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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | The gender and ethnic diversity of US boards and board committees and firm financial performance 显示文摘 | Carter D A D ' Souza F Simkins B J Simpson W G | 2010 | Corporate Governance:An International Review2010，18，5： | 1 |
| 4 | Collaboration and competition between 4PL and 3PL a study of a fast-food supply chain显示文摘 | Vivaldini M Pires S P T Souza F B | 2008 | Journal of Operations and Supply Chain Management2008，1，1： | 1 |
| 5 | Marine macro-alga sargassum cymosum as electron donor for hexavalent chromium reduction to trivalent state in aqueous solutions显示文摘 | SOUZA F B D BRANDAO H D L HACKBARTH F V | 2015 | Chemical Engineering Journal2015，，： | 1 |
| 6 | Characterization and kinetic compensation effect of corn biodiesel显示文摘 | DANTAS M B ALMEIDA A A F CONCEICAO M M FERNANDES V J Jr SANTOS I M G SILVA F C SOLEDADE L F B SOUZA A G | 2007 | J Therm Anal Calorim2007，87，3： | 1 |
| 7 | Nickel-catalyzed propylene dimerization in organochloroaluminate ionic liq uids: control of the isomerization reaction显示文摘 | SOUZA R F D LEAL B C MO D S | 2007 | J Mol Catal A: Chem2007，272，12： | 1 |
| 8 | Long-term safety and tolerabilityof oxcarbazepine in children : a review of clinical experience显示文摘 | BOURGEOIS B F D5 SOUZA J | 2005 | Epilepsy Behav2005，7，3： | 1 |
| 9 | Characterization of Pd-CeO2 interaction on alumina support and hydrogenation of 1,3-butadiene 显示文摘 | Schmal M De Souza Monteiro R Noronha F B Dieguez L C | 1995 | Appl Catal A1995，131，： | 1 |
| 10 | Influence of 17a, 20fl-dihydroxy-4-pregnen-3-one injected into a post-ovulatory female on the reproductive behavior of male Nile tilapia (Oreochromis niloticus)显示文摘 | de Souza S M G Lucion A B Wassermann G F | 1998 | Comp Biochem Physiol A-Mol Integr Physiol1998，119，3： | 1 |
| 11 | Isolation of a starch utilizing, phosphate solubilizing fungus on buffered medium and its characterization显示文摘 | Ahuja A Ghosh S B D Souza S F | 2007 | Bioresource Technology2007，98，17： | 1 |
| 12 | Evaluation of the zinox and zeolite materials as adsorbents to remove H2S from natural gas显示文摘 | MELO D M A SOUZA J R MELO M A F MARTINELLI A E CACHIMA G H B CUNHA J D | 2006 | Colloid Surface A2006，272，12： | 1 |
| 13 | Compliance with hepatitis B virus vaccination and risk of occupational exposure to blood and other body fluids in intensive care department personnel in Brazil显示文摘 | Vania F.C Manso Kézia F Castro Sirley M Matos Ana Luiza N Junqueira Sandra B Souza Márcia M Sousa Regina M.B Martins Sheila A Teles | 2003 | AJIC: American Journal of Infection Control2003，，7： | 1 |
| 14 | Effects of the fault inception angle in fault-induced transients显示文摘 | COSTA F B SOUZA B A BRITO N S D | 2012 | IET Generation Transmission&Distribution2012，6，5： | 1 |
| 15 | Impact of atmosphere; organic acids, and calcium: on quality of fresh-cut 'ensington' mango显示文摘 | de Souza B S OHare T J Durigan J F etal | 2006 | Postharvest Biology and Technology2006，42，2： | 1 |
| 16 | Influence of 17α, 20β-dihydroxy-4-pregnen-3-one injected into a post-ovulatory female on the reproductive behavior of male nile Tilapia(oreochromis niloticus)显示文摘 | Souza S M G Lucion A B Wassermann G F | 1998 | Comparative Biochemistry and Physiology1998，119，3： | 1 |
| 17 | Denitrification of highly alkaline nitrate waste using adapted sludge 显示文摘 | Dhamole P B Nair R R D'Souza S F | 2008 | Applied Biochemistry and Biotechnology2008，151，23： | 1 |
| 18 | Structural model proposition and thermodynamic and vibrational analysis of hydrotalcite-like compounds by dft calculations显示文摘 | COSTA D G ROCHA A B DINIZ R SOUZA W F CHIARO S S X LEIT?O A A | | 0，，33： | 1 |
| 19 | Comparative structural,thermodynamic and electronic analyses of ZnAIAn-hydrotalcite-like compounds (An-CI-,F-,Br-,OH-,CO32-or NO3):An ab initio study显示文摘 | COSTA D G ROCHA A B SOUZA W F CHIARO S S X LEITA O A A | | 0，，： | 1 |
| 20 | Isolation of nanocellulose from pineapple leaf fibres by steam explosion 显示文摘 | Cherian B M LeZio A L de Souza S F | 2010 | Carbohydrate Polymers2010，81，3： | 1 |
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