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| 1 | Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome based on NMR techniques显示文摘Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome has been performed by comparison with those of normal rats based on NMR techniques. The relative contents of formate,creatinine,2-oxoglutarate(2-OG) ,citrate,taurine,trimethylamine-N-oxide(TMAO) ,succinate and hippurate in the urine of the rats with Qi deficiency and blood stasis syndrome have been changed. These results have provided evidence for understanding the mechanism and the therapy of Qi defi-ciency and blood stasis syndrome. | LI Lin WANG JianNong REN JianXun XIANG JunFeng TANG YaLin LIU JianXun HANDing | 2007 | Chinese Science Bulletin2007，52，22： | 21 |
| 2 | Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway显示文摘 | Bo Bai Jiyou Tang Haiqing Liu Jing Chen Yalin Li Wengang Song | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 14 |
| 3 | Geochemical Characteristics,Genesis of Concealed Cu-rich Ore Body in the Jinchuan Deposit,Northwestern China,and Its Prospecting显示文摘The Jinchuan deposit is hosted by the olivine-rich ultramafic rock body, which is the third-largest magmatic sulfide Ni-Cu deposit in the world currently being exploited. Seeking new relaying resources in the deep and the border of the deposit becomes more and more important. The ore body, ore and geochemistry characteristics of the concealed Cu-rich ore body are researched. Through spatial analysis and comparison with the neighboring Ⅱ1 main ore body, the mineralization rule of the concealed Cu-rich ore body is summed up. It is also implied that Cu-rich magma may exist between Ni-rich magma and ore pulp during liquation differentiation in deep-stage chambers, which derives from deep-mantle Hi-MgO basalt magma. It is concluded that the type of ore body has features of both magmatic liquation and late reconstruction action. It has experienced three stages: deep liquation and pulsatory injection of the Cu- and PPGE-rich magma, concentration of tectonic activation, and the later magma hydrothermal superimposition. In addition, the Pb and S isotopes indicate the magma of I6 concealed Cu-rich ore body originates predominantly from mantle; however, it is interfused by minute crust material. Finally, it is inferred that the genesis of the Cu-Ni sulfide deposit is complex and diverse, and the prospect of seeking new deep ore bodies within similar deposits is promising, especially Cu-rich ore bodies. | GAO Yalin TANG Zhongli ZHANG Mingjie TIAN Yulong XIAO Lizhong | 2009 | Acta Geologica Sinica(English Edition)2009，83，6： | 9 |
| 4 | Insulating materials for realising carbon neutrality:Opportunities,remaining issues and challenges显示文摘The 2050 carbon-neutral vision spawns a novel energy structure revolution,and the construction of the future energy structure is based on equipment innovation.Insulating material,as the core of electrical power equipment and electrified transportation asset,faces unprecedented challenges and opportunities.The goal of carbon neutral and the urgent need for innovation in electric power equipment and electrification assets are first discussed.The engineering challenges constrained by the insulation system in future electric power equipment/devices and electrified transportation assets are investigated.Insulating materials,including intelligent insulating material,high thermal conductivity insulating material,high energy storage density insulating material,extreme environment resistant insulating material,and environmental-friendly insulating material,are cat-egorised with their scientific issues,opportunities and challenges under the goal of carbon neutrality being discussed.In the context of carbon neutrality,not only improves the understanding of the insulation problems from a macro level,that is,electrical power equipment and electrified transportation asset,but also offers opportunities,remaining issues and challenges from the insulating material level.It is hoped that this paper en-visions the challenges regarding design and reliability of insulations in electrical equipment and electric vehicles in the context of policies towards carbon neutrality rules.The authors also hope that this paper can be helpful in future development and research of novel insulating materials,which promote the realisation of the carbon-neutral vision. | Chuanyang Li Yang Yang Guoqiang Xu Yao Zhou Mengshuo Jia Shaolong Zhong Yu Gao Chanyeop Park Qiang Liu Yalin Wang Shakeel Akram Xiaoliang Zeng Yi Li Fangwei Liang Bin Cui Junpeng Fang Lingling Tang Yulin Zeng Xingtao Hu Jiachen Gao Giovanni Mazzanti Jinliang He Jianxiao Wang Davide Fabiani Gilbert Teyssedre Yang Cao Feipeng Wang Yunlong Zi | 2022 | High Voltage2022，7，4： | 4 |
| 5 | Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis显示文摘Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. | Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 3 |
| 6 | Author correction to'Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TL R4 signaling’[Acta Pharmaceutica Sinica B 12(2022)1198-1212]显示文摘The authors regret that there were some errors or inexact de-scriptions in author afiliation,the section of materials and methods,and the figure caption of Fig.2A owing to the negligence of authors when writing the manuscript,and there was a picture error in Fig.10 and graphical abstract figure owing to the inappropriate selection for the picture of Radix Ophiopogon japonicus.In author afiliation,'Department of Pharmacology of Chinese Material Medica'should be corrected to'Department of Pharmacology of Chinese Materia Medica'.In 2.4. | Yunhao Wu Xiu Yu Yuwei Wang Yalin Huang Jiahui Tang Shuaishuai Gong Siyu Jiang Yuanli Xia Fang Li Boyang Yu Yuanyuan Zhang Junping Kou | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 3 |
| 7 | Helicobacter pylori infection is an infectious disease and the empiric therapy paradigm should be changed显示文摘Helicobacter pylori infection is an infectious disease.Given the alarmingly high antibiotic resistance in H.pylori,gastroenterologists should change the empiric H.pylori treatment paradigm to an antimicrobial susceptibility testing-guided precision treatment.Antimicrobial stewardship programs for H.pylori should be implemented locally,regionally,and nationally to monitor the antibiotic resistance pattern. | Hong Li Tiankuo Yang Hong Tang Xiaoqiong Tang Yalin Shen Mohammed Benghezal Alfred Tay Barry Marshall | 2019 | Precision Clinical Medicine2019，2，2： | 2 |
| 8 | Spectroscopic studies of the interaction between methyleneblue and G-quadruplex显示文摘G-rich single-stranded DNA (5′-TTAG-GG-3′) adopted a G-quadruplex structure in buffercontaining potassium ions. The spectroscopic featureand the interaction between methylene blue andG-quadruplex have been investigated by circular di-chroism, and nuclear magnetic resonance spectros-copy. The UV-Vis absorption and fluorescence spec-tral results show that the fluorescence behavior ofMB by single-stranded DNA fits Stern-Volmer staticquenching equation very well and they formed 1︰1complexes; dimeric G-quadruplexes were bound toMB with 1︰1 or 2︰1, and their equilibrium constantswere 1.047×105 and 8.79×104 L/mol, respectively.Based on the above results and 1H-NMR spectraldata, one may conclude that MB stacked either theterminal tetrads to form 1︰1 complexes or betweentwo terminal tetrads of G-quadruplexes to form 1︰2sandwich complexes with G-qudruplexes. | SUN Hongxia XIANG Junfeng ZHANG Yazhou XU Guangzhi XU Lianghua TANG Yalin | 2006 | Chinese Science Bulletin2006，51，14： | 2 |
| 9 | Green tea polysaccharide-conjugates protect human umbilical vein endothelial cells against impairments triggered by high glucose显示文摘 | Xiaoqiang Chen Yuefei Wang Yalin Wu Baoyu Han Yuejin Zhu Xiaolin Tang Qinglei Sun | 2011 | International Journal of Biological Macromolecules2011，，1： | 1 |
| 10 | Effects of NaCl on the J-aggregation of two thiacarbocyanine dyes in aqueous solutions显示文摘 | Junfeng Xiang Xiaorong Yang Ciping Chen Yalin Tang Wenpeng Yan Guangzhi Xu | 2003 | Journal of Colloid And Interface Science2003，，1： | 1 |
| 11 | Proton implantation induced photoluminescence enhancement in self - assembled InAs/GaAs quantum dots 显示文摘 | Yalin Ji Guibin Chen NaiYun Tang | 2003 | Appl Phys Lett2003，，82： | 1 |
| 12 | Nutrition impacts of non-solid cooking fuel adoption on under-five children in developing countries显示文摘This paper examines the nutrition impacts of using non-solid cooking fuel on under-five children in developing countries.We draw on data from more than 1.12 million children in 62 developing countries from the Demographic and Health Surveys(DHS).Results from both fixed effects(FE)and instrumental variable(IV)estimates show that using non-solid cooking fuel significantly improves the nutrition outcomes of under-five children.Compared with their peers from households mainly using solid fuel,children from households mainly using non-solid fuel exhibit a lower probability of experiencing stunting(by 5.9 percentage points)and being underweight(by 1.2 percentage points).Our further investigation provides evidence for several underlying mechanisms,such as improved indoor air quality,induced reduction in children’s respiratory symptoms,benefits on maternal health,and reduction in maternal time spent on fuel collection or cooking.Heterogenous analyses suggest that the nutrition benefits of using non-solid cooking fuel are more prominent among boys,children above three years old,and those from households of lower socioeconomic status,rural areas,and Southeast Asia. | Yalin Tang Yuhe Guo Gang Xie Chengfang Liu | 2024 | Journal of Integrative Agriculture2024，23，2： | 1 |
| 13 | Novel sintering behavior of polystyrene nano-latex particles in filming process显示文摘Filming process of polystyrene nano-latex (NPS) particles was studied by a combination of various methods. For a constant annealing time of 1 h, the AFM images showed that the deformation and sintering temperatures for NFS particles were ca. 90 ℃ and 100 ℃ respectively. In spin-lattice relaxation measurements of solid state NMR, it is found that TIL, T1S and /1L/I0 increased significantly after annealing at 90℃ and above. DSC results showed that there was an exothermic peak near Tg after annealing for 1 h at the selected temperatures below 95℃; otherwise, the exothermic peak disappeared after annealing at 100℃ or above. The apparent density of NPS increased suddenly in the temperature range. The results implied that the macromolecules in NPS particles are in a confined state with higher confor-mational energy and less cohensional interactions which are the drive force for the sintering at a lower temperature compared with the multichain PS particles and the bulk polymer. | Xiaozhong Qu Yalin Tang Liusheng Chen Xigao Jin | 2001 | Chinese Science Bulletin2001，46，12： | 0 |
| 14 | Ti3C2Tx MXene/carbon composites for advanced supercapacitors:Synthesis,progress,and perspectives显示文摘MXenes are a family of two-dimensional(2D)layered transition metal carbides/nitrides that show promising potential for energy storage applications due to their high-specific surface areas,excellent electron conductivity,good hydrophilicity,and tunable terminations.Among various types of MXenes,Ti3C2Tx is the most widely studied for use in capacitive energy storage applications,especially in supercapacitors(SCs).However,the stacking and oxidation of MXene sheets inevitably lead to a significant loss of electrochemically active sites.To overcome such challenges,carbon materials are frequently incorporated into MXenes to enhance their electrochemical properties.This review introduces the common strategies used for synthesizing Ti3C2Tx,followed by a comprehensive overview of recent developments in Ti3C2Tx/carbon composites as electrode materials for SCs.Ti3C2Tx/carbon composites are categorized based on the dimensions of carbons,including 0D carbon dots,1D carbon nanotubes and fibers,2D graphene,and 3D carbon materials(activated carbon,polymer-derived carbon,etc.).Finally,this review also provides a perspective on developing novel MXenes/carbon composites as electrodes for application in SCs. | Yanqing Cai Xinggang Chen Ying Xu Yalin Zhang Huijun Liu Hongjuan Zhang Jing Tang | 2024 | Carbon Energy2024，6，2： | 0 |
| 15 | Non-Flat Bisbenzylisoquinoline Alkaloid Fangchinoline As a Class of Potent G-Quadruplex Stabilizer with Anti-cancer Activity显示文摘混合物有选择地有约束力、稳定的 G 四倍的结构能禁止 telomerase 或击倒 -- 调整 oncogenes 并且可以充当反癌症药。有非扁平的结构的碱, fangchinoline,出现了强烈稳定分子间并且 intramolecular 平行搁浅了 G 四倍的结构,由 20 和 23 °C 的增加的融化的温度分别地。有约束力的模式被使用 NMR 和分子的建模方法调查。四条人的房间路线(HL-60, BGC-823, Bel-7402 和 KB ) 被采取测试 fangchinoline 的反增长效果, IC 50 价值从 16 ~ 32 µmol/L 被变化。这些结果证明 fangchinoline 或相关一半衍生物可以作为潜在的反癌症药代表指向 telomere 的代理人的一个班。 | Qian Li Junfeng Xiang Yalin Tang | 2015 | Chinese Journal of Chemistry2015，33，9： | 0 |
| 16 | Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4signaling显示文摘Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and contributes to the development of acute lung injury(ALI).Here we reported that ruscogenin(RUS),an effective steroidal sapogenin of Radix Ophiopogon japonicus,attenuated lipopolysaccharides(LPS)-induced pulmonary endothelial barrier disruption through mediating non-muscle myosin heavy chain IIA(NMMHC IIA)-Toll-like receptor 4(TLR4)interactions.By in vivo and in vitro experiments,we observed that RUS administration significantly ameliorated LPS-triggered pulmonary endothelial barrier dysfunction and ALI.Moreover,we identified that RUS directly targeted NMMHC IIA on its N-terminal and head domain by serial affinity chromatography,molecular docking,biolayer interferometry,and microscale thermophoresis analyses.Downregulation of endothelial NMMHC IIA expression in vivo and in vitro abolished the protective effect of RUS.It was also observed that NMMHC IIA was dissociated from TLR4 and then activating TLR4 downstream Src/vascular endothelial cadherin(VE-cadherin)signaling in pulmonary vascular endothelial cells after LPS treatment,which could be restored by RUS.Collectively,these findings provide pharmacological evidence showing that RUS attenuates LPS-induced pulmonary endothelial barrier dysfunction by inhibiting TLR4/Src/VE-cadherin pathway through targeting NMMHC IIA and mediating NMMHC IIA-TLR4 interactions. | Yunhao Wu Xiu Yu Yuwei Wang Yalin Huang Jiahui Tang Shuaishuai Gong Siyu Jiang Yuanli Xia Fang Li Boyang Yu Yuanyuan Zhang Junping Kou | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 0 |
| 17 | Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands显示文摘G-quadruplexes attract more and more attention in recent years.Numerous small molecules which can induce or stabilize the formation of G-quadruplexes have been investigated on the purpose of anticancer drug development.As a motif existed in physiological condition,flanking sequences are an important part of G-quadruplexes but the study on the impact of flanking sequences on (G-quadruplex)-ligand binding is rarely reported.In this paper,the effects of flanking sequences on binding affinity between a series of unimolecular parallel-stranded G-quadruplex sequences derived from c-myc oncogene promoter (termed as c-myc G-quadruplexes) and their ligands are discussed in detail.The results showed that the flanking sequences on c-myc G-quadruplexes play key roles in (G-quadruplex)-ligand interaction.When a c-myc G-quadruplex is bound to its ligands,the flanking sequences might form a binding cavity above the terminal G-quartet,which could provide a suitable site for ligands to dock in.Moreover,the bases on flanking sequences could interact with ligand through π-π stacking,and finally form a sandwich-stacking mode (terminal G-quartet,ligand and bases on the flanking sequence).This mode could stabilize the (G-quadruplex)-ligand complex effectively and enhance the binding affinity dramatically.However,flanking sequences are also found to exhibit steric hindrance effect which could impede the (G-quadruplex)-ligand binding. | GAI Wei YANG QianFan XIANG JunFeng SUN HongXia SHANG Qian LI Qian JIANG Wei GUAN AiJiao ZHANG Hong TANG YaLin XU GuangZhi | 2013 | Science China(Technological Sciences)2013，56，3： | 0 |
| 18 | Kinetic characterization of a slow chemical exchange between two sites in N,N-dimethylacetylamide by CEST NMR spectroscopy显示文摘Nuclear magnetic resonance(NMR)spectroscopy has provided many powerful tools for the study of dynamic processes.Among the reported methods,chemical exchange saturation transfer(CEST)is more suitable for systems with slow exchange rates,and there will be promising in the detection and dynamic mechanism of metastable substances.It has been widely used in magnetic resonance imaging(MRI),however whether it is applicable in the field of chemical kinetics needs more examples.Here we studied,as a proof of concept,the kinetics of the slow chemical exchange between the two N-methyl protons of N,N-dimethylacetylamide(DMA),exploiting QUantifying Exchange using Z-spectrum(QUEZS)and QUantifying Exchange using Saturation Time(QUEST)methods.It turned out that both of QUEZS and QUEST could give the corresponding exchange rates,showcasing the capability of this method to provide accurate kinetic data under a range of temperatures.Our results clearly demonstrated the reliability of CEST-based techniques as a tool for dynamic kinetics by NMR. | Lixia Wang Jikun Li Junfeng Xiang Jie Cui Yalin Tang | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 19 | A direct measurement method of quantum relaxation time显示文摘The quantum relaxation time of electrons in condensed matters is an important physical property,but its direct measurement has been elusive for a century.Here,we report a breakthrough that allows direct determination of quantum relaxation time at zero and non-zero frequencies using optical measurement.Through dielectric loss function,we connect bound electron effects to the physical parameters of plasma resonance and find an extra term of quantum relaxation time from inelastic scattering between bound electrons and conduction electrons at non-zero frequencies.We demonstrate here that the frequency-dependent inelastic polarization effect of bound electrons is the dominant contribution to quantum relaxation time of conduction electrons at optical frequencies,and the elastic polarization effect of bound electrons also dramatically changes the plasma resonance frequency through effective screening to charge carriers. | Peng Zhang Haoqi Tang Chuanchuan Gu Hong Wang Guangfu Luo Yalin Lu X.-D.Xiang | 2021 | National Science Review2021，8，4： | 0 |
| 20 | An important functional group, benzo[1,3]dioxole, of alkaloids induces the formation of the human telomeric DNA G-quadruplex显示文摘Over the past few decades, numerous molecules have been discovered or designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Some of these molecules have been developed as anticancer agents. To aid the design of anticancer agents, the ability of alkaloids possessing Protoberberine and Benzophenanthridine groups to induce the formation of G-quadruplexes were studied using CD spectroscopy. By careful examination of their structures, we found that a benzo[1,3]dioxole group plays an important role in influencing their inductive properties. The more functional groups the alkaloids have, the stronger their G-quadruplex inductive ability. | YANG Shu XIANG JunFeng YANG QianFan ZHOU QiuJu ZHANG XiuFeng Li Qian TANG YaLin XU GuangZhi | 2011 | Chinese Science Bulletin2011，56，7： | 0 |
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