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| 1 | Hepatocellular carcinoma: Where are we?显示文摘Hepatocellular carcinoma(HCC) is the second cause of death due to malignancy in the world, following lung cancer. The geographic distribution of this disease accompanies its principal risk factors: Chronic hepatitis B virus and hepatitis C virus infection, alcoholism, aflatoxin B1 intoxication, liver cirrhosis, and some genetic attributes. Recently, type Ⅱ diabetes has been shown to be a risk factor for HCC together with obesity and metabolic syndrome. Although the risk factors are quite well known and it is possible to diagnose HCC when the tumor is less than 1 cm diameter, it remains elusive at the beginning and treatment is often unsuccessful. Liver transplantation is thus far considered the best treatment for HCC as it cures HCC and the underlying liver disease. Using the Milan criteria, overall survival after liver transplantation for HCC is about 70% after 5 years. Many attempts have been made to go beyond the Milan Criteria and according to recent works reasonably good results have been achieved by using a histochemical marker such as cytokeratine 19 and the so-called 'up to seven criteria' to divide patients into categories according to their risk of relapse. In addition to liver transplantation other therapies have been proposed such as resection, tumor ablation by different means, embolization and chemotherapy. An important step in the treatment of advanced HCC has been the introduction of sorafenib, the first oral, systemic drug that has provided significant improvement in survival. Treatment of HCC patients must be multidisciplinary and by using the different approaches discussed in this review it is possible to offer prolonged survival and quite good and sometimes even excellent quality of life to many patients. | Roberto Mazzanti Umberto Arena Renato Tassi | 2016 | World Journal of Experimental Medicine2016，6，1： | 10 |
| 2 | Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome显示文摘 | Laura Zanotti Eliana Bignotti Stefano Calza Elisabetta Bandiera Giuseppina Ruggeri Claudio Galli Germana Tognon Monica Ragnoli Chiara Romani Renata A. Tassi Luigi Caimi Franco E. Odicino Enrico Sartori Sergio Pecorelli Antonella Ravaggi | 2012 | Clinical Chemistry and Laboratory Medicine2012，，12： | 2 |
| 3 | Prenatal diagnosis of congenital human cytomegalovirus infection 显示文摘 | Nicolini U Kustermann A Tassis B | 1994 | Prenat Diagn1994，14，10： | 2 |
| 4 | Best approach for prostate cancer detection: a prospective study on transperineal versus transrectal six-core prostate biopsy显示文摘 | P Emiliozzi A Corsetti B Tassi G Federico M Martini V Pansadoro | 2003 | Urology2003，，： | 2 |
| 5 | Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes 显示文摘 | Tassi L Colombo N Cossu M | 2005 | Brain2005，128，2： | 1 |
| 6 | Intraperitoneal normalsaline in fusion forpost operative pain after laparoscopic cholecystectomy显示文摘 | Tsimoyiannis E C Siakas P Tassis A | 1998 | World J Surg1998，22，8： | 1 |
| 7 | Reduced plasma fibrinolytic potential in patients with recurrent implanta- tion failure after IVF and embryo transfer 显示文摘 | Mart nez-Zamora MA Creus M Tassies D | 2011 | Hum Reprod2011，26，3： | 1 |
| 8 | Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cells显示文摘 | Maier T Tun-Kyi A Tassis A | 2003 | Blood2003，102，7： | 1 |
| 9 | Reduced plasma fibrinolytic potential in patients with recurrent implantation failure after IVF and embryo transfer显示文摘 | Martínez-Zamora MA Creus M Tassies D | 2011 | Hum Reprod2011，26，： | 1 |
| 10 | Clinical presentation and pathogenesis of cold-induced autoinfammatory disease in a family with recurrence of an NLRP12 mutation显示文摘 | Borghini S Tassi S Chiesa S | 2011 | Arthritis Rheum2011，63，： | 1 |
| 11 | Chemical composition of fumarolic gases and spring discharges from EI Chichon volcano,Mexico:Causes and implications of the changes detected over the period 1998-2000显示文摘 | Tassi F vaselli O Capaccioni B Macias J Ⅰ Nencetti A | 2003 | Journal of Volcanology and Geothermal Resesrch2003，，123： | 1 |
| 12 | Prevalence of thrombophilia in women with severe ovarian hyperstimulation syndrome and cost-effectiveness of screening显示文摘 | Fabregues F Tassies D Reverter J C | 2004 | Fertil Steril2004，8，4： | 1 |
| 13 | Creatine kinase isoenzymes inhuman trichinellosis显示文摘 | Tassi C Materazzi J Pozio E | 1995 | Clin Chim Acta1995，239，2： | 1 |
| 14 | Intraperitoneal normal saline infusion for postoperative pain after laparoscopic cholecystectomy显示文摘 | Tsimoyiannis EC Snakes P Tassis A | 1998 | World J Surg1998，22，： | 1 |
| 15 | Enhancement of fibro-blast growth factor(FGF)activity by an FGF-binding pro-tein显示文摘 | Tassi E Al-Attar A Aigner A | | 0，，43： | 1 |
| 16 | Aquaporin 4 expression incontrol and epileptic human cerebral cortex显示文摘 | Medici V Frassoni C Tassi L | 2011 | Brain Res2011，1367，： | 1 |
| 17 | Minithoracoscopy:a complementary technique for medical thoracoscopy显示文摘 | Tassi GF Marchetti GP Pinelli V | 2011 | Respiration2011，82，2： | 1 |
| 18 | Claudin-7 expres- sion in human epithelial ovarian cancer 显示文摘 | Tassi RA Bignotti E Falchetti M | 2008 | Int J Gynecol Cancer2008，18，6： | 1 |
| 19 | Phytoremediation treatability test for an industrial site contaminated by Pb, Zn and As显示文摘 | Barbafieri M Tassi E Rizzi L | 2004 | Soil and Sediment Contamination2004，13，2： | 1 |
| 20 | The effects of exogenous plant growth regulators in the phytoextraction of heavy metals显示文摘 | Tassi E Pouget J Petruzzelli G | 2008 | Chemosphere2008，71，1： | 1 |
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