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| 1 | Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations显示文摘AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD.METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing highperformance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP.RESULTS: NOD2/CARD15 mutations were found in 185patients (35.1%) and in 33 controls (16.5%, P<0.0001).SNP8/R702W (10.8% vs 6%, P = 0.02), SNP13/3020insC (19.4% vs 5%, P<0.0001) and exon4 R703C (2.1% vs 0%, P = 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vscontrols: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet = 1.71,95%CI = 1.12-2.6, P= 0.0001, ORtwo-riskalleles = 25.2,95%CI = 4.37- , P<0.0001), early disease onset (carrier:26.4 years vs non-carrier: 29.8 years, P = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08,P = 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55,P = 0.026) and increased need for resection (OR=1.71,95%CI: 1.13-2.62, P= 0.01), but not with duration, extraintestinal manifestations, familial disease or smoking. TLR4exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P= 0.06), in NOD2mut/wt: 26.7 years.CONCLUSION: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease,stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4mutation carriers tended to present at earlier age. | Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch Janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 2 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 3 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 4 | Interstitial cells of cajal generate electrical slow wave in the murine stomach显示文摘 | Tamas O Sean MW Kenton MS | | 0，，： | 1 |
| 5 | Remodeling of netwarks of interstitial cells of Cajal in a munine model of diabetic gastroparesis显示文摘 | Tamas O Ichiro T Wai KTC | 2000 | Diabetes2000，49，： | 1 |
| 6 | Efficacy and safety of statin therapy in children with familial hypercholesterlemia显示文摘 | Saskia DJ Leiv O Tamas S | 2004 | Circulation2004，292，3： | 1 |
| 7 | Efficacy and safety of statin therapy in children with familial hypercholesterlemia 显示文摘 | Saskia DJ Leiv O Tamas S | 2002 | Circulation2002，106，： | 1 |
| 8 | Hepatitis E Virus : identification of type-common epitopes 显示文摘 | Yarbough P O TamA W Fry K E | 1991 | J Virol1991，65，11： | 1 |
| 9 | Postinjury administration of pituitary adenylate cyclase activating polypeptide (PACAP) attenuates traumatically induced axonal injury in rats 显示文摘 | Tamas A Zsombok A Farkas O | 2006 | J Neurotrauma2006，23，5： | 1 |
| 10 | Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury 显示文摘 | Farkas O Tamas A Zsombok A | 2004 | Regul Pept2004，123，13： | 1 |
| 11 | Gastrointestinal stromal tumors:A clinicopathologic and immunohistochemical study of 136 cases显示文摘 | Zsolt O Tamas T Zoltan S | 2005 | Pathol Oncol Res2005，11，1： | 1 |
| 12 | Feed-in tariff and tradable green certificate in oligopoly 显示文摘 | Tamas M M Shrestha S O B Zhou Huizhong | 2010 | En- ergy Policy2010，38，8： | 1 |
| 13 | Comparison of open path and extractive long-path FTIR techniques in detection of air poltutants显示文摘 | ZOLTAN B VIKTORIA K TAMAS O | 2006 | Applied Spectroscopy Reviews2006，41，1： | 1 |
| 14 | Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves显示文摘 | Sean MW Tamas O Julia RB | 1999 | Gastroenterology1999，117，： | 1 |
| 15 | Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor显示文摘 | Zoltan O Tamas S Laszlo K Chris HR Douglas F Robert MC | 2001 | J Biol Chem2001，276，11： | 1 |
| 16 | A novel pacemarker mecha- nism drives gastrointestinal rhymicity显示文摘 | Sanders KM Tamas O Koh SD | 2000 | News Physiol Sci2000，15，： | 1 |
| 17 | Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury显示文摘 | Farkas O Tamas A Zsombok A | 2004 | Regul Pept2004，123，13： | 1 |
| 18 | Feed-in tariff and tradable green certificate in oligopoly显示文摘 | TAMAS M M SHRESTHA S O B ZHOU H Z | 2010 | Energy Policy2010，38，8： | 1 |
| 19 | Multi-electron transfer from heme-functionalized nanocr ystalline TiO2 to organohalide pollutants显示文摘 | Sherine O O Tamae I Gerald J M | 2006 | Am Chem Soc2006，128，： | 1 |
| 20 | Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia显示文摘 | Tamae K Kasai H | 2003 | Eur J Pharmacol2003，17，459： | 1 |
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