|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of NCPB and VSPL on pain and quality of life in chronic pancreatitis patients显示文摘AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain. | Andrzej Basinski Tomasz Stefaniak Ad Vingerhoets Wojciech Makarewicz Lukasz Kaska Aleksander Stanek Andrzej J.Lachinski Zbigniew Sledzinski | 2005 | World Journal of Gastroenterology2005，11，32： | 10 |
| 2 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 3 | Mechanisms of interleukin-22's beneficial effects in acutepancreatitis显示文摘Acute pancreatitis(AP) is a disorder characterized by parenchymal injury of the pancreas controlled by immune cell-mediated inflammation. AP remains a significant challenge in the clinic due to a lack of specific and effective treatment. Knowledge of the complex mechanisms that regulate the inflammatory response in AP is needed for the development of new approaches to treatment, since immune cell-derived inflammatory cytokines have been recognized to play critical roles in the pathogenesis of the disease. Recent studies have shown that interleukin(IL)-22, a cytokine secreted by leukocytes, when applied in the severe animal models of AP, protects against the inflammation-mediated acinar injury. In contrast, in a mild AP model, endogenous IL-22 has been found to be a predominantly antiinflammatory mediator that inhibits inflammatory cell infiltration via the induction of Reg3 proteins in acinar cells, but does not protect against acinar injury in the early stage of AP. However, constitutively over-expressed IL-22 can prevent the initial acinar injury caused by excessive autophagy through the induction of the antiautophagic proteins Bcl-2 and Bcl-XL. Thus IL-22 plays different roles in AP depending on the severity of the AP model. This review focuses on these recently reported findings for the purpose of better understanding IL-22's regulatory roles in AP which could help to develop a novel therapeutic strategy. | Chongmin Huan Daniel Kim Peiqi Ou Antonio Alfonso Albert Stanek | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 7 |
| 4 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 5 | An Upper and Lower Solution Theory for the Problem(G′(y))′+f(t,y)=0 on Finite and Infinite Intervals显示文摘A new upper and lower solution theory is presented for the second order problem(G'(y))'+f(t,y)=0 on finite and infinite intervals.The theory on finite intervals is based on a Leray-Schauderalternative,whereas the theory on infinite intervals is based on results on the finite interval and adiagonalization process. | Ravi P.AGARWAL Donal O'REGAN Svatoslav STANEK | 2006 | Acta Mathematica Sinica,English Series2006，22，3： | 2 |
| 6 | Botulinum neurotoxin A:A review显示文摘 | Berry MG Stanek JJ | 2012 | J Plast Reconstr Aesthet Surg2012，65，10： | 1 |
| 7 | Overfeeding macronutrients to critically ill adults:Metabolic complications显示文摘 | KLEIN C J STANEK G S WILES C E | 1998 | J Am Diet Assoc1998，98，： | 1 |
| 8 | The influence of the alite polymorphism on the strength of the Portland cement显示文摘 | STANEK T | 2002 | Cem Concr Res2002，32，7： | 1 |
| 9 | Diferential localization of heat shock ptotein 90,70,60 and 27 in human decid- uas and placenta during pregnancy显示文摘 | Shah M Stanek J Handwerger S | 1998 | Histochem J1998，30，7： | 1 |
| 10 | Barriers associated with the failure to return for intrauterine device insertion following first - trimester abortion 显示文摘 | Stanek AM Bednarek PH Niehols MD | 2009 | Contraception2009，79，3： | 1 |
| 11 | Development of LuAG-based scintillator crystals – A review显示文摘 | M. Nikl A. Yoshikawa K. Kamada K. Nejezchleb C.R. Stanek J.A. Mares K. Blazek | 2013 | Progress in Crystal Growth and Characterization of Materials2013，，： | 1 |
| 12 | Nonstoichiometry in A2B2O7 pyrochlores 显示文摘 | Stanek C R Minervini L Grimes R W | 2002 | Journal of American Ceramic society2002，85，11： | 1 |
| 13 | Prognostic evaluation of neurohumoral plasma levels before and during B-blocker therapy in advanced left ventricular dysfunction显示文摘 | Stanek B Frey B Hulsmann M | 2001 | J Am Coll Cardiol2001，38，2： | 1 |
| 14 | Determination of thermal diffusivity and thermal conductivity of Mg-A1 alloys 显示文摘 | Rudajevova A Stanek M Lukac P | 2003 | Materials Science and Engineering A2003，341，： | 1 |
| 15 | Evidence that healthy human gingi- va contains functionally heterogeneous fibmblast subpopulations 显示文摘 | Hassell TM Stanek EJ 3rd | 1983 | Arch Oral Biol1983，28，7： | 1 |
| 16 | Value of eardiopulmonary exercise testing and big endothelin plasma levels to predict short- term prognosis of patients with chronic heart failure 显示文摘 | Hulsmann M Stanek B Frey B | 1998 | J Am Coll Cardiol1998，32，6： | 1 |
| 17 | Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure显示文摘 | Pacher R Stanek B Hulsmann M | 1996 | J Am Coll Cardiol1996，27，3： | 1 |
| 18 | Resolving intertracer in consistencies in soil ingestion estimation显示文摘 | Stanek EJ | 1995 | Environ Health Perspect1995，103，： | 1 |
| 19 | Separation of aromatic sul- phonic acid dye intermediates by high-performance liquid chromatography and capillary zone electrophoresis 显示文摘 | Jandera P Fischer J Stanek V | 1996 | Journal of Chromatography A1996，738，2： | 1 |
| 20 | Acquisition and Retention of lead by young children显示文摘 | Manton WI Angle CR Stanek KL | 2000 | Environ Res2000，82，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员