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| 1 | TRIPs有关地理标志规定的实施显示文摘 | ROBERT STOLL 汪泽 | 2000 | 中华商标2000，，3： | 22 |
| 2 | 地物热辐射方向性影响主因子的揭示──提高辐射温度方向性观测精度的新途径及数据剖析显示文摘排除影响地物热辐射方向性三因子以外的噪声,即消除热红外传感器随着测 量角度的变化所接收到的组分变化所引起的噪声;消除前后测量的时间差里地表热量 平衡变化所引起的噪声,这是多角度遥感测量中的难题,长期以来一直没有得到解决. 提出利用“热像仪-定面积法”和“双传感器-同步法”进行测定.试验结果表明,以前 的几种方法所观测到的数据离散、无规律,而利用本方法获取的数据,呈现出相当有规 律的方向性分布.从而揭示了影响地物目标热辐射方向性的主要因子和它们各自的影 响程度. | 张仁华 孙晓敏 李召良 M.P. Stoll 苏红波 唐新斋 | 2000 | 中国科学(E辑)2000，30，z1： | 12 |
| 3 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 4 | Inflammation and Atherosclerosis: Novel Insights Into Plaque Formation and Destabilization显示文摘 | Guido Stoll Martin Bendszus | 2006 | Stroke2006，，7： | 4 |
| 5 | Expression of Tissue Factor in High-Grade Carotid Artery Stenosis: Association With Plaque Destabilization显示文摘 | Sebastian Jander Matthias Sitzer Angélique Wendt Michael Schroeter Martin Buchkremer Mario Siebler Wolfram Müller Wilhelm Sandmann Guido Stoll | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 3 |
| 6 | Role of discs large homolog 5显示文摘在 2004,在磁盘的基因变化的一个协会大相当或相同的事物 5 (DLG5 ) 有煽动性的肠疾病(IBD ) 的基因在二件大欧洲学习样品被描述。新奇 IBD 危险性基因引发在 CD 和 IBD 上调查它的效果分别地,在 Crohn 疾病的原因论有关发现的起始的协会和它的角色的有效性导致争论调查结果和进行中的讨论的大量的研究的 DLG5 的起始的报告。这评论试图总结知识的当前的状态并且把报导调查结果放在复杂疾病的当前的概念的上下文。这象基因基因和基因环境相互作用一样包括在不同人口之间的统计力量,显型差别和基因异质的方面。 | Frauke Friedrichs Monika Stoll | 2006 | World Journal of Gastroenterology2006，12，23： | 3 |
| 7 | Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension显示文摘AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate(NO-cGMP) pathway was investigated. Expression and localization of PDE-5, the enzyme that converts vasodilating cGMP into inactive 5'-GMP, was in the focus of the study. Hepatic gene expression of key components of the NO-cGMP pathway was determined by qRT-PCR: Endothelial NO synthase(eNOS), inducible NO synthase(iNOS), soluble guanylate cyclase subunits α1 and β1(sGCa1, sGCb1), and PDE-5. Hepatic PDE-5 protein expression and localization were detected by immunohistochemistry. Serum cGMP concentrations were measured using ELISA. Acute effects of the PDE-5 inhibitor Sildenafil(0.1 mg/kg or 1.0 mg/kg) on portal and systemic hemodynamics were investigated using pressure transducers.RESULTS Hepatic gene expression of eNOS(2.2-fold; P = 0.003), sGCa1(1.7-fold; P = 0.003), sGCb1(3.0-fold; P = 0.003), and PDE-5(11-fold; P = 0.003) was increased in cirrhotic livers compared to healthy livers. Overexpression of PDE-5(7.7-fold; P = 0.006) was less pronounced in fibrotic livers. iNOS expression was only detected in fibrotic and cirrhotic livers. In healthy liver, PDE-5 protein was localized primarily in zone 3 hepatocytes and to a lesser extent in perisinusoidal cells. This zonation was disturbed in cirrhosis: PDE-5 protein expression in perisinusoidal cells was induced approximately 8-fold. In addition, PDE-5-expressing cells were also found in fibrous septa. Serum cGMP concentrations were reduced in rats with cirrhotic livers by approximately 40%. Inhibition of PDE-5 by Sildenafil caused a significant increase in serum cGMP concentrations [+ 64% in healthy rats(P = 0.024), + 85% in cirrhotic rats(P = 0.018)]. Concomitantly, the portal venous pressure was reduced by 19% in rats with liver cirrhosis. CONCLUSION Overexpression and abrogated zonation of PDE-5 likely contribute to the pathogenesis of cirrhotic portal hypertension. PDE-5 inhibition may therefore be a reasonable therapeutic approach for portal hypertension. | Denise Schaffner Adhara Lazaro Peter Deibert Peter Hasselblatt Patrick Stoll Lisa Fauth Manfred W Baumstark Irmgard Merfort Annette Schmitt-Graeff Wolfgang Kreisel | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 8 | Long non-coding RNA Databases in Cardiovascular Research显示文摘With the rising interest in the regulatory functions of long non-coding RNAs(lnc RNAs)in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensive and integrative data for all aspects of these versatile molecules.Recently, a variety of public data repositories that specialized in lnc RNAs have been developed,which make use of huge high-throughput data particularly from next-generation sequencing(NGS) approaches. Here, we provide an overview of current lnc RNA databases covering basic and functional annotation, lnc RNA expression and regulation, interactions with other biomolecules, and genomic variants in?uencing the structure and function of lnc RNAs. The prominent lnc RNA antisense noncoding RNA in the INK4 locus(ANRIL), which has been unequivocally associated with coronary artery disease through genome-wide association studies(GWAS), serves as an example to demonstrate the features of each individual database. | Frank Rühle Monika Stoll | 2016 | Genomics, Proteomics & Bioinformatics2016，14，4： | 2 |
| 9 | 独特型多肽主动免疫对自发性自身免疫小鼠肾脏的保护作用显示文摘目的 :既往的动物研究发现一组致病性的自身抗体IdLNF1 ,其表达与 (SWR×NZB)F1 (SNF1 )的狼疮性肾炎 (LN)发病有关。特异性T细胞参与了对这种抗体的识别和介导作用。来自于某一IdLNF1重链可变区的独特型多肽片段 62 73(aa62 73)也具有体外刺激这种特异性T细胞增生的作用。如果给予动物aa62 73免疫治疗 ,有可能改变SNF1的LN发病进程。 方法 :我们对尚未患LN的SNF1 ,MRL/ +,NZB/NZW小鼠进行aa62 73注射免疫。用来自于抗疟抗体重链可变区的多肽片段Mal作对照。并观察不同种系和不同年龄SNF1经治小鼠肾脏病理的改变。 结果 :治疗组小鼠 2 4周时肾脏病理损害明显低于对照组。于 1 4周起SNF1治疗组的肾脏损害也明显低于对照。 结论 :来自于自身抗体的独特型多肽片段对自发性自身免疫病小鼠的肾脏具有保护作用 。 | 姜枫 Matthew Stoll Jerrie Gavalchin | 2002 | 肾脏病与透析肾移植杂志2002，11，2： | 2 |
| 10 | Orthotopic Liver Transplantation in Human-Immunodeficiency-Virus-Positive Patients in Germany显示文摘 | E. Anadol S. Beckebaum K. Radecke A. Paul A. Zoufaly M. Bickel F. Hitzenbichler T. Ganten J. Kittner M. Stoll C. Berg S. Manekeller J. C. Kalff T. Sauerbruch J. K. Rockstroh U. Spengler Raffaele Bruno | 2012 | AIDS Research and Treatment2012，，： | 2 |
| 11 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 12 | The dynamic neutralization system for the spine: a multi-center study of a novel non-fusion system显示文摘 | Thomas M. Stoll Gilles Dubois Othmar Schwarzenbach | 2002 | European Spine Journal2002，，2： | 2 |
| 13 | Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells显示文摘 | Fang X Weintraub N L Stoll L L Spector A A | 1999 | Hypertension1999，34，6： | 1 |
| 14 | SLICC/ ACR damage index is valid and renal and pulmonary organ scores are predictors of severe outcome in patients with systemic lupus erythematosus显示文摘 | Seifert B Isenberg DA | 1996 | Br J Rheumatol1996，35，2： | 1 |
| 15 | The dynamic neutralization system for the spine:a muhieenter study of a novel non fusion system显示文摘 | Dubois G Schwarzenbach O | 2002 | J Eur Spine J2002，，： | 1 |
| 16 | Earlyonset sepsis in very low birth weight neonates:a report form the National Institute of Child Health and Human Development Neonatal Research Network显示文摘 | Stoll B J Gordon T Korones S B | 1996 | Pediatrics1996，129，1： | 1 |
| 17 | Omphalocele and gastros- chisis and associated malformations 显示文摘 | Stoll C Alembik Y Dott B | 2008 | Am J Med Genet A2008，146，10： | 1 |
| 18 | Perfectionism and per-formance in a new basketball training task:Does strivingfor perfection enhance or undermine performance?显示文摘 | Stoll O Lau A Stoeber J | 2008 | Psychology of Sport and Exercise2008，9，5： | 1 |
| 19 | Modelling of sand behavior under earthquake excitation显示文摘 | PIETRUSZCZAK S STOLLE D F E | 1987 | Int J Numer Analyt Methods Goemech1987，11，： | 1 |
| 20 | The dynamics of stock index and stock index futures returns显示文摘 | Stoll H R Whaley R E | 1990 | Journal of Financial and Quantitative Analysis1990，25，： | 1 |
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