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| 1 | A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma显示文摘 | Gregory L. Beatty Drew A. Torigian E. Gabriela Chiorean Babak Saboury Alex Brothers Abass Alavi Andrea B. Troxel Weijing Sun Ursina R. Teitelbaum Robert H. Vonderheide Peter J. O’Dwyer | 2013 | Clinical Cancer Research2013，，22： | 6 |
| 2 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 3 | Comparison of in- terpolating methods for image resampling 显示文摘 | PARKER J A KENYON R V TROXEL D E | 1983 | IEEE Transactions on Medical Imaging1983，2，1： | 1 |
| 4 | A retrospective study of alveolar cleft grafting 显示文摘 | Troxell JB Fonseca RJ Osbon DB | 2004 | J Oral Maxillofac Surg2004，40，4： | 1 |
| 5 | Evaluation of C4d staining in liver and small intestine allografts显示文摘 | Troxell M L Higgins J P Kambham N | 2006 | Arch Pathol Lab Med2006，130，10： | 1 |
| 6 | Comparison of InterpolatingMethods for Image Resampling显示文摘 | ? Parker J A Kenyon R V Troxel D E | 1983 | IEEE Transactions Medical Ima-ging1983，2，1： | 1 |
| 7 | A computer-assisted technique for 24-hour esophageal monitoring显示文摘 | Rebecca B. Troxell PA-C Sarah R. Kohn BA Dr. James E. Gray MD Richard W. Welch MD Edward D. Harloe BS Raj K. Goyal MD | 1982 | Digestive Diseases and Sciences1982，，12： | 1 |
| 8 | c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein 显示文摘 | Sicari B M Troxell R Salim F | 2012 | Endocrinology2012，153，2： | 1 |
| 9 | Test for carcinogenicity of metallic compounds by the pulmonary tumor response in strain A mice显示文摘 | Stoner GD Shimkin MB Troxell MC | 1976 | Cancer Res1976，36，5： | 1 |
| 10 | Sleep symp- toms predict the development of the metabolic syndrome显示文摘 | Troxel WM Buysse DJ Matthews KA | 2010 | Sleep2010，33，12： | 1 |
| 11 | Renal intrapelvic pressure during percutaneous nephrolithotomy and its correlation with the development of postoperative fever显示文摘 | Troxel SA Low RK | 2002 | J Urol2002，168，： | 1 |
| 12 | pl61NK4A immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia 显示文摘 | KONG CS BALZER BL TROXELL ML | 2007 | Am I Surg Pathol2007，31，1： | 1 |
| 13 | Pure mucinous carcinoma of the breast显示文摘 | Komenaka I K EITamer M B Troxel A | 2004 | Am J Surg2004，187，： | 1 |
| 14 | Marital happiness andsleep disturbances in a multi-ethnic sample of middle-agedwomen显示文摘 | Troxel WM Buysse DJ Hall M | 2009 | Behav Sleep Med2009，，7： | 1 |
| 15 | Laparoscopy versus dorsal lumbotomy for ureteropelvic junction obstruction repair显示文摘 | Troxel S Das S Helfer E | 2006 | J Urol2006，176，3： | 1 |
| 16 | The minimum span of L(2,1)-labelings of certain generalized Petersen graphs显示文摘 | Adams S S Cass J Tesch M Troxell D S Wheeland C | 2007 | Discrete Applied Mathematics2007，155，： | 1 |
| 17 | Phase Ⅱ trial of sorafenib in advanced thyroid cancer显示文摘 | Gupta-Abramson V Troxel AB Nellore A | 2008 | J Clin Oncol2008，26，29： | 1 |
| 18 | Comparison of interpolating methods for image resampling显示文摘 | A J Parker R V Kenyon D Troxel | 1983 | IEEE Transactions on Medical Imaging1983，2，1： | 1 |
| 19 | Tensile deformation and fracture behavior of an oxide dispersion strengthened copper alloy显示文摘 | Srivatsan T S Narendra N Troxell J D | 2000 | Materials and Design2000，21，3： | 1 |
| 20 | Renal intrapelvic pressure during percutaneous nephrolithotomy and its correlation with the development of postoperative fever显示文摘 | Troxel SA Low RK | 2002 | J Urol2002，168，4： | 1 |
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