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| 1 | Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation显示文摘AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor KB (NF-KB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NFKB activation in a dose- and strain-dependent manner. In contrast, NF-KB activation in response to challenge with tumor necrosis factor-α(TNF-α) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NFKB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-a, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation. | Christian U Riedel Francis Foata David Philippe Oskar Adolfsson Bernhard J Eikmanns Stephanie Blum | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 3 | Pregnancy outcome when both members of a couple have balanced translocations 显示文摘 | Stephanie A C Wendy R U Debra D | 1995 | Obstet Gynecol1995，85，5： | 1 |
| 4 | Simultaneous EEG and fM- RI recordings (EEG-fMRI) in children with epilepsy显示文摘 | Moeller F Stephani U Siniatchkin M | 2013 | Epilep- sia2013，54，6： | 1 |
| 5 | Transition issues forbenign epilepsy with centrotemporal spikes,nonlesional focalepilepsy in otherwise normal children, childhood absenceepilepsy, and juvenile myoclonic epilepsy 显示文摘 | Camfield CS Berg A Stephani U | 2014 | Epilepsia2014，553，： | 1 |
| 6 | Interictal and postictal per- formances on dichotic listening test in children with focal epilep- sy显示文摘 | Carlsson G Wiegand G Stephani U | 2011 | Brain and Cognition2011，76，2： | 1 |
| 7 | The natural history of myoclonie astatic epilepsy (Doose syndrome)and Lennox-Gastaut syndrome 显示文摘 | Stephani U | 2006 | Epilepsia2006，47，： | 1 |
| 8 | Simultaneous EEG and fMRI recordings ( EEG - fMRI) in children with epilepsy 显示文摘 | Moeller F Stephani U Siniatchkin M | 2013 | Epilepsia2013，54，6： | 1 |
| 9 | High-yield 5-keto-D-gluconic acid formation is mediated by soluble and membrane-bound gluconate-5-dehydrogenases of Gluconobacter oxydans显示文摘 | Marcel Merfort Herrmann U Stephanie BM | | 0，，2： | 1 |
| 10 | Induction of epileptic negative myoclonus by oxcarbazepine in symptomatic epilepsy显示文摘 | Hahn A Fischenbeck A Stephani U | 2004 | Epileptic Disord2004，6，4： | 1 |
| 11 | The natural history of myoclonic astatic epilepsy (Doose Syndrome) and Lennox-Gastaut Syndrome 显示文摘 | Stephani U | 2006 | Epi- lepsy2006，47，2： | 1 |
| 12 | Benign idiopathic partial epilepsy and brain lesion显示文摘 | Stephani U Doose H | 1999 | Epilepsia1999，40，3： | 1 |
| 13 | In vitro replication of hepatitis E virus(HEV)genomes and of an HEV replicon expressing green fluorescent protein显示文摘 | Emerson S U Nguyen H Graff J Stephany D A Brockington A Purcell R H | 2004 | J Virol2004，78，9： | 1 |
| 14 | In vitro replication of hepatitis E virus(HEV)genomes and of an HEV replicon expressing green fluorescent protein显示文摘 | Emerson S U Nguyen H Graff J Stephany D A Brockington A Purcell R H | 2004 | J Virol2004，78，9： | 1 |
| 15 | Event-based sonifieation of EEG rhythms in real time显示文摘 | Baier G Hermann T Stephani U | 2007 | Clinical Neurophysiology2007，118，6： | 1 |
| 16 | Induction of epileptic negative myoclonus by oxcarbazepine in symptomatic epilepsy 显示文摘 | HAHN A FISCHENBECK A STEPHANI U | 2004 | Epileptic Disord2004，6，2： | 1 |
| 17 | Poxvirus orthologous clusters:toward defining the minimum essential poxvirus genome显示文摘 | Chris U Stephanie S Arwen L | 2003 | J Virol2003，77，13： | 1 |
| 18 | Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitor显示文摘 | Stephanie B Axel U Henrik D | 2003 | J Biol Chem2003，278，15： | 1 |
| 19 | Voltage-gated calcium channels in the etiopathogenesis and treatment of absence epilepsy显示文摘 | Weiergraber M Stephani U Kohling R | 2010 | Brain Res Rev2010，62，2： | 1 |
| 20 | The spectrum from BECTS to LKS:the rolandic EEG trait e impact on cognition显示文摘 | Stephani U Carlsson G | 2006 | Epilepsia2006，47，2： | 1 |
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