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| 1 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 2 | Research on sintering process of YSZ electrolyte显示文摘Yttria stabilized zirconia (YSZ) has widely been used as electrolyte in solid oxide fuel cell (SOFC). The microstructure of YSZ related to the fabrication process was discussed in the paper. With YSZ nano-powders about 40-100 nm as raw material, the YSZ adobe was manufactured by tape calendering process. The named three-step sintering process was performed at 1000 ℃ for 2 h, then raised the temperature with normal rate and as soon as up to 1400 ℃, the furnace was controlled at 1250-1300 ℃ for 10-20 h. The high dense YSZs with the relative density of 96%-99% were obtained; the grain size of YSZ could be reduced to 0.5-3 μm. The above result is benefited to co-fired in the electrode-supported SOFCs. | HAN Minfang TANG Xiuling PENG Suping | 2006 | Rare Metals2006，25，z2： | 7 |
| 3 | Chemiluminescence and electrochemiluminescence applications of metal nanoclusters显示文摘Due to strong photoluminescence,extraordinary photostability,excellent biocompatibility,and good water-solubility,metal nanoclusters have attracted enormous attention since discovered.They are found to be novel fluorescence labels for biological applications and environmental monitoring.Recently the chemiluminescence(CL) or electrochemiluminescence(ECL) of metal nanoclusters has received increasing attention.This review covers recent vibrant developments in this field of the past 5 years,and highlights different functions of metal nanoclusters in various CL and ECL systems,such as luminophores,catalysts,and quenchers.Latest synthetic methods of metal nanoclusters used in CL or ECL are also summarized.Furthermore,we discuss some perspectives and critical challenges of this field in the near future. | Shuang Han Zhichao Zhang Suping Li Liming Qi Guobao Xu | 2016 | Science China Chemistry2016，59，7： | 5 |
| 4 | H_2O/CO_2 co-electrolysis in solid oxide electrolysis cells显示文摘A solid oxide electrolysis cell(SOEC) is an environmental-friendly device which can convert electric energy into chemical energy with high efficiency. In this paper,the progress on structure and operational principle of an SOEC for co-electrolyzing H2O and CO2to generate syngas was reviewed. The recent development of high temperature H2O/CO2co-electrolysis from solid oxide single electrolysis cell was introduced. Also investigated was H2O/CO2co-electrolysis research using hydrogen electrode-supported nickel(Ni)-yttria-stabilized zirconia(YSZ)/YSZ/Sr-doped LaMnO3(LSM)-YSZ cells in our group. With 50 % H2O,15.6 % H2and 34.4 % CO2inlet gas to Ni- YSZ electrode,polarization curves(I- U curves) and electrochemical impedance spectra(EIS) were measured at 800 ℃ and 900 ℃. Long-term durability of electrolysis was carried out with the same inlet gas at 900 ℃ and 0.2 A/cm2. In addition,the improvement of structure and development of novel materials for increasing the electrolysis efficiency of SOECs were put forward as well. | Han Minfang Fan Hui Peng Suping | 2014 | Engineering Sciences2014，12，1： | 4 |
| 5 | Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles显示文摘Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to demineralization.There is an urgent need to develop new therapeutic materials with remineralization functions.This article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).PAMAM was excellent nucleation template,and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization.NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities.PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates,superior acidneutralization,and ions release.Therefore,the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone.PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions.Besides,the long-term remineralization capability of PAMAM+NACP was established.After prolonged fluid challenge,the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration.Furthermore,the hardness of predemineralized dentin was increased back to that of healthy dentin,indicating a complete remineralization.Therefore,the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization,hardness increase,and caries-inhibition capabilities. | Kunneng Liang Suping Wang Siying Tao Shimeng Xiao Han Zhou Ping Wang Lei Cheng Xuedong Zhou Michael D.Weir Thomas W.Oates Jiyao Li Hockin H.K.Xu | 2019 | International Journal of Oral Science2019，11，3： | 3 |
| 6 | Solid oxide fuel cell:materials,technology and application显示文摘Solid oxide fuel cells (SOFCs) offer a clean, pollution-free technology for the electrochemical conversion of chemical energy of hydrocarbon fuels into electricity. Many programs are being initiated in the United States, Europe, Japan and so on. The funding for SOFC development worldwide has risen dramatically and this trend is expected to continue for at least the next decades. These development programs are also investigating wider applications of SOFCs in stationary, residential, transportation and military sectors. Finally, it is summarized the key materials and fabrication processes of SOFC in this paper. | Han Minfang Liu Ze Zhou Su Peng Suping | 2010 | Engineering Sciences2010，8，1： | 1 |
| 7 | Molten Salt Derived Graphene-Like Carbon Nanosheets Wrapped SiO_(x)/Carbon Submicrospheres with Enhanced Lithium Storage显示文摘There is no doubt that SiO_(x) and carbon composite is one of the promising anode materials for lithium-ion batteries owing to its high capacity and rational cycling stability.Herein,we report a sol-gel synthesis followed by molten salt carbonization route to fabricate graphene-like carbon nanosheet wrapped SiO_(x)/C submicrospheres(SiO_(x)/C@2D-C).The in-situ generated carbon nanosheets under molten salt condition can further improve the electroconductivity,restrain the volumetric expansion and guarantee the structural integrity of the electrode.As a result,the as-obtained SiO_(x)/C@2D-C delivers a discharge capacity of 559 mAh·g^(-1) at 0.5 A·g^(-1) after 200 cycles and 548 mAh·g^(-1) at 1.0 A·g^(-1) even after 1000 cycles.The full cell assembled with SiO_(x)/C@2D-C as anode and commercial LiFeP0_(4) as cathode can achieve an energy density of 200 Wh·kg^(-1) and maintain a capacity of 66.7% after 100 cycles with a working potential of 2.8 V.The approach is simple and cost effective,which is promising for mass production of SiO_(x)-based materials for high energy LIBs. | Qianliang Zhang Suping Han Fang Tian Zhenyu Feng Baojuan Xi Shenglin Xiong Yitai Qian | 2021 | Chinese Journal of Chemistry2021，39，5： | 1 |
| 8 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 9 | The remedial effect of soluble interleukin-1 receptor type Ⅱ on endometriosis in the nude mouse model显示文摘Objective:Recent studies have shown that the local expression of soluble interleukin(IL)-1 receptor typeⅡ (sIL-1 RⅡ)in endometrial tissue of women with endometriosis is decreased,and the depression of IL-1 RⅡwas more significant in infertile women than that in fertile women with endometriosis.In this research,we investigated the remedial effect of sIL-1-RⅡadministration on endometriosis in the nude mouse model.Methods: Nineteen nude model mice with endometriosis were randomly divided into three groups:group A was treated by intraperitoneal administration with only sIL-1 RⅡfor two weeks,group B was similarly treated with only IL- 1,and group C(control)was administered saline.After 2 weeks,the size of the ectopic endometrial lesions was calculated,and the expression of vascular endothelial growth factor(VEGF)and B-cell lymphoma leukemia-2(Bcl- 2)were detected by immunohistochemistry.The IL-8 and VEGF levels in the peritoneal fluid(PF)and serum were also measured by enzyme-linked immunosorbent assay(ELISA).Results:The mean size of ectopic endometrial lesion did not differ between the three groups(P>0.05).Compared with the control,the expression of VEGF and Bcl-2 was significantly lower in group A,and higher in group B.In the three groups,the levels of IL-8 in the PF and serum were highest in group A,and lowest in group B.Conclusion:sIL-1 RⅡmay suppresse hyperplasia of ectopic endometriosis,perhaps by reducing the expression of certain cytokines,such as VEGF,IL-8,and Bcl-2, which could provide a new clinical strategy for the treatment of endometriosis. | Liying Gao Liang Sun Yugui Cui Zhen Hou Li Gao Jing Zhou Yundong Mao Suping Han Jiayin Liu | 2010 | The Journal of Biomedical Research2010，24，1： | 1 |
| 10 | Polymorphisms involved in the miR-218 - LAMB3 pathway and susceptibility of cervical cancer, a case–control study in Chinese women显示文摘 | Xiaoyi Zhou Xiaojun Chen Lingmin Hu Suping Han Fulin Qiang Yuling Wu Li Pan Hongbing Shen Ying Li Zhibin Hu | 2010 | Gynecologic Oncology2010，，2： | 1 |
| 11 | Impact of the Pacific–Japan Teleconnection Pattern on July Sea Fog over the Northwestern Pacific: Interannual Variations and Global Warming Effect显示文摘The northwestern Pacific(NWP) is a fog-prone area, especially the ocean east of the Kuril Islands. The present study analyzes how the Pacific–Japan(PJ) teleconnection pattern influences July sea fog in the fog-prone area using independent datasets. The covariation between the PJ index and sea fog frequency(SFF) index in July indicates a close correlation, with a coefficient of 0.62 exceeding the 99% confidence level. Composite analysis based on the PJ index, a case study, and model analysis based on GFDL-ESM2 M, show that in high PJ index years the convection over the east of the Philippines strengthens and then triggers a Rossby wave, which propagates northward to maintain an anticyclonic anomaly in the midlatitudes,indicating a northeastward shift of the NWP subtropical high. The anticyclonic anomaly facilitates the formation of relatively stable atmospheric stratification or even an inversion layer in the lower level of the troposphere, and strengthens the horizontal southerly moisture transportation from the tropical–subtropical oceans to the fog-prone area. On the other hand, a greater meridional SST gradient over the cold flank of the Kuroshio Extension, due to ocean downwelling, is produced by the anticyclonic wind stress anomaly. Both of these two aspects are favorable for the warm and humid air to cool, condense, and form fog droplets, when air masses cross the SST front. The opposite circumstances occur in low PJ index years, which are not conducive to the formation of sea fog. Finally, a multi-model ensemble mean projection reveals a prominent downward trend of the PJ index after the 2030 s, implying a possible decline of the SFF in this period. | Jingchao LONG Suping ZHANG Yang CHEN Jingwu LIU Geng HAN | 2016 | Advances in Atmospheric Sciences2016，33，4： | 1 |
| 12 | A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants bytargeting the upstream region of spikeprotein HR2 motif显示文摘The continuous emergence of new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants meansthere is a need to explore additional strategies to develop broad-spectrum vaccines or therapeutics for individuals remaining at risk of coronavirus disease 2019(COVID-19).Neutralizing monoclonal antibody(mAb)that binds to theconserved S2 subunit of the SARS-CoV-2 spike(S)protein alone,or in combination with mAb that binds to the receptor-binding domain(RBD)of S protein,might be effective in eliciting protection from infection by a variety of SARS-CoV2 variants.Using high-throughput single-cell immunoglobulin sequencing of B cells from COVID-19-convalescent donors,we identified a high-affinity S2-specific mAb-39,that could inhibit original SARS-CoV-2 strain,Omicron BA.1,BA.2.86,BA.4,BA.5,and EG.5.1 S protein-mediated membrane fusion,leading to the neutralization of these pseudoviralinfections.Moreover,mAb-39 could also improve the neutralizing activity of anti-RBD antibody against the highlyneutralization-resistant Omicron variants.Molecular docking and point mutation analyses revealed that mAb-39 recognized epitopes within the conserved upstream region of the heptad repeat 2(HR2)motif of the S2 subunit.Collectively,these findings demonstrate that targeting the conserved upstream region of the HR2 motif(e.g.,using mAbs)provides anovel strategy for preventing the infection of SARS-CoV-2 and its variants. | Hang Su Jun Zhang Zhenfei Yi Sajid Khan Mian Peng Liang Ye Alan Bao Han Zhang Guangli Suo Qian Li Housheng Zheng Dandan Wu Thomas J.Kipps Lanfeng Wang Zhenghong Lin Suping Zhang | 2024 | hLife2024，2，3： | 0 |
| 13 | Histone lactylation promotes cell proliferation,migration and invasion through targeting HMGB1 in endometriosis显示文摘Endometriosis is defined as a condition with endometrium-like tissues migrating outside of the pelvic cavity.However,the mechanism of endometriosis is still unclear.Lactate can be covalently modified to lysine residues of histones and other proteins,which is called lactylation.The results showed that the higher level of lactate and lactate dehydrogenase A enhanced the histone H3 lysine 18 lactylation(H3K18lac)in ectopic endometrial tissues and ectopic endometrial stromal cells than that in normal endometrial tissues and normal endometrial stromal cells.Lactate promoted cell proliferation,migration,and invasion in endometriosis.Mechanistically,lactate induced H3K18lac to promote the expression of high-mobility group box 1(HMGB1)in endometriosis,and HMGB1 knockdown significantly reduced the cell proliferation,migration,and invasion of the lactate-treated cells through the phosphorylation of AKT.In conclusion,lactate could induce histone lactylation to promote endometriosis progression by upregulating the expression of HMGB1,which may provide a novel target for the prevention and treatment of endometriosis. | Jie Chen Pengfei Qin Yanli Sun Suping Han | 2023 | The Journal of Biomedical Research2023，37，6： | 0 |
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