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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Petroleum Migration Direction of the Silurian Paleo-pools in the Tarim Basin, Northwest China显示文摘摘要:在这份报纸获得的结果显示 carbazole 类型混合物有高热的稳定性并且也在氧化和简历降级显示出稳定性。这种混合物仍然在分析干燥沥青样品有高集中和完全的分发,证明他们在学习 paleo 水池的石油移植是特别地有用的。在期间盆在在 Tarim 盆的 Tazhong 和 Tabei 区域的志留纪的油气体水池形成是第一阶段的(在志留纪时期的结束) 并且在 Awati 区域的秒阶段(在里面二叠) ,石油经历了长途的迁居。在志留纪的结束在在 Tazhong 的志留纪 paleo 水池的形成期间高举,石油主要在 Manjiaer 来自更低、中间的寒武纪的来源岩石下垂。石油向首先在 Tazhong 进入志留纪水库床的西南南方移居了。然后,它进一步沿着结构的带的高度从西北在志留纪以内移居了到东南到在 Tazhong 的志留纪 pinchout 边界的区域。在 Tabei 高举,在期间水池形成第一阶段,石油也从在 Manjiaer 的更低、中间的寒武纪的来源岩石下垂。它移植了西北进入在 Tabei 的志留纪水库床第一高举,然后迁居在志留纪水库以内在一样的方向继续,最后,石油在更高的位置被套住。在在志留纪的秒阶段水池形成期间,在在 Awati 附近的区域的床下垂,石油主要在 Awati 来自降低中间的寒武纪的来源岩石下垂。石油通过主要路径在 sag 附近在所有方向从产生中心移居了到志留纪水库,并且石油最后在更高的地点被套住。 | LIU Luofu ZHAO Yande HUO Hong CHEN Lixin CHEN Yuanzhuang ZHAO Suping LI Chao LI Shuangwen GUO Yongqiang LI Yan Key Lab for Hydrocarbon Accumulation Mechanism in the China University of Petroleum,Ministry of Education Basin and Reservoir Research Center, China University of Petroleum,Beijing 102249, China | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 12 |
| 3 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 4 | Effect of traffic restriction on atmospheric particle concentrations and their size distributions in urban Lanzhou, Northwestern China显示文摘During the 2012 Lanzhou International Marathon, the local government made a significant effort to improve traffic conditions and air quality by implementing traffic restriction measures. To evaluate the direct effect of these measures on urban air quality, especially particle concentrations and their size distributions, atmospheric particle size distributions(0.5–20 μm) obtained using an aerodynamic particle sizer(model 3321, TSI, USA) in June 2012 were analyzed. It was found that the particle number, surface area and volume concentrations for size range 0.5–10 μm were(15.0±2.1) cm-3,(11.8±2.6) μm2/cm3and(1.9±0.6) μm2/cm3, respectively, on the traffic-restricted day(Sunday), which is 63.2%, 53.0% and 47.2% lower than those on a normal Sunday. For number and surface area concentrations, the most affected size range was 0.5–0.7 and 0.5–0.8 μm, respectively, while for volume concentration, the most affected size ranges were 0.5–0.8, 1.7–2.0 and 5.0–5.4 μm. Number and volume concentrations of particles in size range 0.5–1.0 μm correlated well with the number of non-CNG(Compressed Natural Gas) powered vehicles, while their correlation with the number of CNG-powered vehicles was very low, suggesting that reasonable urban traffic controls along with vehicle technology improvements could play an important role in improving urban air quality. | Suping Zhao Ye Yu Na Liu Jianjun He Jinbei Chen | 2014 | Journal of Environmental Sciences2014，26，2： | 2 |
| 5 | Geochemistry of Permian Coal and Its Combustion Residues in Huainan Coalfield, China显示文摘INAA (instrumental neutron activation analysis) was used to determine the contents of trace elements in coal samples from 11 workable Permian coal seams in Huainan coalfield. With XRFS (X-ray fluorescence spectrometry), the geochemical composition of its combustion residues from Tianjiaan Power Plant and Luohe Power Plant was analyzed. In addition, the electron microprobe was employed to study the chemical composition of some fly ashes and bottom ashes. Compared with those of the coals around the world, most trace elements of the Huainan coal are characterized by a normal abundance. Like most coals worldwide, the elements Se, S, As, Sb, Br, U and Cl are enriched in Huainan coal according to dark’s value, while the other elements tend to be diluted. The large fluctuation in the contents of trace elements in this kind of coal demonstrates great differences in coal seams. On the other hand, the contents of these elements are very similar in different bottom and fly ash samples. The elements with low organic affinity tend to concentrate in fly and bottom ash than in coal, especially those elements associated with Fe. However, the elements with strong organic affinity tend to be volatile during the combustion. Moreover, the abundance of the elements in fly ash and bottom ash changes with different densities and with different particle sizes. The bottom and fly ashes consist of glass, lime, mullite, coal residues and ferrite minerals. Some residual chars contain higher contents of volatile elements, such as S, P, Cl and As, indicating that the ash containing more residual chars has a strong adsorption of some hazardous elements, suggesting a possible utilization of power plant ash in the field of water cleaning. | Huang Wenhui Yang Qi Department of Energy Resources and Geology , China University of Geosciences , Beijing 100083 Peng Suping Department of Geology and Engineering, China University of Mining and Technology, Beijing 100083 Zhao Zhigen Department of R | 2001 | Journal of China University of Geosciences2001，12，4： | 2 |
| 6 | From highly polluted inland city of China to'Lanzhou Blue':The air-pollution characteristics显示文摘Air quality was improved considerably and the so-called'Lanzhou Blue'appeared frequently in Lanzhou due to implementation of some strict emission-control measures in recent years.To better understand whether the concentration of each air pollutant had decreased significantly and then give some suggestions as to urban air-quality improvement in the near future,the variations of the Air Quality Index(AQI)and six criterion air pollutants(PM_(2.5),PM_(10),CO,SO_2,NO_2,and O_3)at five state-controlled monitoring sites of Lanzhou were studied from 2013 to 2016.The AQI,PM_(2.5),PM_(10),and SO_2 gradually decreased from 2013 to 2016,while CO and NO_2 concentrations had slightly increasing trends,especially in urban areas,due to the large number of motor vehicles,which had an annual growth rate of 30.87%.The variations of the air pollutants in the no-domestic-heating season were more significant than those in the domestic-heating season.The increase of ozone concentration for the domestic-heating season at a background station was the most significant among the five monitoring sites.The vehicle-exhaust and ozone pollution was increasingly severe with the rapid increase in the number of motor vehicles.The particulate-matter pollution became slight in the formerly highly polluted Lanzhou City.Some synergetic measures in urban and rural areas of Lanzhou should be taken by the local government in the near future to control fine particulate-matter(PM_(2.5))and ozone pollution. | SuPing Zhao Ye Yu DaHe Qin | 2018 | Research in Cold and Arid Regions2018，10，1： | 2 |
| 7 | Mechanism of Silurian Hydrocarbon Pool Formation in the Tarim Basin显示文摘There are three formation stages of Silurian hydrocarbon pools in the Tarim Basin. The widely distributed asphaltic sandstones in the Tazhong (central Tarim) and Tabei (northern Tarim) areas are the results of destruction of hydrocarbon pools formed in the first-stage,and the asphaltic sandstones around the Awati Sag were formed in the second-stage. The hydrocarbon migration characteristics reflected by the residual dry asphalts could represent the migration characteristics of hydrocarbons in the Silurian paleo-pools,while the present movable oil in the Silurian reservoirs is related to the later-stage (the third-stage) hydrocarbon accumulation. | Liu Luofu Chen Yuanzhuang Chen Lixin Pang Xiongqi Xie Qilai Huo Hong Zhao Suping Li Chao Li Shuangwen Guo Yongqiang Zhao Yande Li Yan | 2007 | Petroleum Science2007，4，4： | 2 |
| 8 | CRISPR-Cas adaptive immune systems in Sulfolobales:genetic studies and molecular mechanisms显示文摘CRISPR-Cas systems provide the small RNA-based adaptive immunity to defend against invasive genetic elements in archaea and bacteria.Organisms of Sulfolobales,an order of thermophilic acidophiles belonging to the Crenarchaeotal Phylum,usually contain both type I and typeⅢCRISPR-Cas systems.Two species,Saccharolobus solfataricus and Sulfolobus islandicus,have been important models for CRISPR study in archaea,and knowledge obtained from these studies has greatly expanded our understanding of molecular mechanisms of antiviral defense in all three steps:adaptation,expression and crRNA processing,and interference.Four subtypes of CRISPR-Cas systems are common in these organisms,including I-A,I-D,Ⅲ-B,andⅢ-D.These cas genes form functional modules,e.g.,all genes required for adaptation and for interference in the I-A immune system are clustered together to form aCas and i Cas modules.Genetic assays have been developed to study mechanisms of adaptation and interference by different CRISPR-Cas systems in these model archaea,and these methodologies are useful in demonstration of the protospacer-adjacent motif(PAM)-dependent DNA interference by I-A interference modules and multiple interference activities byⅢ-B Cmr systems.Ribonucleoprotein effector complexes have been isolated for SulfolobalesⅢ-B andⅢ-D systems,and their biochemical characterization has greatly enriched the knowledge of molecular mechanisms of these novel antiviral immune responses. | Zhenxiao Yu Suping Jiang Yuan Wang Xuhui Tian Pengpeng Zhao Jianan Xu Mingxia Feng Qunxin She | 2021 | Science China(Life Sciences)2021，64，5： | 2 |
| 9 | Abundances and distribution of minerals and elements in high-alumina coal fly ash from the Jungar Power Plant, Inner Mongolia, China显示文摘 | Shifeng Dai Lei Zhao Suping Peng Chen-Lin Chou Xibo Wang Yong Zhang Dan Li Yingying Sun | 2009 | International Journal of Coal Geology2009，，4： | 1 |
| 10 | Abundances and distribution of minerals and elements in high-alumina coal fly ash from the Jungar Power Plant, Inner Mongolia, China显示文摘 | Shifeng Dai Lei Zhao Suping Peng Chen-Lin Chou Xibo Wang Yong Zhang Dan Li Yingying Sun | 2009 | International Journal of Coal Geology2009，，4： | 1 |
| 11 | Antioxidant activity of lycopene extracted from tomato paste towards tfichloromethyl peroxyl radical CC13O2显示文摘 | ZHAO Yaping QIAN Suping YU Wenli | 2002 | Food Chemistry2002，77，2： | 1 |
| 12 | Understanding tissue-specificity with human tissue-specific regulatory networks显示文摘Tissue-specificity is important for the function of human body. However, it is still not clear how the functional diversity of different tissues is achieved. Here we construct gene regulatory networks in 13 human tissues by integrating large-scale transcription factor(TF)-gene regulations with gene and protein expression data. By comparing these regulatory networks, we find many tissue-specific regulations that are important for tissue identity. In particular, the tissue-specific TFs are found to regulate more genes than those expressed in multiple tissues, and the processes regulated by these tissue-specific TFs are closely related to tissue functions.Moreover, the regulations that are present in certain tissue are found to be enriched in the tissue associated disease genes, and these networks provide the molecular context of disease genes. Therefore, recognizing tissuespecific regulatory networks can help better understand the molecular mechanisms underlying diseases and identify new disease genes. | Weili GUO Lin ZHU Suping DENG Xingming ZHAO Deshuang HUANG | 2016 | Science China(Information Sciences)2016，59，7： | 1 |
| 13 | Development of monoclonal antibody-based enzyme linked immunosorbent assay for the herbicide chlorimuron-ethyl显示文摘 | ZHAO Jing YI Guoxiang HE Suping | 2006 | J Agric Food Chem2006，54，14： | 1 |
| 14 | Research on method and scheme of the optimization configuring between the hydropower and the thermal power under electricity market 显示文摘 | Zeng Ming Zhao Yongliang WU Zhifu YANG Suping MA Xin | 2004 | Water Resource And Power2004，22，4： | 1 |
| 15 | Developmentof a monoclonal antibody-based enzyme-linked immu-nosorbent assay for the herbicide chlorimuron-ethyl显示文摘 | Zhao Jing Yi Guoxiang He Suping | 2006 | Journal of Agricultural and Food Chemistry2006，54，14： | 1 |
| 16 | Sperm cryopreservation of yellow drum Nibea albiflora : A special emphasis on post-thaw sperm quality显示文摘 | Tongren Dai Enhui Zhao Gang Lu Kai Che Qiutao He Yonglin Lu Qiongshan Fang Hansheng Wang Leyun Zheng Suping Li Changjiang Huang Qiaoxiang Dong | 2012 | Aquaculture2012，，： | 1 |
| 17 | Enhanced a novel β-agarase production in recombinant Escherichia coli BL21(DE3) through induction mode optimization and glycerol feeding strategy显示文摘Agarases are hydrolytic enzymes that act on the hydrolysis of agar and have a broad range of applications in food,cosmetics and pharmaceutical industries. In this study, a glycerol feeding strategy based on induction mode optimization for high cell density and β-agarase production was established, which could effectively control acetate yield. First, exponential feeding strategy of glycerol with different overall specific growth rates(μ) was applied in the pre-induction phase. The results showed that the low μ(μ=0.2) was suggested to be the optimal for cell growth and β-agarase production. Second, the effects of induction temperature and the inducer concentration on cell growth and β-agarase production were investigated in the post-induction phase. When induced by isopropyl-β-d-thiogalactoside(IPTG), the strategy of 0.8 mmol/L IPTG induction at 20℃ was found to be optimal for β-agarase production. When cultivation was induced by continuous lactose feeding strategy of 1.0 g/(L·h), the β-agarase activity reached 112.5 U/mL, which represented the highest β-agarase production to date.Furthermore, the β-agarase was capable of degrading G. lemaneiformis powder directly to produce neoagarooligosaccharide, and the hydrolysates were neoagarotetraose(NA4) and neoagarohexaose(NA6). The overall research may be useful for the industrial production and application of β-agarase. | CHAN Zhuhua CHEN Xinglin HOU Yanping GAO Boliang ZHAO Chungui YANG Suping ZENG Runying | 2018 | Acta Oceanologica Sinica2018，37，2： | 0 |
| 18 | Multi-site observation of large-scale eddies in the surface layer of the Loess Plateau显示文摘This article aims to build a theory of atmospheric boundary layer turbulence under complex conditions. To achieve this goal, we constructed a multi-site observation and analysis method of atmospheric turbulence based on related principles.This method first requires verification for the ergodicity of the full-scale observation of surface-layer turbulence, which proves that eddies within a scale of 60 min during a four-site observation can easily meet ergodicity. Meanwhile, by applying the second-order structure function for the horizontal wind speed turbulence of a single site and upstream and downstream points, we verified the ergodicity of the turbulence observation. Comparing the turbulence spectrum to the second-order structure function for the horizontal wind speed from the four-site observation, a relatively high accordance was observed, proving the reasonability of the multi-site observation. Moreover, compared to the single-site observation, the four-site observation can improve the estimation accuracy of the surface-layer turbulence spectrum and vertical turbulent flux. As a result, we can describe the threedimensional structure of turbulence more accurately and comprehensively by combining analytical data from single-site and four-site observations. In summary, the multi-site turbulence observation method shows that the horizontal and vertical wind turbulence of the Baimiao plateau has a typical structure of a turbulence spectrum with clear spectral gaps. The result is in accordance with the scale of the turbulence spectral gaps obtained from the 6 h data. The horizontal wind speed is under the influence of the terrain, so its spectrum of large-scale eddies has higher fluctuations, but its spectral gaps can still be clearly distinguished. Although the spectral gaps of the temperature spectrum are not distinguishable, they still have the same scale as the spectral gap of the vertical and horizontal turbulence spectrum. Moreover, the temperature spectrum possesses typical structure characteristics of the boundary-layer turbulence spectrum. | Jinbei CHEN Xiaowen CHEN Wei JIA Ye YU Suping ZHAO | 2023 | Science China Earth Sciences2023，66，4： | 0 |
| 19 | Studies on kinetics of reactions between phycobiliproteins and hydroxyl radicals by a pulse radiolytic technique显示文摘Scavenging of hydroxyl radical (·OH) by phycobiliproteins (C-phycocyanin, Allophyco- cyanin and R-phycoerythrin) was studied by competitive kinetics methods. Hydroxyl radicals were generated from pulse radiolysis of aqueous systems saturated with nitrous oxide (N2O). The experimental results indicated that the three types of phycobiliproteins are all strong scavengers of· OH, the rate constants are around (2.8-5.6)×109 L·2 mol1 · s 1. | ZHANG Suping YAO Side WANG Wenfeng XIE Jie ZHANG Jianping ZHAO Jingquan JIANG Lijin | 2000 | Chinese Science Bulletin2000，45，10： | 0 |
| 20 | An Analysis of the Influence of Chinese Agriculture on National Economy and the Macroeconomic Effects显示文摘As a basic industry,agriculture has a far-reaching impact on national economy. Based on input-output tables of China in 2005 and2010,this paper gives a deep insight into the relationship between agriculture and national economy and its macroeconomic effects by the methods of input-output analysis,industrial correlation and macroeconomic effect analysis. The results show that the agricultural development is highly dependent on the national economy,but makes low contribution; agriculture contributes to promoting employment and improving the structure of national income distribution; despite the government's tax incentive,the agricultural equipments are updated slowly,and the corporate profits are at low level; agricultural export effect is far below the average industry level,but the import effect increases over the years,and final products are often used for domestic consumption. Finally,we set forth recommendations for improving the development of agriculture and national economy. | Ming GE Suping ZHAO | 2015 | Asian Agricultural Research2015，7，11： | 0 |
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