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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | Complications and monitoring of OKT3 therapy 显示文摘 | Thistlethwaite J R Stuart J K Mayes J T | 1998 | AM J Kidney Dis1998，11，2： | 2 |
| 4 | Organizational endowments and the performance of university start-ups显示文摘 | SHANE S STUART T | 2002 | Management Science2002，，48： | 1 |
| 5 | Transgenic zebrafish as sentinels for aquatic pollution显示文摘 | Carvan M J Dalton T P Stuart G W | 2000 | Ann N Y Acad Sci2000，919，： | 1 |
| 6 | Crystal structure of the human P58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I 显示文摘 | Juji T Stuart D | 1999 | Structure1999，7，4： | 1 |
| 7 | Tensile Testing of EP-823 and HT-9 After Irradiation in STIP Ⅱ 显示文摘 | Maloy Stuart A Romero T James M R | 2006 | Journal of Nuclear Materials2006，356，123： | 1 |
| 8 | Structure and recepter binding显示文摘 | Jackson T Stuart D I Fry E | 2003 | J Virol2003，91，： | 1 |
| 9 | Structure and receptor binding 显示文摘 | Jackson T King AM Stuart DI | 2003 | Virus Res2003，91，1： | 1 |
| 10 | The Geography of Opportunity: Spatial Heterogeneity in Founding Rates and the Performance of Bioteehnology Firms 显示文摘 | STUART T SORENSON O | 2003 | Research Policy2003，32，2： | 1 |
| 11 | Network Positions and Propensities to Collaborate:An investigation of strategic alliance formation in a high - technology in- dustry 显示文摘 | STUART T E | 1998 | Administrative Science Quarterly1998，，43： | 1 |
| 12 | Emerging ap- plications of stimuli-response polymer materials 显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nat Mater2010，9，： | 1 |
| 13 | An Op Amp transfer circuit to measurevoltages in battery stings 显示文摘 | WANG X STUART T | 2002 | Journal of Power Sources2002，109，2： | 1 |
| 14 | Selective buck - boost equalizer for series battery packs 显示文摘 | Tang M Stuart T | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，1： | 1 |
| 15 | Board Interlocks and the Propensity to Be Targeted in Private Equity Transactions 显示文摘 | STUART T E YIM S | 2010 | Journal of Financial Economics2010，97，1： | 1 |
| 16 | Organizational endowments and the performance of university start - ups 显示文摘 | Shane S Stuart T | 2002 | Management Science2002，48，1： | 1 |
| 17 | Structure and receptor binding显示文摘 | Jackson T Stuart D I Fry E | 2003 | Virus2003，91，： | 1 |
| 18 | Organizational endowments and the performance of university start - ups 显示文摘 | Shane S Stuart T E | 2000 | Management Science2000，48，1： | 1 |
| 19 | Embrittlement of Irradiated Ferritic/Martensitic Steels in the Absence of Irra diation Hardening 显示文摘 | Maloy Stuart A Romero T James M R | 2008 | Journal of Nuclear Materials2008，377，3： | 1 |
| 20 | Changes in global gene expression patterns during development and maturation of the rat kidney显示文摘 | Stuart R O Bush K T Nigam S K | 2001 | Proc Natl Acad Sci U S A2001，98，10： | 1 |
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