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| 1 | Combined bone marrow stromal cells and oxiracetam treatments ameliorates acute cerebral ischemia/reperfusion injury through TRPC6显示文摘Ischemic stroke has become one of the leading causes of deaths and disabilities all over the world.In this study,we investigated the therapeutic effects of combined bone marrow stromal cells(BMSCs)and oxiracetam treatments on acute cerebral ischemia/reperfusion(I/R)injury.A rat model of middle cerebral artery occlusion(MCAO)followed by complete reperfusion,as well as a cortex neuron oxygen-glucose deprivation(OGD)model was established.When compared with BMSCs or oxiracetam monotherapy,combination therapy significantly improved functional restoration with decreased infarct volume in observed ischemic brain.We propose that it may occur through the transient receptor potential canonical(TRPC)6 neuron survival pathway.The increased expression of TRPC6 along with the reduction of neuronal cell death in the OGD cortex neurons and combination therapy group indicated that the TRPC6 neuron survival pathway plays an important role in the combined BMSCs and oxiracetam treatments.We further tested the activity of the calpain proteolytic system,and the results suggested that oxiracetam could protect the integrity of TRPC6 neuron survival pathway by inhibiting TRPC6 degradation.The protein levels of phospho-cAMP response element binding protein(p-CREB)were tested.It was found that BMSCs play a role in the activation of the TRPC6 pathway.Our study suggests that the TRPC6 neuron survival pathway plays a significant role in the protective effect of combined BMSCs and oxiracetam treatments on acute cerebral I/R injury.Combined therapy could inhibit the abnormal degradation of TRPC6 via decreasing the activity of calpain and increasing the activation of TRPC6 neuron survival pathway. | Jing Wang Ruohan Sun Zhenzhu Li Yujun Pan | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 17 |
| 2 | Correlation between lower gastrointestinal tract symptoms and quality of life in patients with stable chronic obstructive pulmonary disease显示文摘OBJECTIVE:To explore correlations between the symptoms of constipation and abdominal distention and severity of chronic obstructive pulmonary disease(COPD)in patients with stable disease.METHODS:We studied 191 patients with stable COPD(according to defined criteria)in this cross-sectional study from four three-level class A Chinese medicine hospitals in China.We built an Epidata 3.0 database and performed statistical analysis with SPSS,version 17.0.We analyzed correlations between the frequency of lower gastrointestinal tract symptoms(constipation and abdominal distention)and scores for major pulmonary symptoms(cough,sputum and wheezing)based on the St.George's Respiratory Questionnaire(SGRQ),6-minute walking distance(6MWD)and frequency of acute exacerbations of COPD(AECOPD).RESULTS:In addition to their pulmonary symptoms,39.79%and 40.31%of study patients withstable COPD reported constipation and abdominal distention,respectively.Scores for major pulmonary symptoms(cough,sputum and wheezing),AECOPD and SGRQ values in patients with constipation and abdominal distention were significantly greater,and the 6MWD markedly shorter,than in those without them.According to Pearson's correlation analysis,there were strong correlations between these lower gastrointestinal tract symptoms and scores for pulmonary symptoms,SGRQ,6MWD and AECOPD.CONCLUSION:Lower gastrointestinal tract symptoms such as constipation and abdominal distention can adversely affect pulmonary symptoms,frequency of acute exacerbations and quality of life in patients with stable COPD. | Yan Sun Fengjie Zheng Yuhang Li Ruohan Wu Yuchao Liu Miao Liu Jinchao Zhang Kuo Gao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 10 |
| 3 | A Fusion Steganographic Algorithm Based on Faster R-CNN显示文摘The aim of information hiding is to embed the secret message in a normal cover media such as image,video,voice or text,and then the secret message is transmitted through the transmission of the cover media.The secret message should not be damaged on the process of the cover media.In order to ensure the invisibility of secret message,complex texture objects should be chosen for embedding information.In this paper,an approach which corresponds multiple steganographic algorithms to complex texture objects was presented for hiding secret message.Firstly,complex texture regions are selected based on a kind of objects detection algorithm.Secondly,three different steganographic methods were used to hide secret message into the selected block region.Experimental results show that the approach enhances the security and robustness. | Ruohan Meng Steven G.Rice Jin Wang Xingming Sun | 2018 | Computers, Materials & Continua2018，，4： | 4 |
| 4 | Sugarcane bagasse dietary fiber as an adjuvant therapy for stable chronic obstructive pulmonary disease:a four-center,randomized,double-blind,placebo-controlled study显示文摘OBJECTIVE:To evaluate the efficacy and safety of sugarcane bagasse dietary fiber as an adjuvant therapy for improving quality of life in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a multicenter,randomized,double-blind,placebo-controlled trial.A total of196 participants were randomized into a trial group(treated with 6 g/day sugarcane bagasse plus conventional treatment,n = 98) and a control group(treated with placebo plus conventional treatment,n = 98).All efficacy analyses were performed according to the intention-to-treat(ITT) principle.A per-protocol analysis set(PPS) was used to analyze the cases that completed the clinical trial with good compliance.The trial period was 30 days,with a 6-month follow-up.Pre-and post-treatmentpulmonary symptom scores(cough,sputum,wheezing,and dyspnea) were recorded for both groups.The St.George's Respiratory Questionnaire(SGRQ) and the modified Medical Research Council(m MRC) dyspnea scale were assessed before treatment and at the end of the 6-month follow-up.RESULTS:The ITT population was 178 and the PPS population was 166.Post-treatment pulmonary clinical symptoms and severity of dyspnea(m MRC and SGRQ evaluation) were significantly improved in both the trial group and the control group(ITT and PPS:P < 0.05).However,there was no statistical difference between the two groups in post-treatment pulmonary symptoms and m MRC.There was a greater reduction in the SGRQ subscales of activity,effect and total score in the trial group compared with the control group(ITT and PPS:P < 0.01).There was no statistical difference in pre-and post-treatment safety variables in either group.CONCLUSION:Sugarcane bagasse combined with conventional treatment improved quality of life in patients with stable COPD.Sugarcane bagasse appears to be a safe herbal medicine with potential for treating patients with stable COPD when taken orally as an adjuvant therapy. | Liu Miao Zheng Fengjie Ni Lei Sun Yan Wu Ruohan Zhang Tianyu Zhang Jinchao Zhong Xianggen Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 2 |
| 5 | Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases显示文摘Mitochondria play a multidimensional role in the function and the vitality of the neurological system.From the generation of neural stem cells to the maintenance of neurons and their ultimate demise,mitochondria play a critical role in regulating our neural pathways'homeostasis,a task that is critical to our cognitive health and neurological well-being.Mitochondria provide energy via oxidative phosphorylation for the neurotransmission and generation of an action potential along the neuron's axon.This paper will first review and examine the molecular subtleties of the mitochondria's role in neurogenesis and neuron vitality,as well as outlining the impact of defective mitochondria in neural aging.The authors will then summarize neurodegenerative diseases related to either neurogenesis or homeostatic dysfunction.Because of the significant detriment neurodegenerative diseases have on the quality of life,it is essential to understand their etiology and ongoing molecular mechanics.The mitochondrial role in neurogenesis and neuron vitality is essential.Dissecting and understanding this organelle's role in the genesis and homeostasis of neurons should assist in finding pharmaceutical targets for neurodegenerative diseases. | Serra Ozgen Judith Krigman Ruohan Zhang Nuo Sun | 2022 | Neural Regeneration Research2022，17，4： | 2 |
| 6 | A multicenter randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of rhubarb in treating acute exacerbation of chronic obstructive pulmonary disease of the syndrome type phlegm-heat obstructing the lungs显示文摘Objective:To observe the clinical efficacy and safety of oral administration of the traditional Chinese herb rhubarb to treat acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:This was a multicenter randomized double-blinded placebo controlled study that took place in 7 provinces of China that enrolled 244 patients(aged 18e80 years)who had acute exacerbation of COPD with the traditional Chinese syndrome pattern of phlegm-heat obstructing lung.Participants were divided into experimental and control groups.The experimental group received 4.5 g of rhubarb granules twice daily and the control group received placebo granules.Both groups also received conventional Western therapy consisting of oxygen therapy,an antibiotic,expectorant,and a bronchodilator.Treatment lasted 10 days.Symptom scores for cough,sputum volume and color,wheezing and chest tightness before treatment and on days 3,5,7,and 10 during the treatment were recorded.Lung function,arterial blood gas and levels of serum inflammatory factors,interleukin-4(IL-4),interleukin-8(IL-8),and interleukin-10(IL-10)and tumor necrosis factor-alpha(TNF-a),before and after treatment were measured.Results:The sample size of the full analysis set(FAS)was 244 participants,and the sample size of per protocol set(PPS)was 235.Following 10 days’treatment,symptom scores of the experimental group were markedly lower than those of the placebo group(FAS:mean difference1.67,95%CI:e2.66 to0.69,P Z 0.001;PPS:mean difference1.55,95%CI:2.56 to0.54,P Z 0.003).Lung function in the experimental group was significantly higher than in the placebo group(FEV1,FAS:mean difference 0.12,95%CI:0.06 to 0.18;P<0.001;PPS:mean difference 0.12,95%CI 0.05 to 0.18;P<0.001.FVC:FAS:mean difference 0.16,95%CI:0.06 to 0.26;P Z 0.002;PPS:mean difference 0.16,95%CI 0.05 to 0.26;P Z 0.003.FEV1%,FAS:mean difference 5.95,95%CI:3.36 to 8.53;P<0.001;PPS:mean difference 5.92,95%CI 3.28 to 8.56;P<0.001.).PaO2,PaCO2,as well as serum inflammatory factors were also improved when compared to the placebo group.There were no significant differences in the incidence rate of adverse reaction between the two groups.Conclusions:Compared with placebo,rhubarb granules significantly reduced symptom scores,improved blood oxygen level,controlled systemic inflammatory response,without significant adverse effects.Thus,rhubarb may be a beneficial adjuvant method for treating the phlegm-heat obstructing the lung syndrome pattern of AECOPD. | Fengjie Zheng Yan Sun Xianggen Zhong Yueqi Wang Ruohan Wu Miao Liu Yuchao Liu Kuo Gao Yuhang Li | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，2： | 1 |
| 7 | 佩德罗的“非洲梦”显示文摘中国公司投资建设的安哥拉库茵巴农场给当地经济发展注入支柱力量,让佩德罗等周边居民的生活产生了巨变。 | 刘贝 温利 Sun Ruohan | 2018 | 中国投资(中英文)2018，0，16： | 0 |
| 8 | IL-21 regulates macrophage activation in human monocytic THP-1-derived macrophages显示文摘Background:Interleukin-21(IL-21)has a regulatory effect on various immune cells.Its effect on macrophage function remains unclear.Aims:This study aimed to investigate the effect of IL-21 on the macrophagesmediated inflammatory response and explore its mechanism.Materials&Methods:Phorbol myristate acetate was used to induce THP-1-derived macrophages.Then,cells were stimulated with IL-21 and/or lipopolysaccharide(LPS).To determine the effect of IL-21 on the production of inflammatory factors in THP-1-derived macrophages,the messenger RNA(mRNA)and protein levels of IL-6,tumor necrosis factor-α(TNF-α),IL-8,and IL-10 were detected by real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA),respectively.Meanwhile,to explore the effect of IL-21 on macrophage polarization,macrophage phenotype,gene expression,and cytokine secretion mediated by THP-1-derived macrophage were detected by flow cytometry,RT-PCR,and ELISA.Results:First,we found that the IL-21 receptor was expressed in THP-1-derived macrophages.IL-21 enhanced LPS-mediated TNF-α,IL-6,and IL-10 production in THP-1-derived macrophages.During the polarization of THP-1-derived macrophages to M1-like macrophages,IL-21 induced the expression of macrophage surface markers CD86 and CD80,and related genes,such as TNF-α,IL-6,IL-1β,and DC-SIGN mRNA,inhibited Dectin-1 mRNA expression and promoted the secretion of TNF-α.During the polarization of THP-1-derived macrophages to M2-like macrophages,IL-21 enhanced the expression of macrophage surface markers CD86 and CD163,and related genes,such as TNF-α,IL-1β,IL-10,Dectin-1,and DC-SIGN mRNA,and promoted the secretion of IL-10.Conclusion:IL-21 promotes LPS-mediated production of inflammatory cytokines by THP-1-derived macrophages;IL-21 plays a two-way regulatory role in THP-1-derived macrophage polarization. | Leilei Jian Changhong Li Lin Sun Zhenzhen Ma Xinyu Wang Ruohan Yu Xiangyuan Liu Jinxia Zhao | 2021 | Rheumatology & Autoimmunity2021，1，1： | 0 |
| 9 | A Novel Steganography Scheme Combining Coverless Information Hiding and Steganography显示文摘At present,the coverless information hiding has been developed.However,due to the limited mapping relationship between secret information and feature selection,it is challenging to further enhance the hiding capacity of coverless information hiding.At the same time,the steganography algorithm based on object detection only hides secret information in foreground objects,which contribute to the steganography capacity is reduced.Since object recognition contains multiple objects and location,secret information can be mapped to object categories,the relationship of location and so on.Therefore,this paper proposes a new steganography algorithm based on object detection and relationship mapping,which integrates coverless information hiding and steganography.In this method,the coverless information hiding is realized by mapping the object type,color and secret information in object detection method.At the same time,the object detection method is used to find the safe area to hide secret messages.The proposed algorithm can not only improve the steganographic capacity of the two information hiding methods but also make the coverless information hiding more secure and robust. | Ruohan Meng Zhili Zhou Qi Cui Xingming Sun Chengsheng Yuan | 2019 | Journal of Information Hiding and Privacy Protection2019，1，1： | 0 |
| 10 | SRSFs mediate the function of AR in the ovarian granulosa cells of patients with PCOS显示文摘Ovarian hyperandrogenism is one of the characteristics of polycystic ovary syndrome(PCOS)and androgen receptor(AR)in ovarian granulosa cells(GCs)functions as an important element to the accumulation of androgens.This study verified the existence of alternative splicing variant of AR(AR-SVs)in the GCs of PCOS patients and found that the function of AR decreased significantly in the presence of AR-SVs.And compared to the normal individuals,the expression of Serine/arginine-rich splicing factor 2(SRSF2)was higher and the expression of SRSF3 was lower in the GCs of patients with AR-SVs.More importantly,we found that the expression of SRSF2 was inhibited and that the expression of AR was decreased after the successful upregulation of miRNA-183,and testostrone(T)concentrations in the culture medium were increased.The results also showed that the expression of SRSF3 decreased when miRNA-124 was successfully upregulated,while the expression of AR significantly increased;however,the function of AR was also inhibited when T concentration in the culture medium was increased.This study has proved that SRSFs are regulated by corresponding miRNAs,and the altered expression of SRSFs interferenced the alternative splicing process of AR and ultimately decreased the function of AR,leading to the accumulation of androgens in the ovary. | Jing Luo Hong Ye Lijuan Hao Yixuan Sun Ruohan Li Yanxi Li Zhu Yang | 2021 | Genes & Diseases2021，8，1： | 0 |
| 11 | A Novel Steganography Algorithm Based on Instance Segmentation显示文摘Information hiding tends to hide secret information in image area where is rich texture or high frequency,so as to transmit secret information to the recipient without affecting the visual quality of the image and arousing suspicion.We take advantage of the complexity of the object texture and consider that under certain circumstances,the object texture is more complex than the background of the image,so the foreground object is more suitable for steganography than the background.On the basis of instance segmentation,such as Mask R-CNN,the proposed method hides secret information into each object's region by using the masks of instance segmentation,thus realizing the information hiding of the foreground object without background.This method not only makes it more efficient for the receiver to extract information,but also proves to be more secure and robust by experiments. | Ruohan Meng Qi Cui Zhili Zhou Chengsheng Yuan Xingming Sun | 2020 | Computers, Materials & Continua2020，，4： | 0 |
| 12 | A Derivative Matrix-Based Covert Communication Method in Blockchain显示文摘The data in the blockchain cannot be tampered with and the users are anonymous,which enables the blockchain to be a natural carrier for covert communication.However,the existing methods of covert communication in blockchain suffer from the predefined channel structure,the capacity of a single transaction is not high,and the fixed transaction behaviors will lower the concealment of the communication channel.Therefore,this paper proposes a derivation matrix-based covert communication method in blockchain.It uses dual-key to derive two types of blockchain addresses and then constructs an address matrix by dividing addresses into multiple layers to make full use of the redundancy of addresses.Subsequently,to solve the problem of the lack of concealment caused by the fixed transaction behaviors,divide the rectangular matrix into square blocks with overlapping regions and then encrypt different blocks sequentially to make the transaction behaviors of the channel addresses match better with those of the real addresses.Further,the linear congruence algorithm is used to generate random sequence,which provides a random order for blocks encryption,and thus enhances the security of the encryption algorithm.Experimental results show that this method can effectively reduce the abnormal transaction behaviors of addresses while ensuring the channel transmission efficiency. | Xiang Zhang Xiaona Zhang Xiaorui Zhang Wei Sun Ruohan Meng Xingming Sun | 2023 | Computer Systems Science & Engineering2023，46，7： | 0 |
| 13 | LKAW: A Robust Watermarking Method Based on Large Kernel Convolution and Adaptive Weight Assignment显示文摘Robust watermarking requires finding invariant features under multiple attacks to ensure correct extraction.Deep learning has extremely powerful in extracting features,and watermarking algorithms based on deep learning have attracted widespread attention.Most existing methods use 3×3 small kernel convolution to extract image features and embed the watermarking.However,the effective perception fields for small kernel convolution are extremely confined,so the pixels that each watermarking can affect are restricted,thus limiting the performance of the watermarking.To address these problems,we propose a watermarking network based on large kernel convolution and adaptive weight assignment for loss functions.It uses large-kernel depth-wise convolution to extract features for learning large-scale image information and subsequently projects the watermarking into a highdimensional space by 1×1 convolution to achieve adaptability in the channel dimension.Subsequently,the modification of the embedded watermarking on the cover image is extended to more pixels.Because the magnitude and convergence rates of each loss function are different,an adaptive loss weight assignment strategy is proposed to make theweights participate in the network training together and adjust theweight dynamically.Further,a high-frequency wavelet loss is proposed,by which the watermarking is restricted to only the low-frequency wavelet sub-bands,thereby enhancing the robustness of watermarking against image compression.The experimental results show that the peak signal-to-noise ratio(PSNR)of the encoded image reaches 40.12,the structural similarity(SSIM)reaches 0.9721,and the watermarking has good robustness against various types of noise. | Xiaorui Zhang Rui Jiang Wei Sun Aiguo Song Xindong Wei Ruohan Meng | 2023 | Computers, Materials & Continua2023，，4： | 0 |
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