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| 1 | Risk factors and clinical responses of pneumonia patients with colistin-resistant Acinetobacter baumannii-calcoaceticus显示文摘BACKGROUND Nosocomial infections with carbapenem-resistant Acinetobacter baumanniicalcoaceticus complex(ABC)strains are great problem for intensive care units.ABC strains can develop resistance to all the antibiotics available.Carbapenem resistance is common and colistin resistance is rare in our country.Knowing the risk factors for colistin resistance is important since colistin seems to be the only remaining therapeutic option for the patients with pneumonia due to extensively drug resistant ABC for our country.AIM To investigate the comparison of clinical responses and outcomes between pneumonia patients with colistin-susceptible and-resistant Acinetobacter sp.Strains.METHODS During the study period,108 patients with pneumonia due to colistin-susceptible strains and 16 patients with colistin-resistant strains were included retrospectively.Continuous variables were compared with the Mann-Whitney U test,and categorical variables were compared using Pearson’s chi-square test or Fisher’s Exact chi-square test for two groups.A binary logistic regression model was developed to identify the potential independent factors associated with colistin resistance in patients with colistin-resistant strains.RESULTS High Acute Physiology and Chronic Health Evaluation II scores(OR=1.9,95%CI:1.4-2.7;P<0.001)and prior receipt of teicoplanin(OR=8.1,95%CI:1.0-63.3;P=0.045)were found to be independent risk factors for infection with colistin-resistant Acinetobacter sp.Different combinations of antibiotics including colistin,meropenem,ampicillin/sulbactam,amikacin and trimethoprim/sulfamethoxazole were used for the treatment of patients with colistin-resistant strains.Although the median duration of microbiological cure(P<0.001)was longer in the colistin-resistant group,clinical(P=0.703),laboratory(P=0.277),radiological(P=0.551),microbiological response(P=1.000)and infection related mortality rates(P=0.603)did not differ between the two groups.Among the patients with infections due to colistin-resistant strains,seven were treated with antibiotic combinations that included sulbactam.Clinical(6/7)and microbiological(5/7)response rates were quite high in these patients.CONCLUSION The optimal therapy regimen is unclear for colistin-resistant Acinetobacter sp.infections.Although combinations with sulbactam seems to be more effective in our study patients,data supporting the usefulness of combinations with sulbactam is very limited. | Hande Aydemir Hande Idil Tuz Nihal Piskin Guven Celebi Canan Kulah Furuzan Kokturk | 2019 | World Journal of Clinical Cases2019，7，10： | 7 |
| 2 | In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells显示文摘电压门钠隧道(VGSC ) 活动提高与转移有关的房间行为,例如活动性,侵略,和 oncogene 表示。新生的选择拼接 Nav1.5 isoform 的形式在变形乳癌被表示。而且,异常槽口发信号小径能导致 oncogenesis 并且可以支持乳癌的前进。在这研究,我们试图分析 nNav1.5 禁止者 phenytoin 和槽口信号禁止者 N- 的效果[经由分别地发信号的 nNav1.5 VGSC 活动和槽口的抑制的三倍的否定乳癌房间线(MDA-MB-231 ) 上的 N-(3,5-difluorophenacetyl )-L-alanyl]-S-phenylglycine-t-butyl 酉旨(DAPT ) 。以便决定这些禁止者的单个、联合的效果, 4-[3-(4-iyodophenyl )-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1 ) 测试,创伤愈合试金,和 zymography 被执行检测增长,侧面的活动性,和矩阵 metalloproteinase-9 (MMP9 ) 活动分别地。metalloproteinases-1 (TIMP1 ) 的 nNav1.5, Notch4, MMP9,和织物禁止者的表情被量的即时反向的 transcriptasepolymerase 链反应也检测。当剂量比 10 眠獡 ? ┵高时, DAPT 引起了 antiproliferative 效果吗?? | Canan Cakir Aktas N. Dilara Zeybek A. Kevser Piskin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 2 |
| 3 | T cells in psoriatic lesional skin that survive conventional therapy with NB-UVB radiation display reduced IFN-gamma expression 显示文摘 | Piskin G Sylva-Steenland RM Bos JD | 2004 | Arch Dermatol Res2004，295，12： | 1 |
| 4 | Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers IL-12,IL-18 and IL-23显示文摘 | Piskin G Tursen U Sylva-Steenland RM | 2004 | Exp Dermatol2004，13，12： | 1 |
| 5 | Aneurysmal bone cyst recurrence in children: a review of 56 patients 显示文摘 | Basarir K Piskin A Gii91ii B | 2007 | J Pediatr Orthop2007，27，8： | 1 |
| 6 | Synthesis and characterization of MCM-41 with different methods and adsorption of Sr2+ on MCM-41 显示文摘 | Yilmaz M S Ozdemir O D Piskin S | 2015 | Research on Chemical Intermediates2015，41，1： | 1 |
| 7 | A profile and management of the US Army's underground storage tanks显示文摘 | Dharmavaram S Piskin K Hoctor T J | 1989 | Environ Manage1989，13，3： | 1 |
| 8 | Synthesis and Characterization of MCM-41 with Different Methods and Adsorption of Sr2+on MCM-41显示文摘 | Yilmaz M S Ozdemir O D Piskin S | 2015 | Research on Chemical Intermediates2015，41，1： | 1 |
| 9 | Serum lipid levels in pso-riasis显示文摘 | Piskin S Gurkok F Ekuklu G | 2003 | Yonsei Med J2003，44，1： | 1 |
| 10 | Observation of bacteria and fungi in infected root canals and dentinal tubules by SEM显示文摘 | Sen BH Piskin B Demirci T | | 0，，1： | 1 |
| 11 | 5-fluorouracil loaded chitosan microspheres for chemoembolization 显示文摘 | Denkbas E B Seyyal M Piskin E | 1999 | J Microencapsul1999，16，6： | 1 |
| 12 | Functional copolymers of N-isopropylacrylamide for bioengineering applications显示文摘 | Rzaev Z M O Dincer S Piskin E | | 0，，05： | 1 |
| 13 | Utilization of pyrite ash wastes by pelletization process 显示文摘 | Tugral N Derun E M Piskin M | 2007 | Powder Technology2007，176，2： | 1 |
| 14 | Platelet and mean platelet volume kinetics in adult patients with sepsis显示文摘 | Aydemir H Piskin N Akduman D | 2015 | Platelets2015，26，： | 1 |
| 15 | Treatment of intertrochanteric fractures in geriatric patients with a modified external fixator显示文摘 | Tomak Y Kocaoglu M Piskin A | 2005 | Injury2005，36，5： | 1 |
| 16 | Observation of bacteri- a and fungi in infected rootcanals and dentinal tubules by SEM显示文摘 | Sen B H Piskin B Demirci T | 1995 | Endod Dent Traumatol1995，11，1： | 1 |
| 17 | The effect of ultrasound on the healing of muscle-pedieulatod bone graft in spinal fusion显示文摘 | Aynaci O Under C Piskin A | 2002 | Spine2002，27，14： | 1 |
| 18 | The effect of different concentrations of EDTA on instrumented root canal walls 显示文摘 | SEN B H ERTURK O PISKIN B | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，108，4： | 1 |
| 19 | Increased concentration of soluble CD40 hgand in preeclampsia 显示文摘 | Alacacioglu I Ozcan MA Piskin O | 2007 | Clin Appl Thromb He- most2007，13，2： | 1 |
| 20 | T ceils in psoriatic le- sional skin that survive conventional therapy with NB-UVB radiation display reduced IFN gamma expression 显示文摘 | Piskin G Sylva-Steenland RM Bos JD | 2004 | Arch Dermatol Res2004，295，12： | 1 |
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