|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Depletion of CD25^+CD4^+T cells (Tregs) enhances the HBV-specific CD8^+ T cell response primed by DNA immunization显示文摘AIM: Persistent hepatitis B virus (HBV) infection is characterized by a weak CD8+ T cell response to HBV. Immunotherapeutic strategies that overcome tolerance and boost these suboptimal responses may facilitate viral clearance in chronically infected individuals. Therefore, we examined whether CD25+CD4+ regulatory T (Treg) cells might be involved in a inhibition of CD8+T cell priming or in the modulation of the magnitude of the'peak' antiviral CD8+ T cell response primed by DNA immunization. METHODS: B10.D2 mice were immunized once with plasmid pCMV-S. Mice received 500 μg of anti-CD25 mAb injected intraperitoneally 3 d before DNA immunization to deplete CD25+ cells. Induction of HBV-specific CD8+ T ceils in peripheral blood mononuclear cells (PBMCs) was measured by S28-39 peptide loaded DimerX staining and their function was analyzed by intracellular IFN-γ staining.RESULTS: DNA immunization induced HBV-specific CD8+ T cells. At the peak T cell response (d 10), 7.1±2.0% of CD8+ T cells were HBV-specific after DNA immunization, whereas 12.7±3.2% of CD8+ T cells were HBV-specific in Treg-depleted mice, suggesting that DNA immunization induced more antigen-specific CD8+ T cells in the absence of CD25+ Treg cells (n = 6, P<0.05). Similarly, fewer HBVspecific memory T cells were detected in the presence of these cells (1.3±0.4%) in comparison to Treg-depleted mice (2.6±0.9%) on d 30 after DNA immunization (n = 6, P<0.01). Both IFN-γ production and the avidity of the HBV-specific CD8+ T cell response to antigen were higher in HBV-specific CD8+ T cells induced in the absence of Treg cells.CONCLUSION: CD25+ Treg cells suppress priming and/or expansion of antigen-specific CD8+ T cells during DNA immunization and the peak CD8+ T cell response is enhanced by depleting this cell population. Furthermore, Treg cells appear to be involved in the contraction phase of the CD8+ T ceil response and may affect the quality of memory T cell pools. The elimination of Treg cells or their inhibition may be important in immunotherapeutic strategies to control HBV infection by inducing virus-specific cytotoxic T lymphocyte responses in chronically infected subjects. | Yoshihiro Furuichi Hirotake Tokuyama Satoshi Ueha Makoto Kurachi Fuminori Moriyasu Kazuhiro Kakimi | 2005 | World Journal of Gastroenterology2005，11，24： | 30 |
| 2 | Cause and Management of Recurrent Primary Spontaneous Pneumothorax After Thoracoscopic Stapler Blebectomy显示文摘 | Takashi Muramatsu Mie Shimamura Motohiko Furuichi Tatsuhiko Nishii Shinji Takeshita Shinichiro Ishimoto Hiroaki Morooka Yoko Tanaka Chiyoshi Yagasaki Kazumitsu Ohmori Motomi Shiono | 2011 | Asian Journal of Surgery2011，，2： | 2 |
| 3 | Quasi-stationary flow structure in turbidity currents显示文摘A turbidity current is a particle-laden current driven by density differences due to suspended sediment particles.Turbidity currents can transport large amounts of sediment down slopes over great distances,and play a significant role in fluvial,lake and submarine systems.To better understand the sediment transport process,the flow system of an experimentally produced turbidity current in an inclined flume was investigated using video processing.We observed that the current progresses with constant frontal velocity and maintains an unchanged global interface geometry.In addition,the spatio-temporal profiles of the inner mean and turbulence velocity obtained by ultrasound velocity profiler(UVP)showed that similar distributions were maintained,with low dissipation.The results indicate that the turbidity current progressed in a quasi-stationary state,which enabled long-distance sediment transport.To understand the mechanisms behind the quasi-stationary flow,we analyzed the forces acting on the turbidity current.We found that under particular densities of suspended particles,the gravitational force is balanced by the viscous forces along the slope direction.We conclude that this specific force balance induces the quasi-stationary flow structure,enabling the long-distance transport of a substantial amount of sediment downstream with low dissipation. | Shun Nomura Giovanni De Cesare Mikito Furuichi Yasushi Takeda Hide Sakaguchi | 2020 | International Journal of Sediment Research2020，35，6： | 2 |
| 4 | Chemokine/chemokine receptor-mediated inflammation regulates pathologicchanges from acute kidney injury to chronic kidney dis- ease显示文摘 | Furuichi K Kaneko S Wada T | 2009 | Clin Exp Nephrol2009，13，1： | 1 |
| 5 | Identification of tranilast-binding protein as 36-kDa microfibril-associated glycoprotein by drug affinity chromatography, and its localization in human skin显示文摘 | FURUICHI H YAMASHITA K OKADA M | 2000 | Biochem Biophys Res Commun2000，270，3： | 1 |
| 6 | Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor(MCAF/MCP- 1) 显示文摘 | Wada T Yokoyama H Furuichi K | 1996 | FASEB J1996，10，12： | 1 |
| 7 | Overexpression of Cbfal in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures显示文摘 | Liu W Toyosawa S Furuichi T | 2001 | J Cell Biol2001，155，1： | 1 |
| 8 | Mel Log Spectrum Approximation (MLSA) Filter for Speech Synthesis显示文摘 | IMAI S SUMITA K FURUICHI C | 1983 | Electronics and Communications in Japan1983，66，02： | 1 |
| 9 | Drivers' behavior in S curve negotiations on an urban motorway显示文摘 | Furuichi T Iwasaki M Kadoma T | 2002 | Traffic Transport Stud2002，，2： | 1 |
| 10 | B-type natriuretic peptides strongly reflects diastolic wall stress in patients with chronic heart failure:comparison between systolic and diastolic heart failure显示文摘 | Iwanaga Y Nishi I Furuichi S | | 0，，04： | 1 |
| 11 | The role of cytokine in the lupus nephritis显示文摘 | IWATA Y FURUICHI K KANEKO S | 2011 | Bio Med Research International2011，2011，： | 1 |
| 12 | Schr?dinger uncertainty relation,Wigner-Yanase-Dyson skew information and metric adjusted correlation measure显示文摘 | Furuichi S Yanagi K | 2012 | Journal of Mathematical Analysis and Applications2012，388，2： | 1 |
| 13 | Urinary levels of chemokines reflect distinct disease activities and phases of human IgA nephropathy显示文摘 | YOKOYAMA H WADA T FURUICHI K | 1998 | J Leukocyte Biol1998，63，： | 1 |
| 14 | Bending fatigue properties of a superelastic thin tube and a high-elastic thin wire of TiNi alloy显示文摘 | Tobushi H Furuichi F Sakurag T | 2009 | Materials Transactions2009，50，8： | 1 |
| 15 | B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: comparison between systolic and diastolic heart failure 显示文摘 | Iwanaga Y Nishi I Furuichi S | 2006 | J Am Coll Cardiol2006，47，4： | 1 |
| 16 | Blockade of VEGF accelerates proteinuria,via decrease in nephrin expression in rat crescentic glomer- ulonephritis 显示文摘 | Hara A Wada T Furuichi K | 2006 | Kidney Int2006，69，11： | 1 |
| 17 | Neuroprotective action of tacrolimus (FKS06) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy 显示文摘 | Furuichi Y Katsuta K Maeda M | 2003 | Brain Res2003，965，： | 1 |
| 18 | up2regulation ofmonocyte chemoattractant Protein in tubulointerstitial lesions of human diabetic nephropathy显示文摘 | Furuichi K SakaiN | 2000 | kidney Int2000，58，： | 1 |
| 19 | B- type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: comparison between systolic and diastolic heart failure显示文摘 | IWANAGA Y NISHI I FURUICHI S | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 20 | Change of blood sugar and plasma insulin levels of fishes in glucose tolerance test显示文摘 | Furuichi M Yone Y | 1981 | Bull Jpn Soc Sci Fish1981，47，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员