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| 1 | 腐殖酸与盐分浓度对石灰加固土有明黏土的影响以及微观结构研究显示文摘首先从力学性质方面考察了有机质之一的腐殖酸和盐分浓度对于石灰加固土的影响。分析的结果显示对于腐殖酸含量较高的黏土由于凝硬反应被阻碍使得加固土的强度与屈服应力较小,并且由于盐分浓度较高时腐殖酸活性降低,因此随着盐分浓度的增加腐殖酸对于石灰加固土的影响减小。然后通过分析加固土的微观结构,我们讨论了石灰加固土的力学性质与微观结构之间的关联性。 | Chirdchanin MODMOLTIN 陆江 Katsutada ONITSUKA | 2004 | 岩土工程学报2004，26，2： | 11 |
| 2 | Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel显示文摘AIM To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto(DKT) associated with transient receptor potential ankyrin 1(TRPA1) channels in intestinal myofibroblasts. METHODS Inflammatory and fibrotic changes were detected in a2,4,6-trinitrobenzenesulfonic acid(TNBS) chronic colitis model of wild-type and TRPA1-knockout(TRPA1-KO) mice via pathological staining and immunoblotting analysis.Ca^(2+) imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast(In Myo Fib) cell TRPA1 channel function.Profibrotic factors and transforming growth factor (TGF) -β1-associated signaling were tested in an In Myo Fib cell line by q PCR and immunoblotting experiments.Samples from non-stenotic and stenotic regions of the intestines of patients with Crohn’s disease (CD) were used for pathological analysis. RESULTS Chronic treatment with TNBS caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice.A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO mice.The active ingredients of DKT,i.e.,hydroxyα-sanshool and 6-shogaol,induced Ca^(2+) influxes in In Myo Fib,and this was antagonized by co-treatment with a selective TRPA1 channel blocker,HC-030031.DKT counteracted TGF-β1-induced expression of TypeⅠcollagen andα-smooth muscle actin (α-SMA) ,which were accompanied by a reduction in the phosphorylation of Smad-2 and p38-mitogen-activated protein kinase (p38-MAPK) and the expression of myocardin.Importantly,24-h incubation with a DKT active component Japanese Pepper increased the m RNA and protein expression levels of TRPA1 in In Myo Fibs,which in turn negatively regulated collagen synthesis.In the stenotic regions of the intestines of CD patients,TRPA1 expression was significantly enhanced.CONCLUSION The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis,and benefit inflammatory bowel disease treatment. | Keizo Hiraishi Lin-Hai Kurahara Miho Sumiyoshi Yao-Peng Hu Kaori Koga Miki Onitsuka Daibo Kojima Lixia Yue Hidetoshi Takedatsu Yu-Wen Jian Ryuji Inoue | 2018 | World Journal of Gastroenterology2018，24，35： | 2 |
| 3 | Purification and characterization of pepriplasmic a-amylase from Xanthomonas campestris K-11151显示文摘 | Jun-ICHI ABE Naoki Onitsuka Takashi Nakano | 1994 | J Bacteriol1994，176，12： | 1 |
| 4 | New polysilicic acid coagulants and their properties显示文摘 | Takao Hasegawa Takuya Onitsuka | 1989 | Water Research1989，，5： | 1 |
| 5 | Consolidation of ground with partially penetrated vertical drains显示文摘 | Tang Xiaowu Onitsuka K | 1998 | Geotechnical Engineer Journal1998，29，2： | 1 |
| 6 | Characteristics of metal-polysilicate coagulants显示文摘 | HASEGAWA T HASHIMOTO K ONITSUKA T | 1991 | Wat Sci Tech1991，，23： | 1 |
| 7 | Dewatering characteristics of dredged sediment with polysilicate-iron(Ⅲ) coagulants显示文摘 | Shoichiro Y Hasegawa T Onitsuka T | 1991 | Industrial Water1991，399，： | 1 |
| 8 | Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsyehology in schizophrenia显示文摘 | Nestor PG Onitsuka T Gurrera RJ | 2007 | Schizophr Res2007，91，13： | 1 |
| 9 | A method of correcting yield stress and compression index of Ariake clays for sample disturbance显示文摘 | Onitsuka K | 1998 | Soils and Foundations1998，38，2： | 1 |
| 10 | Effects of sediments on larval settlement of abalone Haliotis diversicolor 显示文摘 | ONITSUKA T KAWAMURA T OHASHI S | 2008 | Journal of Experimental Marine Biology and Ecology2008，365，1： | 1 |
| 11 | Consolidation of Ground with Partially Penetrated Vertical Drains显示文摘 | Tang X W Onitsuka K | 1998 | Geotechnical Engineering Journal1998，29，2： | 1 |
| 12 | Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons显示文摘 | Onitsuka M Mihara S Yamamoto S | | 0，，： | 1 |
| 13 | Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status显示文摘 | Takamitsu Onitsuka Hidetaka Uramoto Naohiro Nose Mitsuhiro Takenoyama Takeshi Hanagiri Kenji Sugio Kosei Yasumoto | 2009 | Lung Cancer2009，，2： | 1 |
| 14 | Influence of Age on Extend Thymectomyas a Theatment for Myasthenia Gravis显示文摘 | Matsuzaki Y Tomita M Onitsuka T | 1998 | Ann Thorac Cardio Surg1998，4，4： | 1 |
| 15 | Dewatering characteristics of dredged sediment with polysilieate-iren (Ⅲ)coagulants 显示文摘 | Shoiehiro Y Hasegawa T Onitsuka T | 1991 | Industrial Water1991，399，： | 1 |
| 16 | Cell engineering and cultivation of Chinese hamster ovary ( CHO ) cells 显示文摘 | Omasa T Onitsuka M Kim W D | 2010 | Curr Pharmac Biotech2010，11，3： | 1 |
| 17 | Multiple dural arteriovenous fistulae involving the cavernous and sphenoparietal sinuses显示文摘 | T. Watanabe Y. Matsumaru M. Sonobe T. Asahi K. Onitsuka K. Sugita S. Takahashi T. Nose | 2000 | Neuroradiology2000，，10： | 1 |
| 18 | Electroluminescence from CdSe quantum-dot/polymer composites 显示文摘 | Dabbousi B O Bawendi M G Onitsuka O | 1995 | Appl Phys Lett1995，66，： | 1 |
| 19 | Twist promotes tumor cellgrowth through YB-1 expression 显示文摘 | Shiota M Izumi H Onitsuka T | 2008 | Cancer Res2008，68，1： | 1 |
| 20 | Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status显示文摘 | Takamitsu Onitsuka Hidetaka Uramoto Naohiro Nose Mitsuhiro Takenoyama Takeshi Hanagiri Kenji Sugio Kosei Yasumoto | 2009 | Lung Cancer2009，，2： | 1 |
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