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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Precipitation pulses and soil CO2flux in a Sonoran Desert ecosystem显示文摘 | Sponseller R A | 2008 | Global Change Biology2008，13，42： | 1 |
| 3 | Clinical improvement in patients with decompensated liver disease caused by hepatitis B after treatment with lamivudine显示文摘 | Craig A Sponseller A Bruce R | 2000 | Liver Transplant2000，6，6： | 1 |
| 4 | Precipitation pulses and soil CO2 flux in a Sonoran Desert ecosystem显示文摘 | Sponseller R A | 2007 | Global Change Biology2007，13，2： | 1 |
| 5 | Vertebral Column Resection in Children with Neuromuscular Spine Deformity显示文摘 | Sponseller PD Jain A Lenke LG | | 0，，1976： | 1 |
| 6 | Clinical improvement in patients with decompensated liver disease caused hepatitis B after treatment with lamivudine显示文摘 | Sponseller C A Baconn B R Bisceglie A M | 2000 | Liver Transplogy2000，6，： | 1 |
| 7 | Are antifibrinolytics helpful in decreasing blood loss and transfusions during spinal fusionsurgery in children with cerebral palsy scoliosis? 显示文摘 | DHAWALE A A SHAH S A SPONSELLER P D | 2012 | Spine2012，37，9： | 1 |
| 8 | The trapdoor procedure using autogenous cortical and cancellous bone grafts for osteonecrosis of the femoral head显示文摘 | Mont M A Einhorn T A Sponseller P D | 1998 | J Bone Joint Surg Br1998，80，1： | 1 |
| 9 | Precipitation pulses and soil CO2flux in a Sonoran Desert ecosystem显示文摘 | Sponseller R A | 2007 | Global Change Biology2007，13，2： | 1 |
| 10 | Influenza A pandemic (HIN1) 2009 virus infection in domestic cat 显示文摘 | Sponseller B A Strait E Jergens A | 2010 | Emerg Infect Dis2010，16，： | 1 |
| 11 | Atlantoaxial rotaory subluxation in patients with Marfan syndrome 显示文摘 | Herzka A Sponseller PD Pueritz RE | 2000 | Spine2000，25，4： | 1 |
| 12 | Influenza A pandemic (H1N1) 2009 virus infection in domestic cat 显示文摘 | Sponseller BA Strait E Jergens A | 2009 | Emerg infect Dis2009，16，： | 1 |
| 13 | Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy显示文摘 | Sponsel WE Paris G Trigo Y Pena M Weber A Sanford K | 2002 | Am J Ophthalmol2002，133，1： | 1 |
| 14 | Does patient diagnosis predict blood loss during posterior spinal fusion in children? 显示文摘 | Jain A Njoku DB Sponseller PD | 2012 | Spine ( Phila Pa 1976)2012，37，19： | 1 |
| 15 | Pelvic fixation in spine surgery:historical overview,indications,biomechanical relevance,and current techniques显示文摘 | Moshirfar A Rand FF Sponseller PD | 2005 | J Bone Joint Surg Am2005，87，2： | 1 |
| 16 | Atlantoaxial rotatory subluxation in patients with Marfan syndrome显示文摘 | Herzka A Sponseller P D Pueritz R E | 2000 | Spine2000，25，4： | 1 |
| 17 | Influenza A pan demic (H1N1)2009 virus Infection in domestic cat显示文摘 | Sponseller B A Strait E Jergcns A | 2010 | Emerg Infect Dis2010，16，3： | 1 |
| 18 | Relationships between land use, spatial scale and stream macroinvertehrate communities 显示文摘 | Sponseller R A Benfield E F Valett H M | 2001 | Freshwater Biology2001，46，10： | 1 |
| 19 | Precipitation pulses and soil CO2 flux in a Sonoran Desert ecosystem显示文摘 | Sponseller R A | 2007 | Global Change Biology2007，13，2： | 1 |
| 20 | The trapdoor procedure using autogenous cortical and cancellous bone grafts for osteonecrosis of the femoral head显示文摘 | MONT M A EINHORN T A SPONSELLER P D | 1998 | J Bone Joint Surg Br1998，80，1： | 1 |
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