|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 2 | Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice显示文摘AIM: Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor (VEGF) via stimulating endothelial cell proliferation, migration, and survival. Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distinct tumor entities. Here, we tested a recombinant adenovirus, AdsFIt1-3, that encodes an antagonistically acting fragment of the VEGF receptor 1 (Flt-1), for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice. METHODS: Murine colorectal carcinoma cells (CT26) were inoculated subcutaneously into Balb/c mice for in vivo studies. Tumor size and survival were determined. 293 cell line was used for propagation of the adenoviral vectors. Human lung cancer line A549 and human umbilical vein endothelial cells were transfected for in vitro experiments. RESULTS: Infection of tumor cells with AdsFlt1-3 resulted in protein secretion into cell supernatant, demonstrating correct vector function. As expected, the secreted sFlt1-3 protein had no direct effect on CT26 tumor cell proliferation in vitro, but endothelial cell function was inhibited by about 46% as compared to the AdLacZ control in a tube formation assay. When AdsFlt1-3 (5×109 PFU/animal) was applied to tumor bearing mice, we found a tumor inhibition by 72% at d 12 after treatment initiation. In spite of these antitumoral effects, the survival time was not improved. According to reduced intratumoral microvessel density in AdsFIt1-3-treated mice, the antitumor mechanism can be attributed to angiostatic vector effects. We did not detect increased systemic VEGF levels after AdsFlt1-3 treatment and liver toxicity was low as judged by serum alanine aminotransferase determination. CONCLUSION: In this study we confirmed the value of a systemic administration of AdsFIt1-3 to block VEGF signaling as antitumor therapy in an experimental metastatic colorectal carcinoma model in mice. | Volker Schmitz Miroslaw Kornek Tobias Hilbert Christian Dzienisowicz Esbher Raskopf Christian Rabe Tilman Sauerbruch Cheng Qian Wolfgang H Caselmann | 2005 | World Journal of Gastroenterology2005，11，28： | 4 |
| 3 | Inactivation of human kidney cells by high-energy monoenergetic heavy-ion beams 显示文摘 | Blakely E A Tobias C A Yang T C H | 1979 | Radiation Research1979，80，1： | 1 |
| 4 | The role of dietary zinc in modifying the onset and severity of spontaneous diabetes in the BB Wister rat显示文摘 | Tobia M H Zdanowicz M M Wingertzahn M A | 1998 | Mol Genet Metab1998，63，3： | 1 |
| 5 | Can the Proximal Femoral Nail be Improved?显示文摘 | Inger B. 1 8 Phone Fax e-mail: Schipper MD PhD Roger K. J. Simmermacher Tobias Hüttl R?bi Frigg Peter Messmer Michael Schütz Andreas Lenich Chris Werken | 2005 | European Journal of Trauma2005，，3： | 1 |
| 6 | Pituitary irradiation with high-energy proton beams a preliminary report显示文摘 | Tobias C A Lawrence J H Born J L | 1958 | Cancer Research1958，18，2： | 1 |
| 7 | Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice显示文摘Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory diseases.While TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory effects.In this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced arthritis.Mice with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second day.Two days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were analyzed.Mice were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by histology.Treatment with TNCscTNF80 increased arthritis-induced myelopoiesis.Little effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid organs.Upon treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph nodes.In addition,the expression of TNFR2 on Treg cells was enhanced.The clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of therapy.The histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control mice.Activation of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis. | Vanessa Lamontain Tobias Schmid Dorothea Weber-Steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H Straub Daniela N Männel | 2019 | Cellular & Molecular Immunology2019，16，1： | 1 |
| 8 | Challenges and opportunities in mapping land use intensity globally显示文摘 | Tobias Kuemmerle Karlheinz Erb Patrick Meyfroidt Daniel Müller Peter H Verburg Stephan Estel Helmut Haberl Patrick Hostert Martin R. Jepsen Thomas Kastner Christian Levers Marcus Lindner Christoph Plutzar Pieter Johannes Verkerk Emma H van der Zanden Anet | 2013 | Current Opinion in Environmental Sustainability2013，，： | 1 |
| 9 | High-Temperature Contact Formation on n-Type Silicon:Basic Reactions and Contact Model for Seed-Layer Contacts显示文摘 | Matthias H(o)rteis Tobias Gutberlet Armin Reller | 2010 | Advanced Functional Materials2010，20，3： | 1 |
| 10 | Long-term follow-up HbeAG-Positive Patients treated with interferon alfa for chronic hepatitis B显示文摘 | CLASUS N TOBIAS H STAFAN L | 1996 | New Engl J Med1996，334，4： | 1 |
| 11 | Resveratrol reduces endothelial oxidative stressby modulating the gene expression of superoxide dis-mutase 1 (SOD1),glutathione peroxidase 1 (GPxl )and NADPH oxidase subunit (Nox4 )显示文摘 | Spanier G Xu H Xia N? Tobias S Deng S WojnowskiL | 2009 | J PhysiolPharmacol2009，60，4： | 1 |
| 12 | Effects of annealing on the uanomorphology and performance of poly(alkylthiophene) : fullerene bulk-hetero- junction solar cells 显示文摘 | Le H N Harald H Tobias E | 2007 | Adv Fun Mater2007，17，7： | 1 |
| 13 | Design and impact of an intraoperative pathway:A new operating room model for team-based practice显示文摘 | Lee B T Tobias A M Yueh J H | 2008 | J Am Coll Surg2008，207，6： | 1 |
| 14 | Development of individual three-dimensional bone substitutes using 'selective laser melting' 显示文摘 | Dirk A H Tobias W Matthias W | 2003 | European Journal of Trauma2003，29，4： | 1 |
| 15 | Analyzing price and product strate- gies with a comprehensive system dynamics model: A case study from the capital goods industry 显示文摘 | ANDREAS GROf3LER TOBIAS LOPSINGER MYRJAM STOTZ WORNER H | 2008 | Journal of Busi- ness Research2008，61，11： | 1 |
| 16 | Computer aided tumor resection in the pelvis显示文摘 | Christian Krettek Jens Geerling Leonard Bastian Musa Citak Ferdinand Rücker Daniel Kendoff Tobias Hüfner | 2004 | Injury2004，，： | 1 |
| 17 | Filter-bank-based narrowband interference detection and suppression in spread spectrum systems显示文摘 | Tobias H S and Markku R | 2004 | EURASIP Journal on Applied Signal Processing2004，2004，8： | 1 |
| 18 | On-line measure- ments of diesel nanoparticle composition and volatil- ity显示文摘 | Sakurai H Tobias H J Park K | 2003 | Atmosphere Environment2003，37，： | 1 |
| 19 | T cells with a CD4^+ CD25^+ regulatory phenotype suppress in vitro proliferation of virusspecific CD8^+ T cells during chronic hepatitis C virus infection显示文摘 | Tobias B Hans C S Christoph N H | 2005 | J Virol2005，79，12： | 1 |
| 20 | On the stability of randomly sampled systems显示文摘 | Kushner H J Tobias | | 0，，04： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员