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| 1 | Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells显示文摘AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa. | Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Adverse Effects of Low Dose Amiodarone: A Meta-Analysis显示文摘 | Vicken R Vorperian Thomas C Havighurst Stephen Miller Craig T January | 1997 | Journal of the American College of Cardiology1997，，3： | 2 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 6 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 7 | T - cell tolerance or function is determined by combinatorial costimulatory signals显示文摘 | Nurieva R Thomas S Nguyen T | 2006 | EMBO J2006，25，11： | 1 |
| 8 | Carbon and nitrogen dynamics in ageing earthworm casts in grasslands of the eastern plains of Colombia 显示文摘 | DECAENS T RANGEL A F ASAKAWA N THOMAS R J | 1999 | Biology and Fertility of Soils1999，30，1： | 1 |
| 9 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 10 | Management of phacolytic glaucoma: experience of 135 cases 显示文摘 | Braganza A Thomas R George T | 1998 | Indian J Ophthalmol1998，46，3： | 1 |
| 11 | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase 显示文摘 | Thoma R Schulz-Gasch T D'Arcy B | 2004 | Nature2004，432，7013： | 1 |
| 12 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 13 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 14 | The mysterious art and science of knowledge-worker performance 显示文摘 | DAVENPORT T H THOMAS R J CANTRELL S | 2002 | Sloan Management Review2002，44，1： | 1 |
| 15 | Leptin modulates both resorption and formation while preventing disuse-induced bone loss in tail-suspended female rats显示文摘 | Thomas T Martin A de Vittoris R | 2003 | J Bone Miner Res2003，18，2： | 1 |
| 16 | 显示文摘 | Velusamy M Justin Thomas K R Lin J T | 2005 | Org Lett2005，，7： | 1 |
| 17 | Correlations for thermal contact conductance in vacuum 显示文摘 | Thomas T R Probert S D | 1972 | Trans ASME J of Heat Transfer1972，21，8： | 1 |
| 18 | Acute oxaliplatin-induced peripheral nerve hyperexcitability 显示文摘 | WILSON R H LEHKY T THOMAS R R | 2002 | Clin Oncol2002，20，7： | 1 |
| 19 | Water hyacinth: a major neglected resource, material science, wind energy 显示文摘 | Thomas T H Eden R D | 1990 | BiomasS Technology1990，3，： | 1 |
| 20 | Efficient Red - Emitting Cyclometalated Iridium (III ) Complexes Containing Lepidine - Based Ligands 显示文摘 | Thomas K R Velusamy M Lin J T | 2005 | Inorg Chem2005，44，16： | 1 |
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