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| 1 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 2 | Rapid and flexible segmentation of electron microscopy data using few-shot machine learning显示文摘Automatic segmentation of key microstructural features in atomic-scale electron microscope images is critical to improved understanding of structure–property relationships in many important materials and chemical systems.However,the present paradigm involves time-intensive manual analysis that is inherently biased,error-prone,and unable to accommodate the large volumes of data produced by modern instrumentation.While more automated approaches have been proposed,many are not robust to a high variety of data,and do not generalize well to diverse microstructural features and material systems.Here,we present a flexible,semi-supervised few-shot machine learning approach for segmentation of scanning transmission electron microscopy images of three oxide material systems:(1)epitaxial heterostructures of SrTiO_(3)/Ge,(2)La_(0.8)Sr_(0.2)FeO_(3) thin films,and(3)MoO_(3) nanoparticles.We demonstrate that the few-shot learning method is more robust against noise,more reconfigurable,and requires less data than conventional image analysis methods.This approach can enable rapid image classification and microstructural feature mapping needed for emerging high-throughput characterization and autonomous microscope platforms. | Sarah Akers Elizabeth Kautz Andrea Trevino-Gavito Matthew Olszta Bethany E.Matthews Le Wang Yingge Du Steven R.Spurgeon | 2021 | npj Computational Materials2021，，1： | 3 |
| 3 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 4 | Optical absorption and electron paramagnetic resonance of Fe ions in KDP crystals 显示文摘 | GARCES N Y STEVENS K T HALLIBURTON LE | 2001 | J Cryst Growth2001，225，24： | 1 |
| 5 | The classical complement cascade mediates CNS synapse elimination 显示文摘 | Stevens B Allen N J Vazquez LE | 2007 | Cell2007，131，6： | 1 |
| 6 | Risk factors for epidemic Xanthomonas maltophilia infection/coloniza tion in inten-sive care unit patients 显示文摘 | Villarino ME Stevens LE Schable B | 1992 | Infect Control Hosp Epidemiol1992，13，2： | 1 |
| 7 | Serial measurements of C-reactive protein after acute myocardial infarction in predicting one-year outcome显示文摘 | Dimitrijevic O Stojcevski BD Steven LE | 2006 | Int Heart2006，47，6： | 1 |
| 8 | Reexamination of convective diffusion/drug dissolution in a laminar flow channel:accurate prediction of dissolution rate显示文摘 | MISSEL PJ STEVENS LE MAUGER JW | 2004 | Pharm Res2004，21，12： | 1 |
| 9 | The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/C-myc rearrangement显示文摘 | Steven Le Gouill Pascaline Talmant Cyrille Touzeau | 2007 | Haematologica2007，92，： | 1 |
| 10 | Mice with megabase humanization of their immunoglobulin genes gener- ate antibodies as efficiently as normal mice显示文摘 | MURPHY AJ MACDONALD LE STEVENS S | 2014 | Proc Natl Acad Sci USA2014，111，14： | 1 |
| 11 | A large, random ized clinical trial of a silver-impregnated urinary catheter: lack of efficacy and staphylococcal superinfection显示文摘 | Riley DK Classen DC Stevens LE | 1995 | Am J Med1995，98，4： | 1 |
| 12 | Multi-detector row CT arti- facts that mimic disease显示文摘 | Cody DD Stevens DM Ginsberg LE | 2005 | Radiology2005，236，3： | 1 |
| 13 | An ex vivo evaluation of an inflatable bone tamp used to reduce fractures within vertebral bodies under load显示文摘 | Belkoff SM Jasper LE Stevens SS | 2002 | Spine (Phila Pa 1976)2002，27，15： | 1 |
| 14 | Circulating 25 - Hydroxyvitamin D and Risk of Kidney Cancer Cohort Consortium Vitamin D Pooling Project of Rarer Cancers显示文摘 | Gallieehio L Moore LE Stevens VL | 2010 | American Jour- nal of Epidemiology2010，172，1： | 1 |
| 15 | Breast cancer with synchro nous metastases : survival impact of exclusive locoregional radiother apy显示文摘 | Le Scodan R Stevens D Brain E | 2009 | J Clin Oncol2009，27，9： | 1 |
| 16 | Multi-detector row CT artifacts that mimic disease显示文摘 | Cody DD Stevens DM Ginsberg LE | 2005 | Radiology2005，236，3： | 1 |
| 17 | An ex vivo evaluation of an inflatable bone tamp used to reduce fractures within vertebral bodies under load显示文摘 | Belkoff SM Jasper LE Stevens SS | 2002 | Spine2002，27，15： | 1 |
| 18 | Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever显示文摘 | Hensley LE Stevens EL Yan SB | 2007 | J Infect Dis2007，1962，： | 1 |
| 19 | The classical complement cascade mediates CNS synapse elimination显示文摘 | Stevens B Alien N J Vazquez LE | 2007 | Cen2007，131，： | 1 |
| 20 | Risk factors for epi-demic Xanthomonas maltop-hila infection/colonization in intensivecare unit patients显示文摘 | Villarino ME Stevens LE Schable B | 1992 | Infect control Hosp Epidemiol1992，13，4： | 1 |
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