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| 1 | Adjuvant treatment for triple-negative breast cancer: a retrospective study of immunotherapy with autologous cytokine-induced killer cells in 294 patients显示文摘Objective: To examine the efficacy and safety of a sequential combination of chemotherapy and autologous cytokine-induced killer(CIK) cell treatment in triple-negative breast cancer(TNBC) patients.Methods: A total of 294 post-surgery TNBC patients participated in the research from January 1, 2009 to January 1, 2015. After adjuvant chemotherapy, autologous CIK cells were introduced in 147 cases(CIK group), while adjuvant chemotherapy alone was used to treat the remaining 147 cases(control group). The major endpoints of the investigation were the disease-free survival(DFS) and overall survival(OS). Additionally, the side effects of the treatment were evaluated.Results: In the CIK group, the DFS and OS intervals of the patients were significantly longer than those of the control group(DFS:P = 0.047;OS: P = 0.007). The multivariate analysis demonstrated that the TNM(tumor-node-metastasis) stage and adjuvant CIK treatment were independent prognostic factors for both DFS [hazard ratio(HR)= 0.520, 95% confidence interval(CI):0.271-0.998, P = 0.049;HR = 1.449, 95% CI:1.118-1.877, P = 0.005, respectively] and OS(HR=0.414, 95% CI:0.190-0.903, P = 0.027;HR= 1.581, 95% CI:1.204-2.077, P = 0.001, respectively) in patients with TNBC. Additionally, longer DFS and OS intervals were associated with increased number of CIK treatment cycles(DFS: P = 0.020;OS: P = 0.040). The majority of the patients who benefitted from CIK cell therapy were relatively early-stage TNBC patients.Conclusion: Chemotherapy in combination with adjuvant CIK could be used to lower the relapse and metastasis rate, thus effectively extending the survival time of TNBC patients, especially those at early stages. | Yuhan Zhang Shuaibing Wang Beibei Yang Su Lu Yiyi Du Hong Liu | 2019 | Cancer Biology & Medicine2019，16，2： | 6 |
| 2 | Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis显示文摘Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. | Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 3 |
| 3 | Development and Application of an Extraction and Quantitative HPLC Method for Sulforaphene in Radish显示文摘Sulforaphene, an isothiocyanate generated by the conversion of glucoraphenin in radish(Raphanus sativus L.), plays an important role in plants as a defensive compound and has been shown to have anti-cancer properties. However, a reliable method for the determination of sulforaphene in radish has not yet been established. In the present study, the enzymolysis conditions, extraction solvent and extraction conditions employed to obtain sulforaphene from radish were all optimized using single factor experiments and orthogonal testing. During these trials, sulforaphene was separated and quantified using reverse phase C18 high performance liquid chromatography(HPLC), employing methanol︰water(3︰7 ν/ν) as the mobile phase at a flow rate of 0.3 mL · min-1 together with a detection wavelength of 245 nm. Evaluation of this newly established method showed good linearity between the sulforaphene concentration and the characteristic peak area over the range of 5 to 200 μg· m L-1(R2 = 0.9996). This method was thus found to be precise. It was established that sulforaphene was extracted from radish with 95.48% efficiency(RSD = 0.94%) using the optimized conditions. This same technique was successfully applied to the quantification of sulforaphene in the fleshy roots of different radish germplasms as a means of selecting the germplasms with the highest sulforaphene levels. | HUA Beibei WANG Haiping ZHAO Wen QIU Yang LIU Su LI Xixiang | 2015 | Horticultural Plant Journal2015，1，2： | 2 |
| 4 | NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry显示文摘Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread.Therefore,the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial.Using a library of compounds targeting host lipid metabolic factors and testing them for their ability to block pseudorabies virus(PRV)and vesicular stomatitis virus(VSV)infection,we found that U18666A,a specific inhibitor of Niemann-Pick C1(NPC1),is highly potent in suppressing the entry of diverse viruses including pseudotyped severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).NPC1 deficiency markedly attenuates viral growth by decreasing cholesterol abundance in the plasma mem-brane,thereby inhibiting the dynamics of clathrin-coated pits(CCPs),which are indispensable for clathrin-mediated endocytosis.Significantly,exogenous cholesterol can complement the dynamics of CCPs,leading to efficient viral entry and infectivity.Administration of U18666A improves the survival and pathology of PRV-and influenza A virus-infected mice.Thus,our studies demonstrate a unique mechanism by which NPC1 inhibition achieves broad antiviral activity,indicating a potential new therapeutic strategy against SARS-CoV-2,as well as other emerging viruses. | Guoli Li Bingqian Su Pengfei Fu Yilin Bai Guangxu Ding Dahua Li Jiang Wang Guoyu Yang Beibei Chu | 2022 | Science China(Life Sciences)2022，65，2： | 1 |
| 5 | Effects of Shengmai Yin(生脉饮)on pulmonary and cardiac function in coronavirus disease 2019 convalescent patients with cardiopulmonary symptoms:a randomized,double blind,multicenter control trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Shengmai Yin(生脉饮,SMY)on visual analogue scale(VAS)for cardiopulmonary symptoms in coronavirus disease 2019(COVID-19)convalescent patients.METHODS:In this randomized,double blind and multicenter controlled trial,a total of 200 COVID-19 convalescent patients who with cardiopulmonary symptoms were enrolled from three medical centers in Hubei,China.These patients were randomized divided into trial group and the control group,100 patients in each one,SMY and its placebo were applied to respectively,for two weeks.VAS of clinical symptoms included shortness of breath,hidrosis,chest distress,palpitation,and dry cough was performed at 0,1,2 weeks.Decrease in VAS of 30%or more was defined as effective,and a reduction in VAS of 0 was defined as curative.RESULTS:A total of 192 completed the study.The VAS of TCM symptoms showed there was no difference in baseline between the two groups.The VAS in both groups was down-regulated,and there was no significant difference in VAS and cure rates at the first and second week between the two groups.There was no significant difference in breath,hidrosis,palpitation,and dry cough between the two groups but SMY treatment for two weeks has remarkable therapeutic effects in chest distress than placebo.CONCLUSIONS:SMY could effectively ameliorate the symptoms of chest distress,and improve the quality of life of the COVID-19 convalescent patients. | AN Xuedong MAO Lina XIA Ping SU Wen WANG Beibei KOU Leiya ZHANG Zequan QI Meng HU Song CHEN Jing LI Xiujuan LIU Jinwei ZHOU Juan QIAO Jie LUO Dan LUO Guangwei YAN Youqin YANG Guiping DONG Dandan ZHOU Wei TAO Junxiu JIN De TONG Xiaolin WEI Li | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 1 |
| 6 | Graphene oxide–silica composite coating hollow fiber solid phase microextraction online coupled with inductively coupled plasma mass spectrometry for the determination of trace heavy metals in environmental water samples显示文摘 | Shaowei Su Beibei Chen Man He Bin Hu | 2014 | Talanta2014，，： | 1 |
| 7 | Progress in the application of molecular imaging inpsychiatric disorders显示文摘Psychiatric disorders have always attracted a lot of attention from researchers due to the difficulties in their diagnoses and treatments.Molecular imaging,as an emerging technology,has played an important role in the researchers of various diseases.In recent years,molecular imaging techniques including magnetic resonance spectroscopy,nuclear medicine imaging,and fluorescence imaging have been widely used in the study of psychiatric disorders.This review will briefly summarize the progression of molecular imaging in psychiatric disorders. | Jia Tan Guangying Zhang Jiaqi Hao Huawei Cai Dingping Wu Zhuoxiao Su Beibei Liu Min Wu | 2023 | Psychoradiology2023，3，1： | 0 |
| 8 | Light-driven soft actuator based on graphene and WSe2 nanosheets composite for multimodal motion and remote manipulation显示文摘Remote controlled soft actuators have attracted ever-increasing interest in industrial,medical,robotics,and engineering fields.Soft actuators are charming than normal tools in executing dedicate tasks due to small volume and flexible body they have.However,it remains a challenge to design soft actuator that can adapt to multi-environments under remote stimuli with promising nano materials.Herein,we have developed a kind of near-infrared laser driven soft actuators with multi locomotive modes based on WSe2 and graphene nanosheets heterojunction.Different locomotion modes are driven by photothermal effect induced deformation to adapt to different working conditions.Moreover,the specially designed gripper driven by pulsed laser can lift a heavy load which is four times of its weight.This work broadens the choice of advanced nanomaterials for photothermal conversion of soft actuators.It is promising to realize applications including photothermal therapy and complex environment detection through the combination of the intelligent robot design and optical fiber system. | Zewen Su Yingjie Zhao Youqiang Huang Chaoyue Xu Xiaolei Yang Binrui Wang Beibei Xu Shiqing Xu Gongxun Bai | 2023 | Nano Research2023，16，1： | 0 |
| 9 | Future of targeted therapy for gastrointestinal cancer:Claudin 18.2显示文摘The treatment of gastrointestinal cancer has always been a crucial research area,and targeted therapy has been receiving increasing attention.At present,the effect of targeted therapy is unsatisfactory for gastric cancer.Thus,the discovery of new targets is crucial.Claudin 18.2(CLDN18.2),a member of the claudin family,belongs to the tight junction protein family that controls the flow of molecules between cell layers.CLDN18.2 expression has been discussed in many studies.In recent years,there have been many studies on targeted therapy with CLDN18.2-ideal monoclonal antibody 362.Furthermore,CLDN18.2-specific chimeric antigen receptor T therapy has been used for CLDN18.2-positive tumors,such as gastric and pancreatic cancers.Considerable research has been focused on CLDN18.2.CLDN18.2,a newly discovered marker for precise targeted therapy of gastric cancer,could offer new hope for the treatment of gastric cancer. | Qian Niu Jiamin Liu Xiaoxiao Luo Beibei Su Xianglin Yuan | 2021 | Oncology and Translational Medicine2021，7，3： | 0 |
| 10 | FOXK2激发广泛的转录抑制并阻遏缺氧反应和乳腺癌发生发展显示文摘临床上,严重智力障碍、West综合征、Dandy-Walker畸形和并指等临床表现与转录因子FOXK2功能障碍密切相关,然而目前FOXK2的具体生物学作用尚不明确。 | Lin Shan Xing Zhou Xinhua Liu Yue Wang Dongxue Su Yongqiang Hou Na Yu Chao Yang Beibei Liu Jie Gao Yang Duan Jianguo Yang Wanjin Li Jing Liang Luyang Sun Kexin Chen Chenghao Xuan Lei Shi Yan Wang 尚永丰 | 2017 | 科学新闻2017，19，4： | 0 |
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