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| 1 | Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies显示文摘The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to HBV.Genome-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related traits.In this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver diseases.HBV persistence is associated with multiple genes with diverse roles in immune mechanisms.The strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to HBV.Associated variants affect both epitope binding specificities and expression levels of HLA molecules.Several other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs tolerance.HBV persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic bases.On the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV infections.The findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection. | Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil Gizem Dinler Doganay Levent Doganay | 2018 | World Journal of Gastroenterology2018，24，30： | 6 |
| 2 | Subfoveal choroidal thickness changes after intravitreal bevacizumab therapy for neovascular age-related macular degeneration显示文摘Dear Sir,Iam Dr.Cihanünlü,from the Department of Opthalmology,ümraniye Training and Research Hospital,Istanbul,Turkey.I write to present our study findings on subfoveal choroidal thickness(SFCT)changes after intravitreal bevacizumab(IVB)therapy for neovascular age-related macular degeneration(AMD).AMD is the leading cause of severe visual loss in adults older than 60y[1].Visual loss in late stages of AMD may be the result of one of the two processes:geographic atrophy(GA)or choroidal neovascularization(CNV).Many types | Cihan ünlü Gurkan Erdogan Betul Onal Gunay Betul Ilkay Sezgin Akcay Esra Kardes | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 3 |
| 3 | Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease显示文摘 | Ercan Varol Selahattin Akcay Mehmet Ozaydin Dogan Erdogan Abdullah Dogan Ahmet Altinbas | 2010 | Journal of Cardiology2010，，2： | 2 |
| 4 | Study of heavy metal pollution and speciation in Buyak Menderes and Gediz river sediments显示文摘 | H. Akcay A. Oguz C. Karapire | 2002 | Water Research2002，，4： | 2 |
| 5 | Carotid artery intima-media thickness correlates with intravascular ultrasound parameters in patients with slow coronary flow显示文摘 | Ahmet Camsari Turkay Ozcan Caner Ozer Burak Akcay | 2007 | Atherosclerosis2007，，2： | 2 |
| 6 | Effects of immunosuppressive drugs on serum lipid levels in renal transplant recipients 显示文摘 | Kanbay M Yildirir A Akcay A | 2006 | Transplant Proc2006，38，2： | 1 |
| 7 | Influence of obstructive sleep apnea on left ventricular mass and global function:sleep apnea and myocardial performance index 显示文摘 | Varol E Akcay S Ozaydin M | 2010 | Heart Vessel2010，25，5： | 1 |
| 8 | Cefpodoxime Proxetil-Related Hemolysis and Acute Interstitial Nephritis显示文摘 | Hakki Yilmaz Mukadder Ayse Bilgic Nuket Bavbek Ali Akcay | 2013 | Current Drug Safety2013，，2： | 1 |
| 9 | Study of heavy metal pollution and speciation in Buyak Menderes and Gediz river sediments显示文摘 | AKCAY H OGUZA A KARAP1RE C | 2003 | Water Research2003，37，4： | 1 |
| 10 | Iodine deficiency and goiter prevalence of the adult population in Erzurum显示文摘 | Akarsu E Akcay G Capoglu | 2005 | Endokrynopol2005，61，45： | 1 |
| 11 | Joint Dynamic Pricing of Multiple Perishable Products under Consumer Choice显示文摘 | Akcay Y H P Natarajan S H Xu | 2010 | Management Science2010，56，8： | 1 |
| 12 | Mean platelet volume in patients with prehypertension and hypertension显示文摘 | VAROL E AKCAY S ICLI A | 2010 | Clin Hemorhe- ol Microcirc2010，45，1： | 1 |
| 13 | Mean platelet volume in patients with coronary artery ectasia显示文摘 | Varol E Akcay S Ozaydin M | 2009 | Blood Coagul Fibrinolysis2009，20，5： | 1 |
| 14 | Effect of nitric oxide synthase inhibitor on experimentally induced burn wounds显示文摘 | Ozcan O Gundogdu C | 2000 | J Trauma2000，49，2： | 1 |
| 15 | The effect of melatonin on lipid peroxidation and nitrite/nitrate levels,and on superoxide dismutase and catalase activities in kainic acid-induced injury显示文摘 | Akcay YD Yalcin A Sozmen EY | 2005 | Cell Mol Biol Lett2005，10，2： | 1 |
| 16 | Addisonian crisis due to adrenal gland metastasis in Hodgkin's disease 显示文摘 | Akcay MN Tekin SB Akcay G | 2003 | 57 (9) :840 - 8412003，57，9： | 1 |
| 17 | Antioxidant activities of organic grape, pomace, juice, must, wine and their correlation with phenolic content显示文摘 | Yildirim H K Akcay Y D Guvenc U | 2005 | Int J Food Sci Technol2005，40，： | 1 |
| 18 | Panel reactive antibody positivity and associated HLA antibodies in Turkish renal transplant candidates显示文摘 | Ozdemir FN Sezer S Akcay A | 2004 | Transpl Immunol2004，12，2： | 1 |
| 19 | Study of heavy metal pollution and speciation in Buyak Menderes and Gediz river sediments显示文摘 | AKCAY H OGUZ A KARAPIRE C | 2003 | Water Research2003，37，4： | 1 |
| 20 | Phosphate-the silent stealthy cardiorenal culprit in all stages of chronic kidney disease: a systematic review 显示文摘 | Kanbay M Goldsmith D Akcay A | 2009 | Blood Purif2009，27，： | 1 |
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