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| 1 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 2 | Extra Corporeal Membrane Oxygenationas Right Heart Support Following Left Ventricular Assist Device Placement:A New Cannulation Technique显示文摘 | De Silva RJ Soto C Spratt P | 2012 | Heart Lung Circ2012，21，4： | 1 |
| 3 | Collaborative Action Learning:a Professional Development Model for Educational Innovation in Nursing显示文摘 | Marlow A Spratt C Reilly A | 2008 | Nurse Education in Practice2008，8，3： | 1 |
| 4 | Fuzzy species among recombinogenic bacteria显示文摘 | Hanage WP Fraser C Spratt BG | 2005 | BMC Biology2005，3，： | 1 |
| 5 | Optic disc and visual field changes after trabeculectomy显示文摘 | Kotecha A Spratt A Bunce C | 2009 | Invest Ophthalmol Vis Sci2009，50，10： | 1 |
| 6 | Perfusion computer tomography:imaging and clinical validation in acute ischaemic stroke显示文摘 | BIVARD A SPRATT N LEVI C | 2011 | Brain2011，134，11： | 1 |
| 7 | Plaque stabilisation by systemic and local drug administration显示文摘 | Spratt J C Eamenzined E | 2004 | Heart2004，90，12： | 1 |
| 8 | Fuzzy species among recombinogenic bacteria显示文摘 | Hanage WP Fraser C Spratt BG | 2005 | BMC Biology2005，3，： | 1 |
| 9 | Perfusion computer tomography:imaging and clinical validation in acute ischaemic stroke显示文摘 | Bivard A Spratt N Levi C | 2011 | Brain2011，134，11： | 1 |
| 10 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 11 | A prospective study of pre- dictors of prolonged hospital stay and disability after stroke 显示文摘 | Spratt N Wang Y Levi C | 2003 | J Clin Neurosci2003，10，6： | 1 |
| 12 | Perfusion CT in acute stroke:a comprehensive analysis of infarct and penumbra显示文摘 | BIVARD A LEVI C SPRATT N | 2013 | Radiology2013，267，2： | 1 |
| 13 | A prospective study of predictors of prolonged hospital stay and disability after stroke 显示文摘 | Spratt N Wang Y Levi C | 2003 | J Clin Neurosci2003，10，： | 1 |
| 14 | The perceptions of undergraduate student nurses of high-fidelity simulation-based learning: A case report from the University of Tasmania 显示文摘 | Reilly A Spratt C | 2007 | Nurse Education Today2007，27，6： | 1 |
| 15 | A prospective study of predictors of prolonged hospital stay and disability after stroke 显示文摘 | Spratt N Wang Y Levi C | 2003 | J Clin Neurosci2003，10，6： | 1 |
| 16 | Localized sex in bacteria显示文摘 | Dowson C G Spratt B G | 1991 | Nature1991，349，： | 1 |
| 17 | Large birmedial rectus recessions in congenital esotropia 显示文摘 | Szmyd SM Nelson LB Calhoun JH Spratt C | 1985 | Br J Ophthalmol1985，69，4： | 1 |
| 18 | A high efficiency membrane oxygenator and pulsatile pumping system, and its application to animal trials显示文摘 | Bellhouse B J Bellhouse F H Curl C M MacMillan T I Gunning A J Spratt E H MacMurray S B Nelems J M | 1973 | ASA/O Journal1973，19，1： | 1 |
| 19 | Harmonic imaging improves estimation of left ventricular mass 显示文摘 | Spratt J C Leslie S J White A | 2004 | Int J Cardiovasc Imaging2004，20，2： | 1 |
| 20 | 流行病学和临床研究中数据缺失的多重填补:机会和陷阱显示文摘许多研究都存在缺失数据。Jonathan | Jonathan A C Sterne Ian R White John B Carlin Michael Spratt Patrick Royston Michael G Kenward Angela M Wood James R Carpenter 张清(译) 张孔来(校) | 2009 | 英国医学杂志中文版2009，12，6： | 1 |
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