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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | Reducing transfusion requirements in liver transplantation显示文摘Liver transplantation(LT) was historically associated with massive blood loss and transfusion. Over the past two decades transfusion requirements have reduced dramatically and increasingly transfusionfree transplantation is a reality. Both bleeding and transfusion are associated with adverse outcomes in LT. Minimising bleeding and reducing unnecessary transfusions are therefore key goals in the perioperative period. As the understanding of the causes of bleeding has evolved so too have techniques to minimize or reduce the impact of blood loss. Surgical 'piggyback' techniques, anaesthetic low central venous pressure and haemodilution strategies and the use of autologous cell salvage, point of care monitoring and targeted correction of coagulopathy, particularly through use of factor concentrates, have all contributed to declining reliance on allogenic blood products. Pre-emptive management of preoperative anaemia and adoption of more restrictive transfusion thresholds is increasingly common as patient blood management(PBM) gains momentum. Despite progress, increasing use of marginal grafts and transplantation of sicker recipients will continue to present new challenges in bleeding and transfusion management. Variation in practice across different centres and within the literature demonstrates the current lack of clear transfusion guidance. In this article we summarise the causes and predictors of bleeding and present the evidence for a variety of PBM strategies in LT. | Ciara I Donohue Susan V Mallett | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 3 | The constituent equation of piezoelectric bi- morphs显示文摘 | SMITS Jan G DALKE Susan I COONEY Thomas K | 1991 | Sensors and Actuator A1991，28，1： | 2 |
| 4 | Propranolol for the prevention of postoperative arrhythmias in general thoracic surgery显示文摘 | Charles D Bayliff David R Massel Richard I Inculet Richard A Malthaner Susan D Quinton Frank S Powell Renee S Kennedy | 1999 | The Annals of Thoracic Surgery1999，，1： | 2 |
| 5 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 6 | Photodamaging effects ofporphyrins and chitosan on primary human keratinocytes and car-cinoma cell cultures显示文摘 | Susan M Baldea I Senila S et a1 | 2011 | Int J Dermatol2011，50，3： | 1 |
| 7 | Speed-dependent body weight supported sit- to-stand training in chronic stroke: a case series 显示文摘 | Pierce B Susan I Kari D | 2011 | J Neurol Phys Ther2011，35，4： | 1 |
| 8 | A new approach to low-level image processing 显示文摘 | Smith S M Brady I M Susan | 1997 | International Journal of Computer Vision1997，23，1： | 1 |
| 9 | Near-Infrared Fluorescence Imaging as an Alternative to Bioluminescent Bacteria to Monitor Biomaterial-Associated Infections显示文摘 | Nina Dinjaski Suri Shalu Jaione Valle Susan M. Lehman I?igo Lasa María Auxiliadora Prieto Andrés J. García | 2014 | Acta Biomaterialia2014，，： | 1 |
| 10 | Random amplified polymorphic DNA (RAPD) markers for genetic analysis in Allium 显示文摘 | Susan E W Peter G I Robert J S | 1993 | Theor Appl Genet1993，86，： | 1 |
| 11 | The nu- tritive value of non-milk proteins for the preruminant calf: the effect of replacement of milk protein by soya-bean flour or fish-protein concentrate 显示文摘 | ROY J H B STOBO I J F SUSAN M | 1977 | The British Journal of Nutrition1977，38，： | 1 |
| 12 | Multi-destination trip patterns显示文摘 | Susan I Stewart | 1997 | Annals of Tourism Research1997，，2： | 1 |
| 13 | Comorbidity, Complications and Coding显示文摘 | Lisa I Lessoni Susan M Foley Jennifer Daley | 1992 | Bias Jama1992，，267： | 1 |
| 14 | Selec- tive activation of microglia in spinal cord but not higher conical regions following nerve injury in adult mouse 显示文摘 | ZHANG F X KUJUMON I V SUSAN S K | 2008 | Molecular Pain2008，，4： | 1 |
| 15 | Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases显示文摘 | Susan Pyne Kok-Choi Kong Peter I Darroch | 2004 | Seminars in Cell and Developmental Biology2004，，5： | 1 |
| 16 | Characterizing dynamic spatial and temporal residential density patterns from 1940 - 1990 across the North Central United States 显示文摘 | Roger B Hammer Susan I Stewart Richelle L Winkler | 2004 | Landscape and Urban Planning2004，69，： | 1 |
| 17 | Quantitative analysis of trace levels of geosmin and MIB in source and drinking water using headspace SPME 显示文摘 | Susan B W Brownlee B Trevor S I | 2000 | Wat Res2000，34，10： | 1 |
| 18 | Estimation Risk and Incentive Contracts for Portfolio Managers显示文摘 | | 1988 | Management Science1988，34，9： | 1 |
| 19 | Sugar and phytohormone response pathways: navigatinga signalling network 显示文摘 | Susan I Gibson | 2003 | Journal of Experimental Botany2003，55，395： | 1 |
| 20 | Osteoppntin deficiency protects joints against destruction in anti-type Ⅱ collagen antibodyinduced arthritis in mice显示文摘 | Kenji Y Muneaki I Susan RR | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
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