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| 1 | Potential implications of Helicobacter pylori-related neutrophil-activating protein显示文摘Helicobacter pylori (H.pylori) virulence factors promote the release of various chemoattractants/inflammatory mediators,including mainly the neutrophilattractant chemokine interleukin-8 and neutrophilactivating protein (NAP),involved in H.pylori-induced gastric pathologies.Co-administration of Chios mastic gum (CMG),which inhibits H.pylori NAP,with an H.pylori eradication regimen might add clinical benefits against H.pylori-related gastric pathologies,but possibly not CMG as main therapy.Although H.pylori NAP and other H.pylori-related cytotoxins [i.e.,vaculating cytotoxin (VacA)] appear to play a major role in generating and maintaining the H.pylori-associated gastric inflammatory response and H.pylori NAP is a promising vaccine candidate against H.pylori infection (H.pylori-I),concerns regarding its potential drawbacks,particularly neurogenic ones,due to possible crossmimicry,should be considered.Possible cross-mimicry between H.pylori NAP and/or bacterial aquaporin (AQP) and neural tissues may be associated with the anti-AQP-4 antibody-related neural damage in multiple sclerosis (MS)/neuromyelitis optica patients.Moreover,the sequence homology found between H.pylori VacA and human Na+/K+-ATPase A subunit suggests that antibodies to VacA involve ion channels in abaxonal Schwann cell plasmalemma resulting in demyelination in some patients.A series of factors have been implicated in inducing blood-brain barrier (BBB) disruption,including inflammatory mediators (e.g.,cytokines and chemokines induced by H.pylori-I) and oxidative stress.BBB disruption permits access of AQP4-specific antibodies and T lymphocytes to the central nervous system,thereby playing a major role in multiple sclerosis pathogenesis.Relative studies show a strong association between H.pylori-I and MS.H.pylori-I induces humoral and cellular immune responses that,owing to the sharing of homologous epitopes (molecular mimicry),cross-react with components of nerves,thereby contributing and perpetuating neural tissue damage.Finally,H.pylori NAP also plays a possible pathogenetic role in both gastric and colon oncogenesis. | Jannis Kountouras Christos Zavos Georgia Deretzi Emmanuel Gavalas Dimitrios Chatzopoulos Panagiotis Katsinelos Elena Tsiaousi Stergios Gagalis Stergios A Polyzos Ioannis Venizelos | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 2 | Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease显示文摘 | Jannis Kountouras Marina Boziki Emmanuel Gavalas Christos Zavos Nikolaos Grigoriadis Georgia Deretzi Dimitrios Tzilves Panagiotis Katsinelos Magda Tsolaki Dimitrios Chatzopoulos Ioannis Venizelos | 2009 | Journal of Neurology2009，，5： | 2 |
| 3 | A concept on the role of Helicobacter pylori infection in autoimmune pancreatitis显示文摘 | Kountouras J Zavos C Chatzopoulos D | 2005 | J CeⅡ Mol Med2005，9，1： | 1 |
| 4 | Reactive oxygen metabolites and upper gastrointestinal diseases显示文摘 | Kountouras J Chatzopoulos D Zavos C | 2001 | Hepatogastroenterology2001，48，： | 1 |
| 5 | Load application induces changes in the expression levels of Box-9, FGFR-3 and VEGF in condylar ehon- drocytes显示文摘 | Papadopoulou AK Papachristou D J Chatzopoulos SA | 2007 | FEBS Lett2007，581，10： | 1 |
| 6 | Multiple desmoid tumors in a patient with familial adenomatous polyposis caused by the novel W421X mutation显示文摘 | Ioannidis O Paraskevas G Chatzopoulos S | 2012 | Rev Esp Enferm Dig2012，104，3： | 1 |
| 7 | Inflammatory markers and plaque morphology: Anoptical coherence tomography study显示文摘 | Bouki KP Katsafados MG Chatzopoulos DN | 2012 | Int J CardioI2012，154，3： | 1 |
| 8 | Primary open-angle glaucoma:pathophysiology and treatment显示文摘 | Kountouras J Zavos C Chatzopoulos D | 2004 | Lancet2004，364，： | 1 |
| 9 | Load appli- cation induces changes in the expression levels of Sox-9, FGFR-3 and VEGF in condylar chondrocytes 显示文摘 | Papadopoulou AK Papachristou DJ Chatzopoulos SA | 2007 | Febs Litters2007，58，10： | 1 |
| 10 | From design to manufacturing for mass customization显示文摘 | Tsigkas A Chatzopoulos C | 2009 | Advances in Production Engineering & Management2009，，1： | 1 |
| 11 | 2-Hydroxyethyl methacrylate (HEMA):chemical properities and applications in biomedical fields显示文摘 | Jean Pierre Montheard Michel Chatzopoulos Daniel Chappard | 1992 | J Macromolecules Sci Rev Macromolecule Chem Phys1992，32，1： | 1 |
| 12 | Molecular mechanisms associated with aggressiveness of alpha-fetoprotein-positive gastric cancer 显示文摘 | KOUNTOURAS J ZAVOS C CHATZOPOULOS D | 2007 | Hepatogastroenterology2007，54，74： | 1 |
| 13 | Apoptotic and anti-angiogenic strategies in liver and gastrointestinal malignancies显示文摘 | KOUNTOURAS J ZAVOS C CHATZOPOULOS D | 2005 | J Surg Oncol2005，90，4： | 1 |
| 14 | 显示文摘 | Feugeas G Olschwans D and Chatzopoulos M | 1967 | C R Acad Sci Paris Ser C1967，265，2： | 1 |
| 15 | Apoptotic and anti-angiogenic strategic in liver and gastrointestinal malignancies显示文摘 | Kountouras J Zavos C Chatzopoulos B | 2005 | Surgical Oncol2005，90，： | 1 |
| 16 | Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy : A systematic review and meta-analysis显示文摘 | Chatzopoulos GS Doufexi AE KaIogirou F | 2016 | Med Oral Patol Oral Cir Bucal2016，21，1： | 1 |
| 17 | Apoptotic and anti-angiogenic strategies in liver and gastrointestinal malignancies显示文摘 | Kountouras J Zavos C Chatzopoulos D | 2005 | J Surg Oncol2005，90，4： | 1 |
| 18 | Giant bilateral symptomatic adrenal myelolipomas associated with congenital adrenal hyperplasia 显示文摘 | Ioannidis O Papaemmanouil S Chatzopoulos S | 2011 | Pathol Oncol Res2011，17，3： | 1 |
| 19 | C-reactive protein, interleukin 6, and N-terminal pro- brain natriuretic peptide following cardioversion of atrial fibrillation :is there a role of biomarkers in arrhythmia recurrence? 显示文摘 | PSYCHARI S N CHATZOPOULOS D ILIODROMITIS E K | 2011 | Angiology2011，62，4： | 1 |
| 20 | Inflammatory markers and plaque morphology:Anoptical coherence tomography study显示文摘 | Bouki KP Katsafados MG Chatzopoulos DN | 2012 | Int J Cardiol2012，154，3： | 1 |
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