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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | The role and significance of Magnesium in modern day research-A review显示文摘Magnesium is one of the largely available elements in the earth’s crust. It has a low structural density with high specific strength. This unique material property has forced an increase in the use of magnesium and its alloys in various applications pertaining to industrial sector,automobiles, aerospace and biomedical. Since magnesium is a highly reactive metal, it is prone to higher rate of corrosion as compared to its counterparts. Thus, it is essential to analyze the corrosion behavior of magnesium and its alloys in its applications. An appropriate process is to be followed in the design and development of magnesium alloys which overcome the limitations of magnesium and enhance the desired material properties in accordance to their applications. This review paper summarizes the importance of magnesium and its material properties. The influence of various alloying elements on the mechanical properties of magnesium is reviewed. The broad classification of Mg alloys and their behavioral trends are detailed. The corrosion behavior of magnesium and the influence of corrosion products on the material characteristics of magnesium, in aqueous medium, are discussed. The manufacturing techniques of magnesium alloys along with the secondary techniques are also covered. The various applications and the limitations of magnesium in these applications are covered. A complete section is dedicated towards detailing the recent trends of magnesium(Mg) alloys, i.e., the biodegradable nature and applications of Mg alloys. The influence of biocorrosion on Mg alloys and techniques to overcome it have been deliberated. This paper provides a thorough review on recent developments of magnesium with respect to engineering applications. | S V Satya Prasad S B Prasad Kartikey Verma Raghvendra Kumar Mishra Vikas Kumar Subhash Singh | 2022 | Journal of Magnesium and Alloys2022，10，1： | 11 |
| 3 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 4 | Ameliorative effects of standardized extract from Trigonella foenum-graecum L.seeds on painful peripheral neuropathy in rats显示文摘Objective:To evaluate the effects of the standardized extract of fenugreek(Trigonella foenumgraecum L.Family:Leguminasae) seed(IND01) in animal models of peripheral neuropathy. Methods:IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound,trigonelline.The effects of daily oral administration of IND01(50,100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation(PSNL) and sciatic nerve crush injury(SNCI) during 30-days period.The measurements on thermal hyperalgesia(TH),motor function test(MFT) score and motor nerve conduction velocity (MNCV) were recorded.Results:IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards.Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL.Conclusions:IND01 was found to be effective in rat models of painful peripheral neuropathy. | Aashish S Morani Subhash L Bodhankar V Mohan Prasad A Thakurdesai | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，5： | 2 |
| 5 | The Impact of Environmental Uncertainty on the Market Orientation - Performance Relationship : A Study of the Hospital Industry显示文摘 | Subhash C Loniall P S Raju | 2001 | Journal of Economic and Social Research2001，3，1： | 1 |
| 6 | A two machine bicriteria scheduling problem显示文摘 | Subhash C S Hariharan R | 2000 | International Journal of Production Economics2000，65，： | 1 |
| 7 | Cost efficiency, economies of scale, technological progress and productivity in Indonesian banks显示文摘 | Margonoa H Subhash C S Paul D M I | 2010 | Journal of Asian Economics2010，21，1： | 1 |
| 8 | Cortisol promotes and integrates the osmotic competence of the organs in North African catfish (Clarias gariepinus Burchell): Evidence from in vivo and in situ approaches显示文摘 | Babitha G S Subhash P M C | 2010 | General and Comparative Endocrinology2010，168，1： | 1 |
| 9 | The risk-associated long non- coding RNA NBAT-1 controls neuroblastoma progression by regulat- ing cell proliferation and neuronal differentiation 显示文摘 | Pandey GK Mitra S Subhash S | 2014 | Cancer cell2014，26，5： | 1 |
| 10 | Corporate Board Size, Composition and Corporate Failures in Retailing Industry 显示文摘 | Rajeswarao S Chaganti Vijay Mahajan Subhash Hahma | 1985 | Journal of Management Studies1985，22，4： | 1 |
| 11 | Tcrpcnoid diversity in the leaf essential oils of Himalayan Lauraceae species显示文摘 | Subhash C J Rajendra C P Dinesh S B ct al | 2009 | Chemistry Biodiveritys2009，6，9： | 1 |
| 12 | An optimum design of the lining of amedium frequency induction melting furnace显示文摘 | Pritibhushan S Subhash S C | 1998 | International Trans-actions in Operational Research1998，5，4： | 1 |
| 13 | MEG3 long noncoding RNA regulates the TGF-15 pathway genes through formation of RNA-DNA triplex structures 显示文摘 | Mondal T Subhash S Vaid R | 2015 | Nat Commun2015，6，： | 1 |
| 14 | Potential use of mine tailings and fly ash in concrete 显示文摘 | Sunil B M Manjunatha L S Lolitha Ravi Subhash C Yaragal | 2015 | Advances in Concrete Construction2015，3，1： | 1 |
| 15 | A dynamic dam- age growth model for uniaxial compressive responseof rock aggregates显示文摘 | Huang C Y Subhash G Vitton S J | 2002 | Mechanics of Materials2002，34，5： | 1 |
| 16 | Catalytic tech- nology for carbon dioxide reforming of methane to synthe- sis gas 显示文摘 | FAN M S ZUHAIRI A A SUBHASH B | 2009 | Chem Cat Chem2009，1，2： | 1 |
| 17 | Experimental investigation of fabric-stress relations in granular materials显示文摘 | Subhash G Nemat-Nasser S Mehrabadi M M | 1991 | Mechanics of Materials1991，11，： | 1 |
| 18 | Polyamines and somatic embryngenesis in carrot Ⅲ effects of methylglyoxal bis (guanylhydrazone)显示文摘 | Subhash C Minnocha Nancy S | 1991 | Plant and Cell Physiol1991，32，3： | 1 |
| 19 | The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation 显示文摘 | Pandey GK Mitra S Subhash S | 2014 | Cancer Cell2014，26，5： | 1 |
| 20 | Polyamines and somatic embryogenesis in carrot Ⅲ effects of methylglyoxal bis(guanylhydrazone) 显示文摘 | Subhash C Minnocha Nancy S | 1991 | Plant and Cell Physiol1991，32，3： | 1 |
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