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| 1 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 2 | A novel lightweightgypsum composite with diatomite and polypropylene fibers显示文摘 | Gencel O Coz Diaz del J J Sutcu M | 2016 | Construction and Building Materials2016，113，73： | 1 |
| 3 | The use of recycled paper processing residues in making porous brick with reduced thermal conductivity 显示文摘 | Sutcu M Akkurt S | 2009 | Ceramics international2009，35，7： | 1 |
| 4 | Atypical presentation of human bocavirus: Severe respiratory tract infection complicated with encephalopathy显示文摘 | Hacer Akturk Guntulu S?k Nuran Salman Murat Sutcu Burak Tatli Meral Akcay Ciblak Oguz Bulent Erol Selda Hancerli Torun Agop Citak Ayper Somer | 2015 | J. Med. Virol2015，，： | 1 |
| 5 | Effect of nicotine on hippocampal nicotinic acetylcholine alpha7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats显示文摘 | Delibas N Doguc DK Sutcu R | 2005 | Int J Neurosci2005，115，8： | 1 |
| 6 | Protecting Biometric Templates with Sketch:Theory and Practice显示文摘 | SUTCU Y QIMING L MEMON N | 2007 | lEEE Transactions on Information Forensics and Security2007，2，3： | 1 |
| 7 | Empathy: the Effectsof Undergraduate Nursing Education in Turkey显示文摘 | Ozcan C T Oflaz F Sutcu Cicek H | 2010 | Int NursRev2010，57，4： | 1 |
| 8 | Does melatonin protect or treat brain damage from traumatic oxidative stress显示文摘 | Kerman M Cirak B Ozguner MF Dagtekin A Sutcu R Altuntas I Delibas N | | 0，，： | 1 |
| 9 | Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with polycystic ovary syndrome显示文摘 | Oral B Mermi B Dilek M Alanoglu G Sutcu R | 2009 | Gynecol Endocrinol2009，25，： | 1 |
| 10 | ANN model for prediction of powder packing 显示文摘 | MUCAHIT Sutcu SEDAT Akkurt | 2007 | Journal of the European Ceramic Society2007，27，23： | 1 |
| 11 | Protecting biometric tem- plates with sketch : Theory and practice 显示文摘 | SUTCU Y LI Q MEMON N | 2007 | IEEE Trans- actions on Information Forensics Security2007，2，3： | 1 |
| 12 | Characterization and combustion kinetics of chars obtained from loquat stones显示文摘 | SUTCU H PISKIN S | | 0，，02： | 1 |
| 13 | Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow显示文摘 | Habil Yucel Mehmet Ozaydin Abdullah Dogan Dogan Erdogan Yasin Turker Betul Mermi Ceyhan Recep Sutcu | 2012 | Scandinavian Journal of Clinical & Laboratory Inv2012，，6： | 1 |
| 14 | Serum C-reactive protein and interleukin6 levels in neonatal sepsis显示文摘 | Icagasioglu D Caksen H Sutcu I | 2002 | Acta Med (Hradec Kralove)2002，45，3： | 1 |
| 15 | Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats 显示文摘 | GULTEKIN F KARAKOYUN I SUTCU R | 2007 | Int J Neurosci2007，117，1： | 1 |
| 16 | Protecting biometric templates with sketch: Theory and practice显示文摘 | SUTCU Y QIMING L MEMON N | 2007 | IEEE Transactions on Information Forensics and Security2007，2，3： | 1 |
| 17 | Gingival crevicular fluid leptin levels in periodontitis patients with long-term and heavy smoking 显示文摘 | Bozkurt F Y Yetkin A Z Sutcu R | 2006 | J Periodontol2006，77，4： | 1 |
| 18 | Serum C-reactive protein and interleukin6 levels in neonatal sepsis显示文摘 | Icagasioglu D Caksen H Sutcu I | 2002 | Acta Medica (Hradec Kralove)2002，45，3： | 1 |
| 19 | Influence of crystallographic orientation on hydration of MgO single crystals显示文摘 | Mucahit Sutcu Sedat Akkurt Salih Okur | 2009 | Ceram Int2009，35，： | 1 |
| 20 | Gingival crevicular fluid leptin levels in periodontitis patients with long- term and heavy smoking显示文摘 | BOZKURT F Y YETKIN AY Z SUTCU R et 01 | 2006 | Journal of Periodontology2006，77，4： | 1 |
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