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| 1 | Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia显示文摘AIM To study liver stiffness(LS) during pregnancy and its association with complications during pregnancy.METHODS In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device(Echosens, Paris) in all women and in 41 cases 24 h after delivery. Clinical and morphological data were recorded and abdominal ultrasound and standard laboratory tests were performed. No complications were observed in 475 women(controls) while preeclampsia and intrahepatic cholestasis of pregnancy(ICP) developed in 22 and 40 women, respectively.RESULTS In controls, LS increased significantly from initially 4.5 ± 1.2 kPa in the second trimester to 6.0 ± 2.3 kPa(P < 0.001) in the third trimester. In the third trimester, 41% of women had a LS higher than 6 kPa. Elevated LS in controls was significantly correlated with alkaline phosphatase, leukocytes, gestational age and an increase in body weight and body mass index(BMI). In women with pregnancy complications, LS was significantly higher as compared to controls(P < 0.0001). Moreover, in multivariate analysis, LS was an independent predictor for preeclampsia with an odds ratio of 2.05(1.27-3.31) and a cut-off value of 7.6 kPa. In contrast, ICP could not be predicted by LS. Finally, LS rapidly decreased in all women within 24 h after delivery from 7.2 ± 3.3 kPa down to 4.9 ± 2.2 kPa(P < 0.001).CONCLUSION During pregnancy, LS significantly and reversibly increases in the final trimester of pregnant women without complications. In women with preeclampsia, LS is significantly elevated and an independent noninvasive predictor. | Franziska J Ammon Anna Kohlhaas Omar Elshaarawy Johannes Mueller Thomas Bruckner Christof Sohn Gabriele Fluhr Herbert Fluhr Sebastian Mueller | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 2 | Transformation of wheat with the gene encoding the coat protein of barley yellow mosaic virus显示文摘 | Karunaratne S Sohn A Mouradov A Scott J Steinbi H Scott K J | 1996 | Aust J Plant Physiol1996，23，： | 2 |
| 3 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 4 | Acid catalysis by dealuminated zeolite-Y I Methanol dehydration and cumene dealkylation显示文摘 | DECANIO S J SOHN J R FRITZ P O | 1986 | Journal of Catalysis1986，101，1： | 1 |
| 5 | Isoperimetric numbers of graph bundles 显示文摘 | Kwak J H Lee J Sohn M Y | 1996 | Graphs and Combinatorics1996，12，3： | 1 |
| 6 | Evaluating the significance of highway network links under the flood damage: An accessibility approach 显示文摘 | Sohn J | 2005 | Transportation Research A2005，，40： | 1 |
| 7 | Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU)显示文摘 | JHA P SOHN J H XU Q | 2006 | J Immunol2006，176，12： | 1 |
| 8 | Structural health monitoring using statistical process control 显示文摘 | Sohn H Czarneeki J A Farrar C R | 2000 | Journal of Structural Engineering2000，126，11： | 1 |
| 9 | Solvent-free bentonite-catalyzed condensation of malonic acid and aromatic aldehydes under microwave irradiation显示文摘 | Loupy A Song S J Sohn S M | 2001 | J Chem Soc Perkin Trans 12001，10，： | 1 |
| 10 | Adoption of nano-materials for the micro-layer in gas diffusion layers of PEMFCs显示文摘 | Park G G Sohn Y J Yim S D | 2006 | J Power Sources2006，163，1： | 1 |
| 11 | Electrochemical impedance analysis for lithium ion intercalation into graphitized carbons显示文摘 | CHANG Y C SOHN H J | 2000 | J Electrochern Soc2000，147，1： | 1 |
| 12 | Nanosized Sn-Cu-B alloy anode prepared by chemical reduction for secondary lithium batteries 显示文摘 | KIM D G KIM H SOHN H J | 2002 | J Power Sources2002，104，2： | 1 |
| 13 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 14 | Lipophilic stinging nettle extracts possess potent anti-inflammatory activity,are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders显示文摘 | Johnson T A Sohn J Inman W D | 2013 | Phytomedicine2013，20，2： | 1 |
| 15 | Do preoperative biliary stents increase postpancreaticoduodenectomy complicatioas?显示文摘 | SOHN TA YEO C J CAMERON JL | 2000 | J Gastrointest Surg2000，4，4： | 1 |
| 16 | Six hundred filly consecutive panereaticoduodenectomies in the 1990s: Pathology complication, and outcomes显示文摘 | Yeo C J Cameron JL Sohn TA | 1997 | Ann Surg1997，226，3： | 1 |
| 17 | A statistical model-based voice activity detection显示文摘 | Sohn J Kim N S Sung W | 1999 | IEEE Signal Process1999，16，： | 1 |
| 18 | Comparing MR imaging and CT in the staging of gastric carcinoma显示文摘 | Sohn K M Lee J M Lee S Y | 2000 | AJR2000，174，6： | 1 |
| 19 | Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications,and outcomes 显示文摘 | Yeo C J Cameron JL Sohn TA | 1997 | Aun Surg1997，226，3： | 1 |
| 20 | Postweaning dietary folate deficiency provided through childhood to puberty permanently increases genomic DNA methylation in adult rat liver显示文摘 | KOTSOPOULOS J SOHN K J KIM Y I | 2008 | J Nutr2008，138，： | 1 |
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