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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs显示文摘 | Raffaella Gozzelino Carme Sole Nuria Llecha Miguel F Segura Rana S Moubarak Victoria Iglesias-Guimarais M Jose Perez-Garcia Stephanie Reix Jisheng Zhang Nahuai Badiola Daniel Sanchis Jose Rodriguez-Alvarez Ramon Trullas Victor J Yuste Joan X Comella | 2008 | Cell Research2008，18，10： | 4 |
| 3 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 4 | Rare presentation of primary (AL) amyloidosis as gastrointestinal hemorrhage without systemic involvement显示文摘We are reporting a rare case of a patient with primary(AL) amyloidosis presenting with an acute non-varicealupper gastrointestinal hemorrhage in the absence ofother systemic involvement. The case report involves a58-year-old woman with significant cardiac history andhereditary blood disorder who came in complaining ofabdominal pain and coffee-ground emesis for two days.Computed tomography(CT) scan of the abdomen andpelvis with contrast revealed segmental wall thickeningof the proximal jejunum with hyperdense, heterog-enous luminal content. Similar findings were evident inthe left lower small bowel region, suspicious for smallbowel hematoma and the possibility of intraluminalclots. Esophagogastroduodenoscopy performed postresuscitation showed punctate, erythematous lesionsthroughout the stomach as well as regions of smallbowel mucosa that appeared scalloped, ulcerated, andhemorrhaged on contact. Despite initial treatment for immunostain-positive focal cytomegalovirus gastritis, follow-up esophagogastroduodenoscopy after two months continued to demonstrate friable and irregular duodenal mucosa hinting at a different underlying etiol-ogy. Pathology reports from analyses of biopsy samples highlighted infiltration and expansion of the lamina pro-pria and submucosa. Subsequent staining with congo red/crystal violet and appropriate subtyping established the diagnosis of AL(kappa)-type amyloidosis. The sig-nificance of this case lies in the fact that our patient did not have the typically seen diagnostic systemic involvements-namely of heart and kidneys-usually seen in primary(AL) amyloidosis patients. It was the persis-tent endoscopic findings and biopsy results which gave clues to the physicians regarding the possibility of an abnormal protein-deposition entity. | Mohammad F Ali Anik Patel Stephanie Muller David Friedel | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | Knowledge sharing: Context, confusion and controversy 显示文摘 | Scott F Stuart D Stephanie J W | 2003 | International Journal of Project Management2003，21，3： | 1 |
| 7 | Fakeability and correlates of the perception and preference inventory显示文摘 | ADRIAN F STEPHANIE C | | 0，，04： | 1 |
| 8 | A Detailed Comparative Study of High-Resolu- tion Ultrasound and Micro-Computed Tomography for Detection of Ar- thritic Bone Erosions 显示文摘 | Stephanie F Sarah O | 2011 | Arthritis & Rheumatism2011，63，5： | 1 |
| 9 | Waste Treatment and Biogas Quality in Small-scale Agricultural Digesters显示文摘 | Stephanie Lansing Raul Botero Jay F Martin | 2008 | Bioresource Technology2008，155，99： | 1 |
| 10 | Diversity of the cassiicolin gene in Corynespora cassiicola and relation with the pathogenicity in Hevea brasiliensis显示文摘 | MARINE DKRIS F STEPHANIE G | 2014 | Fungal Biology2014，118，1： | 1 |
| 11 | Inhibition of vascularization in rabbit corneals by heparin, cortisone pellets显示文摘 | Linbisa N Jadith F Stephanie T | 1986 | Invest Ophthalmol Vis Sci1986，27，4： | 1 |
| 12 | Wurmian deglaciation of western Lake Geneva (Switzerland) based on seismic stratigraphy显示文摘 | Julien F Stephanie G Andre P | 2011 | Quaternary Science Reviews2011，30，3： | 1 |
| 13 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate 显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 14 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 15 | Histological changes induced by dietary phospholipids in intestine and liver of common carp(Cyprinus carpio)larvae显示文摘 | Stephanie F Inge G Anne - Marie E | 1998 | Aquaculture1998，161，： | 1 |
| 16 | Simultaneous EEG and fM- RI recordings (EEG-fMRI) in children with epilepsy显示文摘 | Moeller F Stephani U Siniatchkin M | 2013 | Epilep- sia2013，54，6： | 1 |
| 17 | Architecture for an Artificial Immune System显示文摘 | Stenen H Stephanie F | 2000 | Evolutionary Computation2000，7，1： | 1 |
| 18 | Field study of pulsed air sparging for remediation of petroleum hydrocarbon contaminated soil and groundwater显示文摘 | Yang X M Dennis B Stephanie F | 2005 | Environmental Science and Technology2005，39，18： | 1 |
| 19 | Use of an ecological treatment system (ETS) for removal of nutrients from dairy wastewater 显示文摘 | STEPHANIE L L JAY F M | 2006 | Ecological Engineering2006，28，： | 1 |
| 20 | Oxidative STESS is increased in critically ill patients with acute renal failure显示文摘 | Jonathan H Ellen M Stephanie F | 2004 | J Am Soc Nephrol2004，15，9： | 1 |
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