi-Chuan Zhang Jing-Liang He Liu-Xun Li Yong Wang Jin Tang Jing Tan Kuangbaio Zhong Yu-Xin Tang Zhi Long | 2016 | Asian Journal of Andrology2016，18，1： | 12 |
| 8 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 9 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 10 | RhB Adsorption Performance of Magnetic Adsorbent Fe_3O_4/RGO Composite and Its Regeneration through A Fenton-like Reaction显示文摘Adsorption is one of the most effective technologies in the treatment of colored matter containing wastewater. Graphene related composites display potential to be an effective adsorbent. However, the adsorption mechanism and their regeneration approach are still demanding more efforts. An effective magnetically separable absorbent, Fe3O4 and reduced graphene oxide(RGO) composite has been prepared by an in situ coprecipitation and reduction method. According to the characterizations of TEM, XRD, XPS, Raman spectra and BET analyses, Fe3O4 nanoparticles in sizes of 10-20 nm are well dispersed over the RGO nanosheets, resulting in a highest specific area of 296.2 m2/g. The rhodamine B adsorption mechanism on the composites was investigated by the adsorption kinetics and isotherms. The isotherms are fitting better by Langmuir model, and the adsorption kinetic rates depend much on the chemical components of RGO. Compared to active carbon, the composite shows 3.7 times higher adsorption capacity and thirty times faster adsorption rates. Furthermore,with Fe3O4 nanoparticles as the in situ catalysts, the adsorption performance of composites can be restored by carrying out a Fenton-like reaction, which could be a promising regeneration way for the adsorbents in the organic pollutant removal of wastewater. | Yalin Qin Mingce Long Beihui Tan Baoxue Zhou | 2014 | Nano-Micro Letters2014，6，2： | 11 |
| 11 | Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Th1/Th2 Cytokines显示文摘Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the | TAN Long SANG Zhong Na SHEN Jun WU Yun Tang YAO Zhai Xiao ZHANG Jin Xiang ZHAO Na ZHANG Wan Qi | 2013 | Biomedical and Environmental Sciences2013，26，11： | 10 |
| 12 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 13 | Sulfur speciation and bioaccumulation in camphor tree leaves as atmospheric sulfur indicator analyzed by synchrotron radiation XRF and XANES显示文摘Analyzing and understanding the effects of ambient pollution on plants is getting more and more attention as a topic of environmental biology.A method based on synchrotron radiation X-ray fluorescence and X-ray absorption near edge structure spectroscopy was established to analyze the sulfur concentration and speciation in mature camphor tree leaves (CTLs),which were sampled from 5 local fields in Shanghai,China.Annual SO2 concentration,SO42-concentration in atmospheric particulate,SO42-and sulfur concentration in soil were also analyzed to explore the relationship between ambient sulfur sources and the sulfur nutrient cycling in CTLs.Total sulfur concentration in mature camphor tree leaves was 766-1704 mg/kg.The mainly detected sulfur states and their corresponding compounds were +6 (sulfate,include inorganic sulfate and organic sulfate),+5.2 (sulfonate),+2.2 (suloxides),+0.6 (thiols and thiothers),+0.2 (organic sulfides).Total sulfur concentration was strongly correlated with sulfate proportion with a linear correlation coefficient up to 0.977,which suggested that sulfur accumulated in CTLs as sulfate form.Reduced sulfur compounds (organic sulfides,thiols,thioethers,sulfoxide and sulfonate) assimilation was sufficed to meet the nutrient requirement for growth at a balanced level around 526 mg/kg.The sulfate accumulation mainly caused by atmospheric sulfur pollution such as SO2 and airborne sulfate particulate instead of soil contamination.From urban to suburb place,sulfate in mature CTLs decreased as the atmospheric sulfur pollution reduced,but a dramatic increase presented near the seashore,where the marine sulfate emission and maritime activity pollution were significant.The sulfur concentration and speciation in mature CTLs effectively represented the long-term biological accumulation of atmospheric sulfur pollution in local environment. | Jianrong Zeng Guilin Zhang Liangman Bao Shilei Long Mingguang Tan Yan Li Chenyan Ma Yidong Zhao | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 14 | Spatio-temporal changes in rice area at the northern limits of the rice cropping system in China from 1984 to 2013显示文摘Rice area has been expanding rapidly during the past 30 years under the influence of global change in northeastern China,which is the northernmost region of rice cultivation in China. However,the spatio-temporal dynamic changes in rice area are still unclear,although they may have important policy implications for environmental protection and adaptation to climate change. In this study,we aimed to identify the dynamic changes of the rice area in Heilongjiang Province of northeastern China by extracting data from multiple Landsat images. The study used ground quadrats selected from Google Earth and the extraction of a confusion matrix to verify the accuracy of extraction. The overall accuracy of the extracted rice area was higher than 95% as a result of using the artificial neural network(ANN) classification method. The results showed that the rice area increased by approximately 2.4×106 ha during the past 30 years at an annual rate of 8.0×104 ha,and most of the increase occurred after 2000. The central latitude of the rice area shifted northwards from 46 to 47°N during the study period,and moved eastwards from 130 to 133°E. The rice expansion area accounted for 98% of the total change in rice area,and rice loss was notably rare. The rice expansion was primarily from dryland. In addition,rice cultivation in marshland and grassland played a minor role in the rice expansion in this region. | LI Zhi-peng LONG Yu-qiao TANG Peng-qin TAN Jie-yang LI Zheng-guo WU Wen-bin HU Ya-nan YANG Peng | 2017 | Journal of Integrative Agriculture2017，16，2： | 9 |
| 15 | Coral reef-like polyanaline nanotubes prepared by a reactive template of manganese oxide for supercapacitor electrode显示文摘由 nanopaticles 组成的珊瑚像礁石的 PANI nanotubes 被锰氧化物的一个反应模板成功地综合。结构被使用 SEM, TEM,和英尺红外描绘,并且这些 nanotubes 的 supercapacitive 行为与周期的 voltammetry (CV ) 被调查,并且 chargedischarge 分别地测试。533 F/g 的一个最大的特定的电容能在 1 mol/L 被完成有 0.2 ~ 0.8 V 的潜在的范围的水的 H2SO4 (对浸透的甘汞电极) 在为 PANI 电极的一种一半房间安装配置,为电气化学的电容器在电极材料建议它的潜在的申请。 | Ling Ren Wang Fen Ran Yong Tao Tan Lei Zhao Ling Bin Kong Long Kang | 2011 | Chinese Chemical Letters2011，22，8： | 8 |
| 16 | Influence of weight management on the prognosis of steatohepatitis in chronic hepatitis B patients during antiviral treatment显示文摘Background:Although concomitant nonalcoholic steatohepatitis(NASH)is common in chronic hepatitis B(CHB),the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear.We aimed to investigate the outcomes of NASH in CHB patients receiving antiviral treatment.Methods:In the post-hoc analysis of a multicenter trial,na?ve CHB patients receiving 72-week entecavir treatment were enrolled.We evaluated the biochemical,viral and histopathological responses of these patients.The histopathological features of NASH were also evaluated,using paired liver biopsies at baseline and week 72.Results:A total of 1000 CHB patients were finally enrolled for analysis,with 18.2%of whom fulfilling the criteria of NASH.A total of 727 patients completed entecavir antiviral treatment and received the second biopsy.Serum HBe Ag loss,HBe Ag seroconversion and HBV-DNA undetectable rates were similar between patients with or without NASH(P>0.05).Among patients with NASH,the hepatic steatosis,ballooning,lobular inflammation scores and fibrosis stages all improved during follow-up(all P<0.001),46%(63/136)achieved NASH resolution.Patients with baseline body mass index(BMI)≥23 kg/m2(Asian criteria)[odds ratio(OR):0.414;95%confidence interval(95%CI):0.190-0.899;P=0.012]and weight gain(OR:0.187;95%CI:0.050-0.693;P=0.026)were less likely to have NASH resolution.Among patients without NASH at baseline,22(3.7%)developed NASH.Baseline BMI≥23 kg/m2(OR:12.506;95%CI:2.813-55.606;P=0.001)and weight gain(OR:5.126;95%CI:1.674-15.694;P=0.005)were predictors of incident NASH.Conclusions:Lower BMI and weight reduction but not virologic factors determine NASH resolution in CHB.The value of weight management in CHB patients during antiviral treatment deserves further evaluation. | Xiu-Juan Chang Yi-Wen Shi Jing Wang Hua-Bao Liu Yan Chen Xiao-Ning Zhu Yong-Ping Chen Zu-Jiang Yu Qing-Hua Shang Lin Tan Qin Li Li Jiang Guang-Ming Xiao Liang Chen Wei Lu Xiao-Yu Hu Qing-Hua Long Lin-Jing An Zi-Yuan Zou Vincent Wai-Sun Wong Yong-Ping Yang Jian-Gao Fan | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，5： | 8 |
| 17 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 18 | Ultrasensitive and stable X-ray detection using zero-dimensional lead-free perovskites显示文摘Sensitive and reliable X-ray detectors are essential for medical radiography,industrial inspection and security screening.Lowering the radiation dose allows reduced health risks and increased frequency and fidelity of diagnostic technologies for earlier detection of disease and its recurrence.Three-dimensional(3 D)organic-inorganic hybrid lead halide perovskites are promising for direct X-ray detection-they show improved sensitivity compared to conventional X-ray detectors.However,their high and unstable dark current,caused by ion migration and high dark carrier concentration in the 3 D hybrid perovskites,limits their performance and long-term operation stability.Here we report ultrasensitive,stable X-ray detectors made using zero-dimensional(0 D)methylammonium bismuth iodide perovskite(MA3Bi2I9)single crystals.The 0 D crystal structure leads to a high activation energy(Ea)for ion migration(0.46 e V)and is also accompanied by a low dark carrier concentration(~10^6 cm^-3).The X-ray detectors exhibit sensitivity of 10,620μC Gy-1 air cm-2,a limit of detection(Lo D)of 0.62 nG yairs-1,and stable operation even under high applied biases;no deterioration in detection performance was observed following sensing of an integrated X-ray irradiation dose of^23,800 m Gyair,equivalent to>200,000 times the dose required for a single commercial X-ray chest radiograph.Regulating the ion migration channels and decreasing the dark carrier concentration in perovskites provide routes for stable and ultrasensitive X-ray detectors. | Xiaojia Zheng Wei Zhao Peng Wang Hairen Tan Makhsud I.Saidaminov Shujie Tie Ligao Chen Yufei Peng Jidong Long Wen-HuZhang | 2020 | Journal of Energy Chemistry2020，29，10： | 7 |
| 19 | Preparation and Characterization of Microencapsulated Hexadecane Used for Thermal Energy Storage显示文摘Polyurea microcapsules about 2.5μm in diameter containing phase change material for thermal energy storage application were synthesized and characterized by interfacial polycondensation method with toluene-2,4-diisocyanate and ethylenediamine as monomers in an emulsion system. Hexadecane was used as a phase change material and OP, which is nonionic surfactant, and used as an emulsifier. The chemical structure and thermal behavior of the microcapsules were investigated by FTIR and thermal analysis respectively. The results show encapsulated hexadecane has a good potential as a solar energy storage material. | Guang Long ZOU Zhi Cheng TAN Xiao Zheng LAN Li Xian SUN Tao ZHANG | 2004 | Chinese Chemical Letters2004，15，6： | 7 |
| 20 | Bare sclera resection followed by mitomycin C and/or autograft limbus conjunctiva in the surgery for pterygium:a Meta-analysis显示文摘AIM: To evaluate the recurrence and complications after bare sclera resection(BSR) combined with mitomycin C(MMC) treatment and/or autograft limbus conjunctiva(ALC) in the surgery for pterygium.·METHODS: Meta-analysis was used to evaluate the differences in patient outcomes between BSR of pterygium with or without MMC and/or ALC. All included studies were randomized trials of patients with pterygium who received BSR followed by MMC and/or ALC in the surgery. The recurrence of pterygium and other complications resulting from different treatments were extracted for analysis.·RESULTS: Thirteen studies met the inclusion criteria.The recurrence of pterygium with intraoperative(IO) MMC was higher than that with ALC(OR=2.38,95% confidence interval 1.45-3.91, I2=29%). Postoperative MMC resulted in an incidence of recurrence similar to that of ALC(OR=0.66, 95% confidence interval 0.30-1.42, I2=0%), and IO MMC treatment in combination with ALC produced similar patient outcomes to ALC alone(OR =0.41, 95%confidence interval 0.16-1.01, I2=16%). Other complications such as punctate epitheliopathy, scleral thinning and ischemia, irritation and persistent epithelium defect, were more common in patients in the MMC group as compared to those treated with ALC.·CONCLUSION: The recurrence of pterygium with BSR followed by ALC is lower than that of BSR followed by MMC, and the incidence of other complications is lower.While ALC is a more effective strategy for treating pterygium, the quality of the ALC transplant should be considered when the patient has a history of glaucoma. | Tan Long Zhi Li | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 7 |
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