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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Functional consequences of overexpressing the gap junction Cx43 in the cardiogenic potential of pluripotent human embryonic stem cells显示文摘 | Moore JC Tsang SY Rushing SN | 2009 | Biochem Biophys Res Commun2009，377，1： | 1 |
| 3 | Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation显示文摘 | Chan YC Leung FP Wong WT Tian XY Yung LM Lau CW Tsang SY Yao X Chen ZY Huang Y | | 0，，： | 1 |
| 4 | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium -dependent relaxation in rat aorta显示文摘 | Wong WT Ng CH Tsang SY | 2009 | Nutr Metab Cardiovase Dis2009，21，3： | 1 |
| 5 | Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma 显示文摘 | LIN SY TSANG NM KAO SC | 2001 | Head Neck2001，23，： | 1 |
| 6 | Laparoscopic sphincter-preserving total mesorectal excision with colonic J-pouch reconstruction: five-year results 显示文摘 | Tsang WWC Chung CC Kwok SY | 2006 | Ann Surg2006，243，3： | 1 |
| 7 | Visceral periadven*itial adipose tissue regulates arterial tone of mesenteric arteries 显示文摘 | Verlohren S Dubrovska G Tsang SY | 2004 | Hypertension2004，44，27： | 1 |
| 8 | Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma显示文摘 | Lin SY Tsang NM Kao SC | 2001 | Head Neck2001，23，3： | 1 |
| 9 | Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma 显示文摘 | Lin SY Tsang NM Kao SC | 2001 | Head NeekJ Sei Spec2001，23，： | 1 |
| 10 | Dissecting the structural and functional roles of the S3-S4 linker of pacemaker(hyperpolarization-activated cyclic nucleotide-modulated)channels by systematic length alterations显示文摘 | Tsang SY Lesso H Li RA | 2004 | J Biol Chem2004，279，43： | 1 |
| 11 | Development of effective therapeutics targeting the GABAA receplor: naturally occurring alternatives显示文摘 | TSANG SY CARL P XUE H | 2004 | Curr Pharmaceut Design2004，10，9： | 1 |
| 12 | Laparoscopic sphincter-preserving total mesorectal excision with colonic J-pouch reconstruction: five-year results显示文摘 | Tsang WW Chung CC Kwok SY | 2006 | Ann Sur~2006，243，3： | 1 |
| 13 | Biological properties of baicalein in cardiovascular system显示文摘 | Huang Y Tsang SY Yao X | 2005 | Curr Drug Targets Cardiovasc Haematol Disord2005，5，2： | 1 |
| 14 | Laparoscopic sphincter-preserving totalmesorectal excision with colonic J-pouch re-construction: five-year results显示文摘 | Tsang WW Chung CC Kwok SY | 2006 | Ann Surg2006，243，3： | 1 |
| 15 | Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries显示文摘 | Verlohren S Dubrovska G Tsang SY | 2004 | Hypertension2004，44，3： | 1 |
| 16 | Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries 显示文摘 | Verlohren S Dubrovska G Tsang SY | 2004 | Hypertension2004，44，3： | 1 |
| 17 | Biological properties of baicalein in cardiovascular system显示文摘 | Huang Y Tsang SY Yao X | 2005 | Curr Drug Targets Cardiovasc Haematol Disord2005，5，2： | 1 |
| 18 | Laparoscopic sphincter-preserving total mesorectal excision with colonic J-pouch reconstruction:five-year results显示文摘 | Chung CC Kwok SY | 2006 | Ann Surg2006，243，3： | 1 |
| 19 | Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis 显示文摘 | Tsang WP Chau SY Kong SK | 2003 | Life Sci2003，73，16： | 1 |
| 20 | Therapeutic potential of wogonin: a naturally occurring flavonoid 显示文摘 | Tai MC Tsang SY Chang LY | 2005 | CNS Drug Rev2005，11，2： | 1 |
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