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| 1 | Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis显示文摘OBJECTIVE: The fatality of cancer is mostly dependent on the possibility of occurrence of metastasis. Thus, if the development of metastasis can be prevented through novel therapeutic strategies targeted against this process, then the success of cancer treatment will drastically increase. In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis and curcumin on the metastatic liver cell line HepG2, and also assessed the anticancer property of the extract.METHODS: Cells were cultured and treated with graded concentrations of test substances for 24, 48, or 72 h with provisions made for negative controls. Treated cells were assessed as follows: nanotechnologically—atomic force microscopy(AFM) was used to determine cell stiffness; biochemically—cell cytotoxicity, glutathione level and adenosine triphosphate status, caspase activation and mitochondrial toxicity were considered; and microbiologically—a carrot disk assay was used to assess the anticancer property of the extract of K. senegalensis.RESULTS: Curcumin and K. senegalensis increased the cell stiffness by 2.6-and 4.0-fold respectively, indicating their antimetastatic effects. Corresponding changes in redox(glutathione level) and energy(adenosine triphosphate) status of the cells were also demonstrated. Further mechanistic studies indicated that curcumin was not mitotoxic in HepG2 cells unlike the K. senegalensis extract. In addition, the extract potently inhibited the Agrobacterium tumefaciens-induced genetic transformation based on carrot disk assay.CONCLUSION: Cell elasticity measurement data, using AFM, strongly suggested, for the first time, that both curcumin and the extract of K. senegalensis exhibited antimetastatic properties on HepG2 cells. | Jeremiah Olorunjuwon Olugbami Robert Damoiseaux Bryan France Michael A. Gbadegesin Adam Z. Stieg Shivani Sharma Oyeronke A. Odunola James K. Gimzewski | 2017 | Journal of Integrative Medicine2017，15，3： | 2 |
| 2 | AHA Scientific:Recom- mendations for the management of intracranial arteriovenous malformations: a statement for heahhcare professionals from a special writing group of the stroke Council,American Stroke Association显示文摘 | Ogilvy CS Stieg PE Awad I | 2001 | Stroke2001，32，6： | 1 |
| 3 | Papillary cystic neoplasm of the pancreas:a curable pancreatic tumor显示文摘 | Kaufman SL Reddick RL Stiege M | 1986 | Wold J Surg1986，10，5： | 1 |
| 4 | Solitary fibrous tumor with multiple intracranial and spinal lesions:case report显示文摘 | Takenouchi T Pannullo SC Stieg PE | 2011 | Neurosurgery2011，68，4： | 1 |
| 5 | Intracranial pressure is still number i de- spite BEST:TRIP study显示文摘 | Hard R Stieg PE | 2013 | World Neurosurg2013，79，56： | 1 |
| 6 | Neural stem cells may be uniquely suited for combined gene therapy and cell replacement:Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury显示文摘 | Park KI Himes BT Stieg PE | | 0，，01： | 1 |
| 7 | Neural stem cells may be uniquely suited for combined gene therapy and cell replacement:evidence from engraftment of neurotrophin-3-expressing stem cells in hypoxic-ischernic brain injury显示文摘 | Park K I Himes B T Stieg P E | | 0，，01： | 1 |
| 8 | Endoscopic transsphenoidal pituitary surgery with intraoperative magnetic resonance imaging 显示文摘 | Schwartz TH Stieg PE Anand VK | 2006 | Neurosurgery2006，58，1： | 1 |
| 9 | Intracranial pressure is still number 1 despite BEST: TRIP study 显示文摘 | Hartl R Stieg PE | 2013 | World Neurosurg2013，79，56： | 1 |
| 10 | Hyponatremia in the neurosurgical patient : epidemiology, pathophysiology, diagnosis, and management 显示文摘 | Fraser JF Stieg PE | 2006 | Neurosurgery2006，59，2： | 1 |
| 11 | Stemal wound reconstruction with trauverse plate fixation显示文摘 | CICILIONI O J STIEG F H PAPANICOI AOU G | 2005 | Plast Reconstr Surg2005，115，5： | 1 |
| 12 | The Im-pact of an Informational Self-Management Intervention onthe Association between Control and Illness Uncertaintybefore and Psychological Distress after Radiotherapy显示文摘 | Stiegelis H E Hagedoom M Sanderman R | 2004 | Psychooncology2004，13，4： | 1 |
| 13 | Hyponatremia in the neurosurgical patient : epidemiology, pathophysiology, diagnosis, and management 显示文摘 | Fraser JF Stieg PE | 2006 | Neurosurgery2006，59，2： | 1 |
| 14 | Endoscopic transsphenoidal pituitary surgery with intraoperative magnetic resonance imaging显示文摘 | Schwartz TH Stieg PE Anand VK | 2006 | Operative Neurosurg2006，58，1： | 1 |
| 15 | Hyponatremia in the neurosurgical patient: epidemiology, pathophysiology, diagnosis, and management 显示文摘 | Fraser JF Stieg PE | 2006 | Neumsurgery2006，59，2： | 1 |
| 16 | Neural stem cells may be suited for combined gene therapy and cell replacemant:Evidence from engraftment of Neurotrophin -3 -expressing stem cells in hypoxic-ischemic brain injury显示文摘 | Park KI Himes BT Stieg PE | 2006 | Exp Neurol2006，199，1： | 1 |
| 17 | Can timing of tra- cheal extubation predict improved outcomes after cardiac surgery显示文摘 | Camp SL Stamou SC Stiege RM | 2009 | HSR Proc Intensive Care Cardiovasc Anesth2009，1，2： | 1 |
| 18 | Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxie-ischemic brain injury 显示文摘 | Park KI Himes BT Stieg PC | 2006 | Exp Neurol2006，199，1： | 1 |
| 19 | AHA Scientific Statement: recommendations for the management of intracranial arteriovenous malformations: a statement for health-care professionals from a special writing group of the Stroke Council, American Stroke Association显示文摘 | Ogilvy CS Stieg PE Awad I | 2001 | Stroke2001，32，： | 1 |
| 20 | Development and Implementation of Intraoperative Magnetic Resonance Imaging and Its Neurosurgical Applications显示文摘 | Peter McL. Black Thomas Moriarty Eben Alexander Philip Stieg Eric J. Woodard P. Langham Gleason Claudia H. Martin Ron Kikinis Richard B. Schwartz Ferenc A. Jolesz | 1997 | Neurosurgery1997，，4： | 1 |
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