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| 1 | 降压治疗与脑卒中二级预防:脑卒中后降压治疗研究显示文摘目的评价对于中国患者脑血管病后降压治疗是否可以预防脑卒中再发。方法采取双盲、安慰剂对照的试验方法,将患者随机分入对照组(n=2825)和干预组(吲达帕胺2.5 mg/d,n=2840)。一级终点事件为致死或非致死性再发脑卒中,二级终点事件为主要的致死或非致死心血管病事件。结果平均收缩压和舒张压分别为153.8和92.8 mm Hg。在随访中期(第2年),干预组收缩压/舒张压较对照组平均下降了6.8/3.3 mm Hg。干预组总共有159例再发脑卒中,对照组为219例(干预组HR=0.70;95%CI0.57~0.86;P<0.01)。干预组有199例发生心血管病事件,对照组为258例(HR=0.74;95%CI0.62~0.89;P=0.002)。结论吲达帕胺降压治疗可以降低中国人脑血管病患者再发脑卒中和心血管病事件。 | 王增武 刘力生 龚兰生 张宇清 Lutgarde Thijs Jan A.Staessen 王继光 | 2010 | 中华高血压杂志2010，18，4： | 15 |
| 2 | 中国宜昌王家湾晚奥陶世五峰组几丁虫的初步研究显示文摘中国宜昌王家湾北剖面已被提名为奥陶系赫南特阶的全球候选层型剖面。为此著者分析了王家湾地区,特别是王家湾南和王家湾小河边奥陶—志留系间相关地层共20个层位的几丁虫样品。初步研究的结果表明,王家湾赫南特阶之下,相当奥陶纪第6个阶顶部,即五峰组中部产出的几丁虫与美国内华达中部Vnini河谷以及加拿大极区Cape Mannig的Ordochitina nevadensis 和Nevadachitina vininica 几丁虫带的分子可以进行对比。 | Thijs R.A.VANDENBROUCKE 陈旭 Jacques VERNIERS | 2005 | 古生物学报2005，44，2： | 8 |
| 3 | Challenges in diagnosing adhesive small bowel obstruction显示文摘Adhesive small bowel obstruction(ASBO)is the most frequently encountered surgical disorder of the small intestine.Up to 80%of ASBO cases resolve spontaneously and do not require invasive treatment.It is important to identify such patients that will benefit from conservative treatment in order to prevent unnecessarily exposing them to the risks associated with surgical intervention,such as morbidity and further adhesion formation.For the remaining ASBO patients,timely surgical intervention is necessary to prevent small bowel strangulation,which may cause intestinal ischemia and bowel necrosis.While early identification of these patients is key to decreasing ASBO-related morbidity and mortality,the non-specific signs and laboratory findings upon clinic presentation limit timely diagnosis and implementation of appropriate clinical management.Combining the clinical presentation findings with those from other diagnostic imaging modalities,such as abdominal X-ray,computed tomography-scan and water-soluble contrast studies,will improve diagnosis of ASBO and help clinicians to better evaluate the potential of conservative management as a safe strategy for a particular patient.Nonetheless,patients who present with moderate findings by all these approaches continue to represent a challenge.A new diagnostic strategy is urgently needed to further improve our ability to identify early signs of strangulated bowel,and this diagnostic modality should be able to indicate when surgical management is required.A number of potential serum markers have been proposed for this purpose,including intestinal fatty acid binding protein andα-glutathione S transferase.On-going research is attempting to clearly define their diagnostic utility and to optimize their potential role in determining which patients should be managed surgically. | Thijs R van Oudheusden Bart AC Aerts Ignace HJT de Hingh Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 4 | Urban Physics: Effect of the micro-climate on comfort, health and energy demand显示文摘 | Peter Moonen Thijs Defraeye Viktor Dorer Bert Blocken Jan Carmeliet | 2012 | Frontiers of Architectural Research2012，1，3： | 4 |
| 5 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 6 | 预测急性脑卒中缺血半暗带的最优Tmax阈值显示文摘背景:挽救缺血半暗带对减少梗死范围有重要意义,一般以PWI与DWI的不匹配区域来评估半暗带。但PWI评估的低灌注范围可能会包括良性缺血区,从而使评估所得的半暗带体积大于实际值。为减少这种弊端,近来引入一新的参数:PWI的达峰时间(Tmax)阈值。Tmax为PWI成像信号强度.时间曲线中从对比剂开始出现到对比剂浓度达到峰值的时间。以对侧相应部位正常脑组织的Tmax为参考,脑组织中Tmax延迟超过阈值的区域即为PWI病灶区。 | 0livot JM Mlynash M Thijs VN | 2010 | 中华神经科杂志2010，43，6： | 3 |
| 7 | 国际卒中遗传学联盟的推荐意见(第1部分):标准化表型数据收集显示文摘与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟( International Stroke Genetics Consortium, ISGC; http://www. strokegenetics.org),其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000~200000个样本。为了达到这个样本量,需要进行更为广泛的协作。 | Jennifer J. Majersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan M. Edip Gurol Ame G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kamal Paul Bentley Joanna M. Wardlaw Ynte M. Ruigrok Thomas W.K Battey Reinhold Schmidt Joan Montaner Anne-Katrin Giese Jaume Roquer Jordi Jimenez-Conde Chaeyoung Lee Hakan Ay Juan Jose Martin 李海峰 岳耀先 徐军 | 2015 | 国际脑血管病杂志2015，23，9： | 3 |
| 8 | Ambulatory Arterial Stiffness Index as a Predictor of Cardiovascular Mortality in the Dublin Outcome Study显示文摘 | Eamon Dolan Lutgarde Thijs Yan Li Neil Atkins Patricia McCormack Sean McClory Eoin O’Brien Jan A. Staessen Alice V. Stanton | 2006 | Hypertension2006，，3： | 3 |
| 9 | Giant cystic lymphangioma originating from the lesser curvature of the stomach显示文摘Cystic lymphangiomas are rare benign tumors.Most frequently occurring in children and involving the neck or axilla,these tumors are much less common in adults and very rarely involve the abdomen.The known congenital and acquired(traumatic)etiologies result in failure of the lymphatic channels and consequent proliferation of lymphatic spaces.This case report describes a very rare case of a giant mesenteric cystic lymphangioma in an adult male with no clear etiology and successful resolution by standard radical resection.A previously healthy 44-year-old male presented with a 6-wk history of progressive upper abdominal pain,vomiting,anorexia and unintentional weight loss accompanied by rapid abdominal distension.A palpable mass was detected upon physical examination of the distended abdomen and abdominal computed tomography scan showed a giant multilobulated cystic process,measuring 40 cm in diameter.Exploratory laparotomy revealed an enormous cystic mass containing 6 L of serous fluid.The process appeared to originate from the lesser omentum and the lesser curvature of the stomach.Radical resection of the tumor was performed along with a partial gastrectomy to address potential invasion into the adjacent tissues.Histological analysis confirmed the diagnosis of a multicystic lymphangioma.The postoperative recovery was uneventful and the patient was discharged after 6 d.At 3-mo follow-up,the patient was in good health with no signs of recurrence. | Thijs Ralf van Oudheusden Simon Willem Nienhuijs Thomas Bernard Joseph Demeyere Michael Derek Philip Luyer Ignace Hubertus Johannes Theodorus de Hingh | 2013 | World Journal of Gastrointestinal Surgery2013，5，10： | 3 |
| 10 | TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading显示文摘 | Thijs W.H. Pols Mitsunori Nomura Taoufiq Harach Giuseppe Lo Sasso Maaike H. Oosterveer Charles Thomas Giovanni Rizzo Antimo Gioiello Luciano Adorini Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2011 | Cell Metabolism2011，，6： | 3 |
| 11 | 左心室舒张功能的遗传性和其他影响因素:以家庭为基础的人口研究显示文摘确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法:随机抽取316个家庭样本,包括452名父母和600名后代,平均年龄分别为58.5和33.3岁, | 刘莉 叶鹏 Kloch-Badelek M Knez J Tikhonoff V Thijs L Sakiewicz W Ryabikov A Stolarz-Skrzypek K Jin Y Malyutina S Casiglia E Narkiewicz K Czarnecka D Kawecka-Jaszcz K Staessen JA Kuznetsova T | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 12 | Cervical artery dissection: Trauma and other potential mechanical trigger events显示文摘 | Stefan T. Engelter Caspar Grond-Ginsbach Tiina M. Metso Antti J. Metso Manja Kloss Stephanie Debette Didier Leys Armin Grau Jean Dallongeville Marie Bodenant Yves Samson Valeria Caso Alessandro Pezzini Leo H. Bonati Vincent Thijs Henrik Gensicke Juan J. M | 2013 | Neurology2013，，21： | 2 |
| 13 | Importance of adapted digestion conditions to simulate in vitro lipid digestion of broilers in different life stages显示文摘In vitro digestion studies demonstrate large potential to gain more and quicker insights into the underlying mechanisms of feed additives,allowing the optimization of feed design.Unfortunately,current in vitro digestion models relevant for broiler chickens lack sufficient description in terms of protocols and standardisation used.Furthermore,no distinction is made between the different life phases of these animals(starter,grower,and finisher).Hence,our research aimed to establish adapted in vitro digestion conditions,corresponding to the 3 life phases in broilers,with specific focus on lipid digestion.The effect of 3 different bile salt concentrations of 2,10,and 20 mM,and 3 different lipase activities of 5,20,and 100 U/mL,on in vitro lipid digestion kinetics were evaluated using a full factorial design.These values were selected to represent starter,grower,and finisher birds,respectively.Our findings showed that the extent of lipid digestion was mainly influenced by lipase activity.The rate of lipid digestion was affected by an interplay between bile salt concentration and lipase activity,due to possible lipase inhibition at certain bile salt concentrations.Overall,this work resulted in 3 in vitro lipid digestion models representative for starter,grower,and finisher birds.In conclusion,this research showed the impact of adapted in vitro digestion conditions on lipid digestion kinetics and thus the need for these conditions relevant for each life phase of broilers. | Daphne Michels Sarah H.E.Verkempinck Agnese Panozzo Karen Vermeulen Marc E.Hendrickx Liesbet Thijs Tara Grauwet | 2023 | Animal Nutrition2023，，1： | 2 |
| 14 | 在急性卒中的血压管理中我们(不)了解什么?显示文摘尽管治疗高血压在预防首发或复发性卒中中的作用不容置疑,但对卒中后最初数小时或数天内的高血压管理仍存在争论。80%的卒中患者在发病后数天内有血压升高,尚缺乏来自随机对照试验的高质量证据指导其治疗。理论上,对卒中发病后的血压管理有正反两方面的争论意见。大多数治疗指南建议根据病理生理学原理不对血压进行处理。但是,对随机试验的事后分析提示血压升高与复发性卒中和高病死率有关,即使在校正混杂因素后亦如此。另一方面,初步研究表明,经过选择的患者亚组人为地升高血压可能是有益的。在本综述中,我们对有关这一课题的最新研究做一概括。 | Annick Verstappen Vincent Thijs 卢林 李义召 | 2006 | 国际脑血管病杂志2006，14，12： | 2 |
| 15 | Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock显示文摘 | Vervloet M Thijs L Hack C | | 0，，： | 2 |
| 16 | Blood Pressure Lowering for Primary and Secondary Prevention of Stroke显示文摘 | Haifeng Zhang Lutgarde Thijs Jan A. Staessen | 2006 | Hypertension2006，，2： | 2 |
| 17 | Blood pressure lowering for primary and secondary prevention of stroke 显示文摘 | Zhang H Thijs L Staessen JA | 2006 | Hypertension2006，48，2： | 1 |
| 18 | PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences 显示文摘 | Lescot M Debais P Thijs G | 2002 | Nucleic Acids Res2002，30，： | 1 |
| 19 | lnterection of the growthhonnone-re- leasing peptides ghrelin and growth hormone-releasingpeptide 6 with the motilin receptor in the rabbit gastric antrum显示文摘 | Depoortere I Thijs T Thielemans L | 2003 | JPharmacol Exp Ther2003，305，2： | 1 |
| 20 | Prognostic value of the morning blood pressure surge in 5645 subjects from populations显示文摘 | Li Y Thijs L Hansen TW | 2010 | Hypertension2010，55，4： | 1 |
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