|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 2 | Sensitive Detection of Cold Cesium Molecules Formed on Feshbach Resonances显示文摘 | CHIN C VULETIC V KERMAN A J | 2003 | Phys Rev Lett2003，90，03： | 1 |
| 3 | Clinical relevance of anti-HLA antibodies pre and post transplant显示文摘 | Kerman R H Orosz CG Lorber MI | 1997 | Am J Med Sci1997，313，： | 1 |
| 4 | Recent trends in electrochemical DNA biosensor technology 显示文摘 | Kerman K Kobayashi M Tamiya E | 2004 | Measurement Science and Technology2004，15，2： | 1 |
| 5 | High-Energy Backward Elastic Proton-Deuteron Scattering and Baryon Resonances显示文摘 | Kerman A K Kisslinger L S | 1969 | Phys Rev1969，180，： | 1 |
| 6 | Quantum dot-based immunosensor for the detection of prostate-specific antigen using fluorescence microscopy 显示文摘 | Kerman K Endo T Tsukamoto M | 2007 | Talanta2007，71，4： | 1 |
| 7 | Clinical Relevance of Anti-HLA Antibodies Pre and Post Transplant显示文摘 | Ronald H. Kerman Charles G. Orosz Marc I. Lorber | 1997 | The American Journal of the Medical Sciences1997，，5： | 1 |
| 8 | Seasonality of air-water fluxes of hexachlorocyclohexanes in Lake Ontario显示文摘 | Ridal J Kerman B Durham L | 1996 | Environ Sci Technol1996，30，3： | 1 |
| 9 | Biolubricant synthesis using immobilised lipase: Process optimisation of trimethylolpropane oleate production显示文摘 | Cecilia Orellana ?kerman Anna E.V. Hagstr?m M. Amin Mollaahmad Stefan Karlsson Rajni Hatti-Kaul | 2011 | Process Biochemistry2011，，12： | 1 |
| 10 | A geometric approach to low-rank matrix completion显示文摘 | Dai W Kerman E Milenkovic O | 2012 | IEEE Transactions on Information Theory2012，58，1： | 1 |
| 11 | Methylene Blue as a Novel Electrochemical Hybridization Indicator显示文摘 | Erdem A Kerman K Meric B | 2001 | Eleetroanal2001，13，3： | 1 |
| 12 | Human growth hor- mone ( hGH ) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective ret- rovirus vectors 显示文摘 | Archer J S Kerman W S Gould M N | 1994 | Proceedings of the National Academy of Sci- ences1994，91，： | 1 |
| 13 | Novel hybridization indicator methylene blue for the electrochemical detection of short DNA sequences related to the hepatitis B virus显示文摘 | Erdem A Kerman K Meric B | | 0，，： | 1 |
| 14 | IQ and ego-resiliency:conceptual and empirical connections and separatedness显示文摘 | Block J Kerman AM | | 0，，02： | 1 |
| 15 | Clinical relevance of anti-HLA antibodies pre and post transplantat显示文摘 | Kerman RH Orosz CG Lorber MI | 1997 | Am J Med Sci1997，313，5： | 1 |
| 16 | Quantum dot-based immunosensor for the detection of prostate-specific antigen using fluorescence microscopy显示文摘 | KERMAN K ENDO T TSUKAMOTO M | 2007 | Talanta2007，71，4： | 1 |
| 17 | Development of a novel hand-held formaldehyde gas sensor for the rapid detection of sick building syndrome显示文摘 | KAWAMURA K KERMAN K FUJIHARA M | 2005 | Sensors and Actuators B2005，105，： | 1 |
| 18 | Association between diabetes complications and leukocyte counts in Iranian patients显示文摘 | Moradi S Kerman SR Rohani F | 2012 | J Inflamm Res2012，5，： | 1 |
| 19 | Wind dependence of underwater ambient noise 显示文摘 | Kerman B R Evans D L Watts D R | 1983 | Boundary - Layer Meteorology1983，26，2： | 1 |
| 20 | Vestibular modulation leads to distinct hemodynamic patterning显示文摘 | Emanuel BA Yate BJ | 2000 | Am J Physiol Regulatory Integrative Comp Physiol2000，279，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员