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| 1 | Stem cell-based regenerative opportunities for the liver: State of the art and beyond显示文摘The existing mismatch between the great demand for liver transplants and the number of available donor organs highlights the urgent need for alternative therapeutic strategies in patients with acute or chronic liver failure. The rapidly growing knowledge on stem cell biology and the intrinsic repair processes of the liver has opened new avenues for using stem cells as a cell therapy platform in regenerative medicine for hepatic diseases. An impressive number of cell types have been investigated as sources of liver regeneration: adult and fetal liver hepatocytes,intrahepatic stem cell populations,annex stem cells,adult bone marrow-derived hematopoietic stem cells,endothelial progenitor cells,mesenchymal stromal cells,embryonic stem cells,and induced pluripotent stem cells. All these highly different cell types,used either as cell suspensions or,in combination with biomaterials as implantable liver tissue constructs,have generated great promise for liver regeneration. However,fundamental questions still need to be addressed and critical hurdles to be overcome before liver cell therapy emerges. In this review,we summarize the state-of-the-art in the field of stem cell-based therapies for the liver along with existing challenges and future perspectives towards a successful liver cell therapy that will ultimately deliver its demanding goals. | Eleftheria Tsolaki Evangelia Yannaki | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 3 | Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis显示文摘BACKGROUND To date, the histopathological parameters predicting the risk of lymph node (LN) metastases and local recurrence, associated mortality and appropriateness of endoscopic or surgical resection in patients with gastric neuroendocrine neoplasms type 1 (GNENs1) have not been fully elucidated. AIM To determine the rate of LN metastases and its impact in survival in patients with GNEN1 in relation to certain clinico-pathological parameters. METHODS The PubMed, EMBASE, Cochrane Library, Web of Science and Scopus databases were searched through January 2019. The quality of the included studies and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS) in accordance with the Cochrane guidelines. A random effects model and pooled odds ratios (OR) with 95%CI were applied for the quantitative meta-analysis. RESULTS We screened 2933 articles. Thirteen studies with 769 unique patients with GNEN1 were included. Overall, the rate of metastasis to locoregional LNs was 3.3%(25/769). The rate of LN metastases with a cut-off size of 10 mm was 15.3% for lesions > 10 mm (vs 0.8% for lesions < 10 mm) with a random-effects OR of 10.5 (95%CI: 1.4 -80.8;heterogeneity: P = 0.126;I2 = 47.5%). Invasion of the muscularis propria was identified as a predictor for LN metastases (OR: 17.2;95%CI: 1.8-161.1;heterogeneity: P = 0.165;I2 = 44.5%), whereas grade was not clearly associated with LN metastases (OR: 2;95%CI: 0.3-11.6;heterogeneity: P = 0.304;I2 = 17.4%). With regard to GNEN1 local recurrence, scarce data were available. The 5-year disease-specific survival for patients with and without LN metastases was 100% in most available studies irrespective of the type of intervention. Surgical resection was linked to a lower risk of recurrence (OR: 0.3;95%CI: 0.1-1.1;heterogeneity: P = 0.173;I2 = 31.9%). The reported complication rates of endoscopic and surgical intervention were 0.6 and 3.8%, respectively. CONCLUSION This meta-analysis confirms that tumor size ≥ 10 mm and invasion of the muscularis propria are linked to a higher risk of LN metastases in patients with GNEN1. Overall, the metastatic propensity of GNEN1 is low with favorable 5- year disease-specific survival rates reported;hence, no clear evidence of the prognostic value of LN positivity is available. Additionally, there is a lack of evidence supporting the prediction of local recurrence in GNEN1, even if surgery was more often a definitive treatment. | Apostolos V Tsolakis Athanasia Ragkousi Miroslav Vujasinovic Gregory Kaltsas Kosmas Daskalakis | 2019 | World Journal of Gastroenterology2019，25，35： | 6 |
| 4 | A case of primary isolated non-Hodgkin’s lymphoma of the esophagus in an immunocompetent patient显示文摘Primary non-Hodgkin’s lymphoma of the esophagus is a rare disease.A case of primary isolated nonHodgkin’s lymphoma of the esophagus in a 77-yearold man without acquired immunodeficiency syndrome is presented.We describe the clinical features and the imaging findings(barium swallow,endoscopic ultrasonography and CT)of a biopsy proven B-cell lymphoma with diffuse transmural involvement of the esophagus wall,which was discovered incidentally.We also briefly review the literature. | Ioannis V Kalogeropoulos Athanasios N Chalazonitis Sofia Tsolaki Fotios Laspas Nikolaos Ptohis Ioannis Neofytou Dimitra Rontogianni | 2009 | World Journal of Gastroenterology2009，15，15： | 5 |
| 5 | Clinical decision support systems for brain tumor characterization using advanced magnetic resonance imaging techniques显示文摘In recent years, advanced magnetic resonance imaging(MRI) techniques, such as magnetic resonance spec-troscopy, diffusion weighted imaging, diffusion tensor imaging and perfusion weighted imaging have been used in order to resolve demanding diagnostic prob-lems such as brain tumor characterization and grading, as these techniques offer a more detailed and non-invasive evaluation of the area under study. In the last decade a great effort has been made to import and utilize intelligent systems in the so-called clinical deci-sion support systems(CDSS) for automatic processing, classification, evaluation and representation of MRI data in order for advanced MRI techniques to become a part of the clinical routine, since the amount of data from the aforementioned techniques has gradually inticle is two-fold. The first is to review and evaluate the progress that has been made towards the utilization of CDSS based on data from advanced MRI techniques. The second is to analyze and propose the future work that has to be done, based on the existing problems and challenges, especially taking into account the new imaging techniques and parameters that can be intro-duced into intelligent systems to significantly improve their diagnostic specificity and clinical application. | Evangelia Tsolaki Evanthia Kousi Patricia Svolos Efthychia Kapsalaki Kyriaki Theodorou Constastine Kappas Ioannis Tsougos | 2014 | World Journal of Radiology2014，6，4： | 2 |
| 6 | Infrapopliteal Application of Sirolimus-eluting versus Bare Metal Stents for Critical Limb Ischemia: Analysis of Long-term Angiographic and Clinical Outcome显示文摘 | Dimitris Siablis Dimitris Karnabatidis Konstantinos Katsanos Athanasios Diamantopoulos Stavros Spiliopoulos George C. Kagadis John Tsolakis | 2009 | Journal of Vascular and Interventional Radiology2009，，： | 2 |
| 7 | Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease显示文摘 | Jannis Kountouras Marina Boziki Emmanuel Gavalas Christos Zavos Nikolaos Grigoriadis Georgia Deretzi Dimitrios Tzilves Panagiotis Katsinelos Magda Tsolaki Dimitrios Chatzopoulos Ioannis Venizelos | 2009 | Journal of Neurology2009，，5： | 2 |
| 8 | Chronic pancreatitis and the heart disease:Still terra incognita?显示文摘BACKGROUND It has been suggested that chronic pancreatitis(CP)may be an independent risk factor for development of cardiovascular disease(CVD).At the same time,it seems that congestive heart failure(CHF)and CP share the responsibility for the development of important clinical conditions such as sarcopenia,cachexia and malnutrition due to development of cardiac cachexia and pancreatic exocrine insufficiency(PEI),respectively.AIM To explore the evidence regarding the association of CP and heart disease,more specifically CVD and CHF.METHODS A systematic search of MEDLINE,Web of Science and Google Scholar was performed by two independent investigators to identify eligible studies where the connection between CP and CVD was investigated.The search was limited to articles in the English language.The last search was run on the 1st of May 2019.The primary outcomes were:(1)Incidence of cardiovascular event[acute coronary syndrome(ACS),chronic coronary disease,peripheral arterial lesions]in patients with established CP;and(2)Incidence of PEI in patients with CHF.RESULTS Out of 1166 studies,only 8 were eligible for this review.Studies regarding PEI and CHF showed an important incidence of PEI as well as associated malabsorption of nutritional markers(vitamin D,selenium,phosphorus,zinc,folic acid,and prealbumin)in patients with CHF.However,after substitution of pancreatic enzymes,it seems that,at least,loss of appetite was attenuated.On the other side,studies investigating cardiovascular events in patients with CP showed that,in CP cohort,there was a 2.5-fold higher incidence of ACS.In another study,patients with alcohol–induced CP with concomitant type 3c diabetes had statistically significant higher incidence of carotid atherosclerotic plaques in comparison to patients with diabetes mellitus of other etiologies.Earlier studies demonstrated a marked correlation between the clinical symptoms in CP and chronic coronary insufficiency.Also,statistically significant higher incidence of arterial lesions was found in patients with CP compared to the control group with the same risk factors for atherosclerosis(hypertension,smoking,dyslipidemia).Moreover,one recent study showed that PEI is significantly associated with the risk of cardiovascular events in patients with CP.CONCLUSION Current evidence implicates a possible association between PEI and malnutrition in patients with CHF.Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF.On the other hand,CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. | Sara Nikolic Ana Dugic Corinna Steiner Apostolos V Tsolakis Ida Marie Haugen Lofman J-Matthias Lohr Miroslav Vujasinovic | 2019 | World Journal of Gastroenterology2019，25，44： | 2 |
| 9 | Mycobacterium tuberculosis: immune evasion, latency and reactivation显示文摘 | Gupta A Kaul A Tsolaki AG | 2012 | Immunobiology2012，217，3： | 1 |
| 10 | An Insight into the Di- verse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adap- tive Immunity 显示文摘 | Nayak A Dodagatta-Marri E Tsolaki AG | 2012 | Front Immunol2012，3，： | 1 |
| 11 | Combustion characteristics and emissions of Fischer-Tropsch diesel fuels in IC engines 显示文摘 | GILL S S TSOLAKIS A DEARN K D | 2011 | Progress in Energy and Combustion Science2011，37，： | 1 |
| 12 | Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease显示文摘 | Irvin M. Modlin Bjorn I. Gustafsson Steven F. Moss Marianne Pavel Apostolos V. Tsolakis Mark Kidd | 2010 | Annals of Surgical Oncology2010，，9： | 1 |
| 13 | Combustion char- acteristics and emissions of Fischer-Tropsch diesel fuels in IC engines 显示文摘 | Gill S S Tsolakis A Deam K D | 2011 | Progress in Energy and Combustion Science2011，37，4： | 1 |
| 14 | Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model 显示文摘 | Tsolaki AG Nagy J Leiva S | 2013 | Mol Immunol2013，54，34： | 1 |
| 15 | Human abdominal aortic aneurysm is characterized by decreased versican concentration and specific downregulation of versican isoform V显示文摘 | Theocharis AD Tsolakis I Hjerpe A | | 0，，： | 1 |
| 16 | Stable association between strains of Mycobacterium tuberculosis and their human host populations显示文摘 | Hirsh A E Tsolaki A G DeRiemer K | 2004 | Proc Natl Acad Sci U S A2004，101，14： | 1 |
| 17 | Particulate matter size distribution in the exhaust gas of a modern diesel engine fuelled with a biodiesel blend 显示文摘 | Chuepeng S Xu H M Tsolakis A | 2011 | Biomass and Bioenergy2011，35，10： | 1 |
| 18 | No association of a non-synonymous PLAU polymorphisms with Alzheimer's disease and disease related traits显示文摘 | Papassotiropoulos A Tsolaki M Wollmer MA | | 0，，： | 1 |
| 19 | No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits显示文摘 | Tsolaki M Wollmer M A | 2005 | Am J Med Genet B Neuropsychiatr Genet2005，132，： | 1 |
| 20 | Econometric modelling of second-hand ship prices显示文摘 | TSOLAKIS S D CRIDLAND C HARALAMBIDE H E | | 0，，05： | 1 |
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