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| 1 | 采用特殊加工助剂改善绿色轮胎胎面胶性能显示文摘混炼白炭黑补强的S-SBR/BR轿车轮胎胎面胶料时,采用特殊的混炼程序可以获得最佳硅烷偶联的效果.在此混炼程序中,一段混炼仅加入生胶、填料、硅烷和油,二段混炼添加氧化锌、硬脂酸、防老剂和蜡.采用这种程序虽然可以获得最佳硅烷偶联效果,但可能会引起填料分散差和硅烷降解,而且还有添加的低熔点材料的润滑效应引起返炼初始胶料包辊性差的问题.分别采用常规混炼程序和特殊混炼程序制备了胶料,在一段混炼中分别添加和不添加特殊加工助剂.采用特殊程序混炼的胶料,在二段混炼中分别添加和不添加表面活性剂类加工助剂.一段混炼添加的加工助剂是专为不影响硅烷偶联效果而开发的.由于添加剂的润滑作用使返炼时混炼效果差,可以通过用表面活性剂类加工助剂代替硬脂酸加以改善.对未硫化胶的粘弹动态试验可以使混炼质量各个方面的单独量化成为可能.试验数据清楚地表明,在一段和二段混炼中添加的加工助剂对于白炭黑分散和硅烷偶联有积极的作用,而且它们的作用是叠加的.物理性能数据还显示出这些加工助剂的优点.对硫化样品进行的粘弹动态试验可用于预测轮胎使用性能,而且也再次证明了使用这些加工助剂的优越性. | Stone C R Menting K H Hensel M 涂学忠 | 2001 | 轮胎工业2001，21，4： | 18 |
| 2 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 3 | 职业教育基本问题访谈录(I) 职业教育是什么显示文摘全国教育科学“十五”规划国家一般课题《职业教育几个基本问题研究》(BJA010100)课题组就“职业教育的基本问题”对国内外职业教育界的专家、学者进行了访谈,使我们看到了对此问题的不同角度和层面的理解。这是一次思想的碰撞,有利于我们深化对职业教育基本问题的认识。本刊特将访谈记录分专题编辑处理,并从本期起连续刊发,本期论题为“职业教育是什么?” | 王明达 杨金土 刘来泉 余祖光 高奇 Josie Misko Susan Dave Jorn Saunder 钱景舫 Friedhelm Eicker James R Stone | 2006 | 中国职业技术教育2006，22，14： | 12 |
| 4 | Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis显示文摘The transcription factor nuclear factor κB(NF-κB) plays major roles in inflammatory diseases through regulation of inflammation and cell viability.Multiple sclerosis(MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system(CNS).It has been shown that NF-κB is activated in multiple cell types in the CNS of MS patients,including T cells,microglia/macrophages,astrocytes,oligodendrocytes,and neurons.Interestingly,data from animal model studies,particularly studies of experimental autoimmune encephalomyelitis,have suggested that NF-κB activation in these individual cell types has distinct effects on the development of MS.In this review,we will cover the current literature on NF-κB and the evidence for its role in the development of MS and its animal model experimental autoimmune encephalomyelitis. | Yuan Yue Sarrabeth Stone Wensheng Lin | 2018 | Neural Regeneration Research2018，13，9： | 10 |
| 5 | 采用大气压电喷雾(API-ESI)质谱和液体样品直接大体积进样技术检测饮用水和地下水中的苯基脲类和三嗪类除草剂显示文摘 | Neil Cullum Pete Stone | 2005 | 环境化学2005，24，2： | 9 |
| 6 | 分布区扩张的群体遗传学后果:类型与过程,以栎瘿蜂为模型系统显示文摘生物入侵是不均衡世界的一个永恒话题,尤其是当人类有意或无意地引入物种后,很多引入显然是无害的,但另外一些则有着严重的后果,会给入侵地的生物以至于整个生物群落造成影响,本文总结了分布区扩张的常见模式,概述了它们对遗传多样性和种群结构式样所造成的影响,描述了如何根据以一批遗传标记所得到的遗传多样性式样来推断入侵途径,来揭示伴随扩张选择和嘌变在形成种群遗传样式中的作用,本文对日益增多的群体遗传学方法进行了总结,这些技术可以用来在不同的时间尺度上推断种群规模所发生的巨大变化(瓶颈效应及种群扩张),最后,我们以欧洲栎瘿蜂(膜翅目,瘿蜂科,瘿蜂族)一系列入侵的数据为例对一些方法进行了说明,从500-10000年的时间尺度上,多态的等位酶位点上等位基因频率的数据表明:1)遗传多样性沿入侵路线呈不断下降的趋势,支持了冰河期避难所作为遗传多样性中心的作用;2)入侵地区的种群与该物种原产地的种群相比,遗传上的分化更为强烈,这种种群结构在空间上的变异可能是被栎瘿蜂开发的资源尤其是栎树寄主在斑块上出现变异的反映。 | GrahamN·Stone RachelJ·Atknson | 2002 | 生物多样性2002，10，1： | 9 |
| 7 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 8 | From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I显示文摘 | Morteza Naghavi Peter Libby Erling Falk S. Ward Casscells Silvio Litovsky John Rumberger Juan Jose Badimon Christodoulos Stefanadis Pedro Moreno Gerard Pasterkamp Zahi Fayad Peter H. Stone Sergio Waxman Paolo Raggi Mohammad Madjid Alireza Zarrabi Allen Bu | 2003 | Circulation: Journal of the American Heart Association2003，，14： | 6 |
| 9 | 比伐卢定对行经皮冠状动脉介入的急性冠状动脉综合征患者的作用:ACUITY试验的一项亚组分析 | Stone G.W. White H.D. Ohman E.M. 杜媛 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，8： | 6 |
| 10 | Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines显示文摘 | Scott M. Grundy James I. Cleeman C. Noel Bairey Merz H. Bryan Brewer Luther T. Clark Donald B. Hunninghake Richard C. Pasternak Sidney C. Smith Neil J. Stone | 2004 | Circulation: Journal of the American Heart Association2004，，2： | 6 |
| 11 | Unfolded protein response in myelin disorders显示文摘Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.Nevertheless,persistent,unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells.Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin,including multiples sclerosis,Charcot-Marie-Tooth disease,Pelizaeus-Merzbacher disease,vanishing white matter disease,spinal cord injury,tuberous sclerosis complex,and hypoxia-induced perinatal white matter injury.In this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders. | Wensheng Lin Sarrabeth Stone | 2020 | Neural Regeneration Research2020，15，4： | 5 |
| 12 | Dyslipidemia management in primary prevention of cardiovascular disease:Current guidelines and strategies显示文摘Cardiovascular disease is the leading cause of death in the United States. In 2010, the Centers for Disease Control and Prevention estimated that $444 billion was spent on cardiovascular diseases alone, about $1 of every $6 spent on health care. As life expectancy continues to increase, this annual cost will also increase, making costeffective primary prevention of cardiovascular disease highly desirable. Because of its role in development of atherosclerosis and clinical events, dyslipidemia management is a high priority in cardiovascular prevention. Multiple major dyslipidemia guidelines have been published around the world recently, four of them by independent organizations in the United States alone. They share the goal of providing clinical guidance on optimal dyslipidemia management, but guidelines differ in their emphasis on pharmacotherapy, stratification of groups, emphasis on lifestyle modification, and use of a fixed target or percentage reduction in low density lipoprotein cholesterol. This review summarizes eight major guidelines for dyslipidemia management and considers the basis for their recommendations. Our primary aim is to enhance understanding of dyslipidemia management guidelines in patient care for primary prevention of future cardiovascular risk. | Aditya D Hendrani Tolulope Adesiyun Renato Quispe Steven R Jones Neil J Stone Roger S Blumenthal Seth S Martin | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 13 | Cover Crops as Affecting Soil Chemical and Physical Properties and Development of Upland Rice and Soybean Cultivated in Rotation显示文摘Cover crops can provide changes in soil chemical and physical properties, which could allow a sustainable development of soybean and upland rice rotation in Brazilian Cerrado. The objective of this study was to determine the effects of cover crops(cultivated in the offseason) in the soybean-upland rice rotation(cultivated in the summer season) on the soil chemical and physical properties, yield components and grain yield of the cash crops. The experimental design was a randomized block design in factorial scheme 4 × 2 with six replications. Treatments were composed by four cover crops: fallow, millet(Pennisetum glaucum) + Crotalaria ochroleuca, millet + pigeon pea(Cajanus cajans), and millet + pigeon pea + Urochola ruziziensis in the offseason with one or two cycles of cover crops, with rice(Oryza sativa)or soybean(Glycine max) in the summer season. Cover crops alone provided no changes in soil chemical properties. However, the rotation cover crops/cash crops/cover crops/cash crops reduced p H, Al and H + Al and increased Ca, Mg, K and Fe contents in the soil. The cover crops millet + pigeon pea and millet + pigeon pea + U. ruziziensis improved soil physical properties in relation to fallow,especially in the 0–0.10 m soil layer. In spite of the improvement of the soil physical properties after two years of rotation with cover crops and cash crops, the soil physical quality was still below the recommended level, showing values of macroporosity, S index and soil aeration capacity lower than 0.10 m3/m3, 0.035 and 0.34, respectively. Upland rice production was higher under mixtures of cover crops than under fallow, mainly because of soil physical changes done by these mixtures of cover crops.Soybean grain yield was similar under all cover crops tested, but was higher after the rotation cover crops/upland rice/cover crops than after only one cycle of cover crops. | Adriano Stephan NASCENTE Luis Fernando STONE | 2018 | Rice science2018，25，6： | 5 |
| 14 | 山东东平洪顶山摩崖刻经考察显示文摘山东石刻佛经考察是山东省石刻艺术博物馆、中国社会科学院世界宗教研究所、德国海德堡学术院等合作开展的项目。经国家文物局批准,2003-2004年对山东省东平县新发现的洪顶山北朝摩崖刻经进行了调查。工作中采用多项技术手段,在文字辨识与对遗迹现状及地理环境的把握等方面均有收获。考察本着重视第一手基础资料的原则,汇集人文学科方法与自然科学技术手段,在地理信息与文字辨识,以及佛经佛名内涵考订等方面,取得了新的成果。 | The Stone Inscription Art Museum of Shandong Province and Others | 2006 | 文物2006，，12： | 4 |
| 15 | Angiographic Patterns of In-Stent Restenosis: Classification and Implications for Long-Term Outcome显示文摘 | Roxana Mehran George Dangas Andrea S. Abizaid Gary S. Mintz Alexandra J. Lansky Lowell F. Satler Augusto D. Pichard Kenneth M. Kent Gregg W. Stone Martin B. Leon | 1999 | Circulation1999，，18： | 4 |
| 16 | The role of antioxidants and pro-oxidants in colon cancer显示文摘This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic CRC.If pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and genotoxicity.Cigarette smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC risk.These risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this review.While a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less certain.It is clear that not every micronutrient with antioxidant activity can prevent CRC.It is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically evaluated.Increasing evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other'non-alpha-tocopherol'forms of vitamin E(e.g.,tocotrienols)might be effective.Aspirin is an antioxidant and its consumption is linked to a decreased risk of CRC. | William L Stone Koyamangalath Krishnan Sharon E Campbell Victoria E Palau | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 4 |
| 17 | 全球气候变暖对人类健康的危害显示文摘两年前,三位著名环境科学家提出一个惊人的观点:厄尔尼诺(El Nino)——沿着秘鲁海岸南向的暖流,是促使南美洲1991年致死性霍乱暴发的原凶。他们认为太平洋增暖的环流刺激隐匿霍乱菌的浮游生物生长,为霍乱在南美洲19个国家流行创造了条件,终使成千上万人濒于死亡。 | Stone R 汤林华 | 1995 | 国外医学(寄生虫病分册)1995，22，5： | 4 |
| 18 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 19 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 20 | Pulse vaccination strategy in the SIR epidemic model显示文摘 | Boris Shulgin Lewi Stone Zvia Agur | 1998 | Bulletin of Mathematical Biology1998，，6： | 3 |
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