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274篇 您的检索式：作者名="Sponsel"

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	题名	作者	年代	出处	被引量
1	Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.	Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao	2017	Bone Research2017，5，1：	9
2	The trapdoor procedure using autogenous cortical and cancellous bone grafts for osteonecrosis of the femoral head 显示文摘	Mont MA Einhorn TA Sponseller PD	1998	J Bone and Joint Surg1998，80，：	1
3	The surgical managementof pediatric fractures of the lower extremeity 显示文摘	Flymn JM Skaggs D Sponseller PD	2003	Instr Course Lect2003，52，：	1
4	Infection Rate after Spine Surgery in Cerebral Palsy is High and Impairs Results: Multicenter Analysis of Risk Factors and Treatment显示文摘	Paul D. Sponseller Suken A. Shah Mark F. Abel Peter O. Newton Lynn Letko Michelle Marks	2010	Clinical Orthopaedics and Related Research?2010，，3：	1
5	Effect of high-dose pitavastatin on glucose homeostasis in patients at elevated risk of new-onset diabetes: insights from the CAPITAIN and PREVAIL-US studies显示文摘	M. J. Chapman A. Orsoni P. Robillard N. Hounslow C.A. Sponseller P. Giral	2014	Current Medical Research & Opinion2014，，5：	1
6	Skeletal involvement in children who have chronic granulomatous disease显示文摘	Sponseller PD Malech HL Mccarthy EJ	1991	J Bone Joint Surg Am1991，73，：	1
7	The acetabulum in congenital and neuromuscular hip instability显示文摘	Buckly SL Sponseller PD Magid D	1991	J Pediatr Orthop1991，11，4：	1
8	Results of brace treatment of scoliosis in Marfan syndrome显示文摘	Sponseller PD Bhimani M Solacoff D	2000	Spine2000，25，18：	1
9	Precipitation pulses and soil CO2flux in a Sonoran Desert ecosystem显示文摘	Sponseller R A	2008	Global Change Biology2008，13，42：	1
10	Infantile scoliosis in Marfan syndrome显示文摘	Sponseller PD Sethi N Cameron DE	1997	Spine1997，22，5：	1
11	The trapdoor procedure using autogenous cortical and cancellous bone grafts for osteonecrosis of the femoral head 显示文摘	Mont MA Einhorn TA Sponseller PD	1998	J Bone Joint Surg Br1998，80，1：	1
12	Clinical improvement in patients with decompensated liver disease caused by hepatitis B after treatment with lamivudine显示文摘	Craig A Sponseller A Bruce R	2000	Liver Transplant2000，6，6：	1
13	Precipitation pulses and soil CO2 flux in a Sonoran Desert ecosystem显示文摘	Sponseller R A	2007	Global Change Biology2007，13，2：	1
14	Scoliosis surgery in cerebral palsy: differences between unit rod and custom rods显示文摘	Sponseller PD Shah SA Abel MF	2009	Spine2009，34，8：	1
15	The Acetabulum in congenital and neuromuscular hip instability显示文摘	Buckley SL Sponseller PD	1991	J Pediatric Orthop1991，11，：	1
16	Growing rod frac-tures:risk factors and opportunities for prevention显示文摘	Yang JS Sponseller PD Thompson GH	2011	Spine(Phila Pa 1976)2011，36，20：	1
17	Comparison of dynamic versus static external fixation for pediatric femur fractures显示文摘	Domb BG Sponseller PD Ain M	2002	J Pediatr Orthop2002，22，4：	1
18	Spine deformity correction in Marfan syndrome显示文摘	Jones K B Erkula G Sponseller P D	2002	Spine2002，27，18：	1
19	Spine deformity correction in Marfan syndrome显示文摘	Jones KB ErkulaG Sponseller PD	2002	Spine2002，27，18：	1
20	Vertebral Column Resection in Children with Neuromuscular Spine Deformity显示文摘	Sponseller PD Jain A Lenke LG		0，，1976：	1

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