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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Reversal of Type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents 显示文摘 | Inge TH Miyano G Bean J | 2009 | Pediatrics2009，123，1： | 1 |
| 3 | Percutaneous left ventricular assist devices in acute myocardial infarction complicated by cardiogenic shock显示文摘 | HOLGER T SMALI ING R W SCHUI ER G C | 2007 | Eur HeartJ2007，17，： | 1 |
| 4 | Cardiac index monitoring by pulse contour analysis and thermodilution after pediatric cardiac surgery显示文摘 | Fakler U Pauli CH Bal|ing G | 2007 | J Thorac Cardiovasc Sttrg2007，133，1： | 1 |
| 5 | Superconductor Film growth on LaGaO3 Substrates by Liquid Phase epitaxy 显示文摘 | Belt R F Ings J Diercks G | 1990 | Applied Physics Letters1990，56，： | 1 |
| 6 | Optimal and nonlinear decoupling control of systems with sandwiched backlash显示文摘 | TAO G MA X L ING Y | 2001 | Automatica2001，37，： | 1 |
| 7 | Histological changes induced by dietary phospholipids in intestine and liver of common carp(Cyprinus carpio)larvae显示文摘 | Stephanie F Inge G Anne - Marie E | 1998 | Aquaculture1998，161，： | 1 |
| 8 | Flow patterns of super-high-rate anaerobic bioreactor显示文摘 | Chen X G Zheng P Guo Y J Mahmood Q Tang C J I)ing S | 2010 | Bioresource Technology2010，101，77： | 1 |
| 9 | Synthesis of methanol:Part 1 catalysts and kinetics显示文摘 | DENNY P J JENN INGS J R SPENCER M S WAUGH K C | 1988 | Appl Catal1988，36，： | 1 |
| 10 | Risk factors for lower urinary tract symptoms in women 40 to 60 years of age显示文摘 | Al ing M?l er L Lose G J?rgensen T | | 0，，03： | 1 |
| 11 | Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury显示文摘 | PAPAHARALAMBUS C A IENDL G R ING K K | 2007 | Trends Cardiovasc Med2007，17，2： | 1 |
| 12 | Riskfactors for post-stroke depression显示文摘 | VESTERGAARD K INGE MANN NIELSEN M | 1995 | Acta Psychiatr Scand1995，92，： | 1 |
| 13 | Reference ranges for muscle carnitine concentration in children 显示文摘 | Angsten G Cederblad G Meur]ing S | 2003 | Ann Clin Biochem2003，40，4： | 1 |
| 14 | Aromatic compounds produced by Periconia atropur purea ,an endophytic fungus associated with Xylopia aromatica显示文摘 | Teles H L Sordi R Silva G H Castro-Gamboa I Bolzani V S Pfen ing L H | 2006 | Phytochemistry2006，67，： | 1 |
| 15 | Purification, characterization and cDNA cloning of Kunitz - type proteinase inhibitor secreted by the porcine uterus 显示文摘 | STALI INGS - MANN M L BURKE M G TROUT W E | 1994 | J Biol Chem1994，269，24： | 1 |
| 16 | Fatigue capacity of FPSO structures显示文摘 | Pal G Bergan Inge Lotsberg | 2006 | Journal of Offshore Mechanics and Arctic Engineering2006，128，5： | 1 |
| 17 | Histological changes induced by dietary phospholipids in intestine and liver of common carp (Cyprinus carpio)larvae显示文摘 | Stephanie F Inge G Anne-Marie E | 1998 | Aquaculture1998，161，： | 1 |
| 18 | Comparison of different soybean phospholipidic fractions as dietary supplements for common Carp(Cyprinus carpio)larvae显示文摘 | Inge G Didier M Nicde C | 1998 | Aquaculture1998，161，： | 1 |
| 19 | Latent dirichlet allocation for spatial analysis of satellite images 显示文摘 | Corina V Inge G Mihai D | 2013 | Geoscience and Re- mote Sensing2013，51，5： | 1 |
| 20 | A Change Detection Experiment Using Vegetation Indices 显示文摘 | JOHN G L D ING YUAN ROSS S L | 1998 | Photogrammetric En- gineering & Remote Sensing1998，64，2： | 1 |
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