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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 3 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 4 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 5 | Multicell converters: basic concepts and industry applications显示文摘 | MEYNARD T A FOCH H THOMAS P | 2002 | IEEE Trans on Industrial Electronics2002，49，5： | 1 |
| 6 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 7 | Effects of porcine circovims Type 2 (PCV2) maternal antibodies on experimental infection of piglets with PCV2 clinical and diagnostic laboratory immunology显示文摘 | McKeown N E Opriessnig T Thomas P | 2005 | 12:1 347-1 3512005，12，： | 1 |
| 8 | Poly ( amidoamine ) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy 显示文摘 | Majoros I J Thomas T P Mehta C B | 2005 | Journal of Medicinal Chemistry2005，48，： | 1 |
| 9 | Identification of polymorphic outer membrane protein of Chlamydia psittaic 6BC 显示文摘 | Regina J T David L Thomas P H | 2001 | Infect and Immun2001，69，： | 1 |
| 10 | Coarse woody debris in Douglas-fir forests of western Oregon and Washington显示文摘 | Spies T A Franklin J P Thomas T B | 1988 | Ecolo- gy1988，69，： | 1 |
| 11 | Evidence for downy mildew races incucumber tested in Asia,Europe,and North America显示文摘 | SHETTY N V WEHNER T C THOMAS C E D0RUCH0WSKI RW VASANTH SHETTY K P | 2002 | ScientiaHorticulturae2002，94，3： | 1 |
| 12 | Heat shock protein expression in fish显示文摘 | Iwama G K Thomas P T Forsyth R B | 1998 | Reviews in Fish Biology and Fisheries1998，8，1： | 1 |
| 13 | Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy显示文摘 | MAJOROS I J THOMAS T P MEHTA C B | | 0，，19： | 1 |
| 14 | New Orange-Red Emitting Phosphor La3 NbOT: Eu3 + under Blue Excitation 显示文摘 | Francis L T Ran P P Thomas M | 2012 | Materials Letters2012，81，： | 1 |
| 15 | The ionic KAl13molecule:a stepping stone to cluster assembled materials显示文摘 | ZHENG W J THOMAS O C LIPPA T P | 2006 | J Chem Phys2006，124，14： | 1 |
| 16 | Optimizing esteri- fieation of safflower, cottonseed, castor and used cottonseed oils显示文摘 | THOMAS T P BIRNEY D M AULD D L | 2013 | Industrial Crops and Products2013，41，： | 1 |
| 17 | Potential stem cell marker CD44 is constitutively expressed in permanent cell lines of head and neck cancer显示文摘 | Ralph P Nadine W Thomas T | 2008 | In Vivo2008，22，1： | 1 |
| 18 | Genetic transformation of major wine grape cultivars of Vitis vinifera L显示文摘 | Iocco P Franks T Thomas M R | | 0，，： | 1 |
| 19 | Heat shock protein expression in fish显示文摘 | IWAMA G K THOMAS P T FORSYTH R B | 1998 | Rev Fish Biol Fish1998，8，： | 1 |
| 20 | Characterization of two nuclear androgen receptors in Antarctic croaker:comparison of their biochemical properties and binding specificities显示文摘 | Sperry T S Thomas P | 1999 | J Endocrinol1999，140，： | 1 |
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