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| 1 | Future impact of integrated high-throughput methylome analyses on human health and disease显示文摘A spate of high-powered genome-wide association studies (GWAS) have recently identified numerous single-nucleotide polymor-phisms (SNPs) robustly linked with complex disease. Despite interrogating the majority of common human variation, these SNPs only account for a small proportion of the phenotypic variance, which suggests genetic factors are acting in concert with non-genetic factors. Although environmental measures are logical covariants for genotype-phenotype investigations, another non-genetic intermediary exists: epigenetics. Epigenetics is the analysis of somatically-acquired and, in some cases, transgenerationally inherited epigenetic modifications that regulate gene expression, and offers to bridge the gap between genetics and environment to understand phenotype. The most widely studied epigenetic mark is DNA methylation. Aberrant methylation at gene promoters is strongly implicated in disease etiology, most notably cancer. This review will highlight the importance of DNA methylation as an epigenetic regulator, outline techniques to character-ize the DNA methylome and present the idea of reverse phenotyping, where multiple layers of analysis are integrated at the individual level to create personalized digital phenotypes and, at a phenotype level, to identify novel molecular signatures of disease. | Lee M Butcher Stephan Beck | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 2 | Topography and edge effects are more important than elevation as drivers of vegetation patterns in a neotropical montane forest显示文摘 | Denis Lippok Stephan G. Beck Daniel Renison Isabell Hensen Amira E. Apaza Matthias Schleuning | 2014 | J Veg Sci2014，，3： | 1 |
| 3 | High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling — Results from a randomized, double-blind, and placebo-controlled study显示文摘 | Sandra Erbs Ephraim B. Beck Axel Linke Volker Adams Stephan Gielen Nicolle Kr?nkel Sven M?bius-Winkler Robert H?llriegel Holger Thiele Rainer Hambrecht Gerhard Schuler | 2010 | International Journal of Cardiology2010，，1： | 1 |
| 4 | A sharedscene-graph image-warping architecture for VR: Low latency versus image quality 显示文摘 | Ferdi Smit Robert van Liere Stephan Beck | 2010 | Computers & Graphics2010，34，1： | 1 |
| 5 | The methylome: approaches for global DNA methylation profiling显示文摘 | Stephan Beck Vardhman K. Rakyan | 2008 | Trends in Genetics2008，，5： | 1 |
| 6 | 面向3D呈现的有损和无损混合深度视频编码显示文摘针对多个深度视频流提出实时的压缩方法和评估方案,采用一种有损无损混合的编码方法,可以在图像质量和压缩率之间提供一种有效的平衡控制。行程编码(RLE)用于无损压缩,用来保存深度图像素的高位;像素低10bits保存在YUV图像的Y通道,直接使用×264编码。实验表明,所提方法可以在平均时间小于12ms的前提下同时编解码多个深度图。在实时传输中,通过动态调节质量控制级别,可以获取4∶1到20∶1的压缩率。在压缩率10∶1的情况下,主观解码3D重构效果与原始图几乎完全一致。 | 刘云鹏 Stephan Beck 王仁芳 王阳 郑文 Bemd Froehlich | 2017 | 光电子.激光2017，28，2： | 0 |
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