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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease显示文摘 | Moussa BHY Lana K Tamar A | 2014 | Parkinsonism Relat Disord2014，45，20： | 1 |
| 3 | Polymer-drug conjugates: progress in polymeric prodrugs 显示文摘 | KHANDARE J TAMAR A | 2006 | Prog Polym Sci2006，31，4： | 1 |
| 4 | Neurological mechanisms of green tea polyphenols inAlzheimer's and Parkinson's diseases显示文摘 | Orly W Silvia M Tamar A | 2004 | J Nutri Biochem2004，15，： | 1 |
| 5 | Role of T in Content in the Wetting of Cu and Au by T in-Bismuth Solders 显示文摘 | Tamar A Powers | 1994 | Journal of electronic Mat erials1994，23，8： | 1 |
| 6 | Origin of Defect-related Green Emission from ZnO Nanopar- ticles: Effect of Surface Modification 显示文摘 | Gong Y Y Tamar A Gertrude F N | 2007 | Nanoscale Res Lett2007，2，6： | 1 |
| 7 | Innovation, organization-al capabilities,and the bom - global firm 显示文摘 | Gary A Knight S Tamar Cavusgil | 2004 | Journal of In-ternational Business Studies2004，35，2： | 1 |
| 8 | Neurological mechanisms of green tea polyphenols in Alzheimers and Parekinsen's diseases显示文摘 | Silvia M Tamar A | 2004 | J Nutri Biechem2004，15，： | 1 |
| 9 | Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge显示文摘 | Jacob Korach A Ronit Machtinger A Tamar Perri A | 2009 | Acta Obstet et Gynecol2009，88，： | 1 |
| 10 | Skin respiration changes along the LPSC line 显示文摘 | Eory A Tamar K | 1986 | Agopuntura1986，4，1： | 1 |
| 11 | The E2 ubiquitin-conjugating enzymes Direct polyubiquitination to preferred lysines显示文摘 | Yael D Tamar Z Arie A | 2010 | J Biol Chem2010，285，： | 1 |
| 12 | Secretion of stem cell factor by alveolar fibroblasts in interstitial lung diseases显示文摘 | Elizabeth Fireman Shmuel Kivity Iris Shahar Tamar Reshef Yosef A Mekori | 1999 | Immunology Letters1999，，3： | 1 |
| 13 | Population-based drug-related anaphylaxis in children and adolescents captured by South Carolina Emergency Room Hospital Discharge Database(SCERHDD)(2000-2002)显示文摘 | SUZANNE L W AIMEE A D A TAMAR R K | 2007 | Pharm Drug Safety2007，16，2： | 1 |
| 14 | Neurological mechanisms of green tea polyphenols in Alzheimer's and Paekinson's diseases显示文摘 | Orly W Silvia M Tamar A | 2004 | J Nutr Biochem2004，15，： | 1 |
| 15 | Role of Tin Content in the Wetting of Cu and Au by Tin-Bismuth Solders显示文摘 | Tamar A Powers | 1994 | Journal of electronic Materials1994，23，8： | 1 |
| 16 | Neurological Mechanisms of Green Tea Polyphenols in Alzheimer's and Paekinson's Diseases显示文摘 | Silvia M Tamar A | 2004 | J Nutri Biochem2004，15，： | 1 |
| 17 | 2004 Space Almanac 显示文摘 | Tamar A Mehuron | 2004 | Air Force Magazine(S0730-6784)2004，87，8： | 1 |
| 18 | Neurological mechanisms of green teapolyphenols inAlzheimer's and Parkinson's diseases 显示文摘 | OrlyW Silvia M Tamar A | 2004 | J Nutri Bio2chem2004，15，50： | 1 |
| 19 | Modeling ionic hydmgels swelling: Characterization of the non - steady state 显示文摘 | Tamar Traitel Joseph Kost Smadar A Lapidot | 2003 | Biotechnol Bioeng2003，84，： | 1 |
| 20 | Programmable and autonomous computingmachine made of biomolecules 显示文摘 | Yaakov B Tamar P Rivka A | 2001 | Nature2001，414，22： | 1 |
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