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| 1 | Mucosal healing in inflammatory bowel disease: Maintain orde-escalate therapy显示文摘In the past decade, thanks to the introduction of biologic therapies, a new therapeutic goal, mucosal healing(MH), has been introduced. MH is the expression of an arrest of disease progression, resulting in minor hospitalizations, surgeries, and prolonged clinical remission. MH may be achieved with several therapeutic strategies reaching success rates up to 80% for both, ulcerative colitis(UC) and Crohn's disease(CD). Various scoring systems for UC and for the transmural CD, have been proposed to standardize the definition of MH. Several attempts have been undertaken to de-escalate therapy once MH is achieved, thus, reducing the risk of adverse events. In this review, we analysed the available studies regarding the achievement of MH and the subsequent treatment de-escalation according to disease type and administered therapy, together with non-invasive markers proposed as predictors for relapse. The available data are not encouraging since de-escalation after the achievement of MH is followed by a high number of clinical relapses reaching up to 50% within one year. Unclear is also another question, in case of combination therapies, which drug is more appropriate to stop, in order to guarantee a durable remission. Predictors of unfavourable outcome such as disease extension, perianal disease, or early onset disease appear to be inadequate to foresee behaviour of disease. Further studies are warranted to investigate the role of histologic healing for the further course of disease. | Marcello Cintolo Giuseppe Costantino Socrate Pallio Walter Fries | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 6 |
| 2 | Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer:Quo vadis?显示文摘Breast cancer(BC) is the most frequent type of non skin cancer among women and a major leading cause of cancer-related deaths in Western countries. It is substantial to discover novel biomarkers with diagnostic, prognostic or predictive usefulness as well as therapeutic value for BC. Micro-RNAs(miR NAs) belong to a novel class of endogenous interfering RNAs that play a crucial role in post transcriptional gene silencing through m RNA targeting and, thus, are involved in many biological processes encompassing apoptosis,cell-cycle control, cell proliferation, DNA repair, immunity, metabolism, stress, aging, etc. Mi RNAs exert their action mainly in a tumor suppressive or oncogenic manner. The specific aberrant expression patterns of miR NAs in BC that are detected with the use of highthroughput technologies reflect their key role in cancer initiation, progression, migration, invasion and metastasis. The detection of circulating extracellular miR NAs in plasma of BC patients may provide novel, non-invasive biomarkers in favor of BC diagnosis and prognosis and,at the same time, accumulating evidence has underscored the possible contribution of miR NAs as valuable biomarkers to predict response to chemotherapy or radiotherapy. Data from in vitro and in vivo studies on BC have revealed promising therapeutic approaches via mi RNA delivery and mi RNA inhibition. The purpose of this review is to explore the ontological role of miR NAs in BC etiopathogenesis as well as to highlight their potential, not only as non-invasive circulating biomarkers with diagnostic and prognostic significance, but also as treatment response predictors and therapeutic targets aiding BC management. | Gerasimos Socrates Christodoulatos Maria Dalamaga | 2014 | World Journal of Clinical Oncology2014，5，2： | 4 |
| 3 | Efficacy and safety of endoscopic papillary balloon dilation for the removal of bile duct stones: Data from a “real-life” multicenter study on Dilation-Assisted Stone Extraction显示文摘AIM To report data on Dilation-Assisted Stone Extraction(DASE) use in clinical practice and its efficacy and safety trough three Italian referral centers for biliopancreatic diseases treatment. METHODS From January 2011 to December 2015 we collected data on 120 patients treated with DASE. Technical success was obtained when the endoscopist was able to place the balloon trough the papilla inflating the balloon until the final diameter for an adequate time(at least 30 s). Clinical success was obtained after complete stone removal(no remaining stones were visible at the cholangiogram).RESULTS Forty-nine male(40.8%) and 71 female(59%) were enrolled. The mean age was 67.8 years ± 15.7. The mean common bile duct(CBD) dilation was 19.2 mm± 3.9 and the mean size of stones 15.8 ± 2.9. DASE was applied as first approach in 38%(62% after initial failure of stones extraction). Technical and clinical success was of 91% and 87% respectively. In those in which DASE failed alternative treatment were adopted. After DASE 18% of patients experienced a complication(bleeding 9%, pancreatitis 8%, perforation 0.8%). At univariable analysis, elective endoscopic retrograde cholangiopancreatography(P = 0.031), DASE as first approach(P = 0.032), and cannulation of major papilla followed by guidewire insertion(P = 0.004) were related to low risk of complications. Pre-cut was related to an increased risk of complications(P = 0.01). CONCLUSION DASE allowed a higher first-session success rate and can be consider a valid alternative to endoscopic sphincterotomy not only for bigger CBD stones. | Roberto Di Mitri Filippo Mocciaro Socrate Pallio Giulia Maria Pecoraro Andrea Tortora Claudio Zulli Simona Attardo Attilio Maurano | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 4 | Endoscopic ultrasound-guided ethanol ablation ofpancreatic neuroendocrine tumours:A case study andliterature review显示文摘Here we offer a review of the literature regarding endoscopic ultrasound-guided ethanol ablation for pancreatic neuroendocrine tumours and describe the case of a cystic tumour completely ablated after a multisession procedure. A total of 35 PubM ed indexed cases of treated functioning and non-functioning pancreatic neuroendocrine tumours resulted from our search, 29 of which are well-documented and summarised. Endoscopic ultrasound-guided ethanol ablation appears as a local, minimally invasive treatment of pancreatic neuroendocrine tumours, suitable for selected patients. This technique appears feasible, relatively safe and efficient, especially when applied to symptom relief in functioning tumours, aiming at loss of endocrine secretion. For non-functioning tumours, where the goal is complete tissue ablation, eus guided ethanol ablation can provide good results for patients who are unfit for surgery or for those who refuse surgical resection. Its role in 'fit for surgery' patients requires assessment through further studies. | Elia Armellini Stefano F Crinò Marco Ballarè Socrate Pallio Pietro Occhipinti | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 3 |
| 5 | Novel endoscopic management for pancreatic pseudocyst with fistula to the common bile duct显示文摘Pancreatic pseudocyst formation is a well-known complication of pancreatitis. It represents about 75% of the cystic lesions of the pancreas and might be located within or surrounding the pancreatic tissue. Sixty percent of the occurrences resolve spontaneously and only persistent, symptomatic or complicated cysts need to be treated. Complications include infection, hemorrhage, gastric outlet obstruction, splenic infarction and rupture. The formation of fistulas to other viscera is rare and most commonly occurs within the stomach, duodenum or colon. We report a case of a patient with a pancreatic pseudocyst in communication with the common bile duct. There have been only few cases reported in the literature. We successfully managed our case by performing an endoscopicultrasound-guided drainage of the pancreatic collection and a contemporaneous stenting of the common bile duct. Performed independently, both drainages are effective, safe and well-coded and the expertise on these procedures is widespread. By our knowledge this therapeutic approach was never reported in literature but we retain this is the most correct treatment for this very rare condition. | Stefano Francesco Crinò Giuseppe Scalisi Pierluigi Consolo Doriana Varvara Antonio Bottari Sebastiano Pantè Socrate Pallio | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 3 |
| 6 | Depression, Anxiety and Anger in Subtypes of Irritable Bowel Syndrome Patients显示文摘 | Maria Rosaria A. Muscatello Antonio Bruno Gianluca Pandolfo Umberto Micò Simona Stilo Mariagrazia Scaffidi Pierluigi Consolo Andrea Tortora Socrate Pallio Giuseppa Giacobbe Luigi Familiari Rocco Zoccali | 2010 | Journal of Clinical Psychology in Medical Settings2010，，1： | 2 |
| 7 | A continuum constitutive model for the mechanical behavior of woven fabrics显示文摘 | M.J. King P. Jearanaisilawong S. Socrate | 2004 | International Journal of Solids and Structures2004，，13： | 2 |
| 8 | Use of ketamine sedation for the management of displaced paediatric forearm fractures显示文摘AIM To determine if ketamine sedation is a safe and cost effective way of treating displaced paediatric radial and ulna fractures in the emergency department. METHODS Following an agreed interdepartmental protocol, fractures of the radius and ulna(moderately to severely displaced) in children between the age of 2 and 16 years old, presenting within a specified 4 mo period, were manipulated in our paediatric emergency department. Verbal and written consent was obtained prior to procedural sedation to ensure parents were informed and satisfied to have ketamine. A single attempt at manipulation was performed. Pre and postmanipulation radiographs were requested and assessed to ensure adequacy of reduction. Parental satisfaction surveys were collected after the procedure to assess the perceived quality of treatment. After closed reduction and cast immobilisation, patients were then followed-up in the paediatric outpatient fracture clinic and functional outcomes measured prospectively. A cost analysis compared to more formal manipulation under a general anaesthetic was also undertaken.RESULTS During the 4 mo period of study, 10 closed, moderate to severely displaced fractures were identified and treated in the paediatric emergency department using our ketamine sedation protocol. These included fractures of the growth plate(3), fractures of both radius and ulna(6) and a single isolated proximal radius fracture. The mean time from administration of ketamine until completion of the moulded plaster was 20 min. The mean time interval from sedation to full recovery was 74 min. We had no cases of unacceptable fracture reduction and no patients required any further manipulation, either in fracture clinic or under a more formal general anaesthetic. There were no serious adverse events in relation to the use of ketamine. Parents, patients and clinicians reported extremely favourable outcomes using this technique. Furthermore, compared to using a manipulation under general anaesthesia, each case performed under ketamine sedation was associated with a saving of ￡1470, the overall study saving being ￡14700. CONCLUSION Ketamine procedural sedation in the paediatric population is a safe and cost effective method for the treatment of displaced fractures of the radius and ulna, with high parent satisfaction rates. | Anatole Vilhelm Wiik Poonam Patel Joanna Bovis Adele Cowper Philip Socrates Pastides Alison Hulme Stuart Evans Charles Stewart | 2018 | World Journal of Orthopedics2018，9，3： | 2 |
| 9 | The study and performance of a modified conventional refrigerator to serve as a PV powered one显示文摘 | Socrates Kaplanis Nikolaos Papanastasiou | | 0，，06： | 1 |
| 10 | Internalisation of external cost in the power generation sector:analysis with global multi regional markal model显示文摘 | RAFAJ Peter KYPREOS Socrates | | 0，，02： | 1 |
| 11 | Extending the internet of things to the future internet through IPv6 support显示文摘 | Antonio J Jara Socrates Varakliotis Antonio F Skarmeta Peter Kirstein | 2014 | Mobile Information Systems2014，10，1： | 1 |
| 12 | Popliteal aneurysms: current management and outcome 显示文摘 | Locati P Socrate AM Costantini E | 1999 | Minerva Cardioangiol1999，47，5： | 1 |
| 13 | Orphanoudakis, A multi - agent platform for content - based image retrieval 显示文摘 | Socrates Dimitriadis Kostas Marias Stelios C | 2007 | Multimed Tools Appl2007，，33： | 1 |
| 14 | Sympathetic activa- tion in chronic renal failure显示文摘 | Schlaich MP Socratous F Hennebry S | 2009 | JASN2009，20，： | 1 |
| 15 | Recovy of Power output and Heart Rate Kinetic During Repeated Bouts of Rowing Exercise with Different Rest Intervals显示文摘 | Evangelia M Gregory CB Socrates K | | 0，，05： | 1 |
| 16 | A micromechanical model for multiple crazing in high impact polystyrene 显示文摘 | Socrate S Boyce M C Lazzeri A | 2001 | Mechanics of Materials2001，33，： | 1 |
| 17 | Numerical determination of the elastic driving force for directional coarsening in Ni-superalloys显示文摘 | SOCRATE S PARKS D M | 1993 | Acta Metallurgica et Materialia1993，41，7： | 1 |
| 18 | The study and performance of a mo- dified conventional refiigerator to serve as a PV powered one显示文摘 | SOCRATES K NIKOLAOS P | 2006 | Re- newable Energy2006，31，6： | 1 |
| 19 | Arachidonic acid promotes migration and invasion through a PI3K/Akt-dependent pathway in MDA-MB-231 breast cancer cells显示文摘 | Socrates Villegas-Comonfort Rocio Castillo-Sanchez Nathalia Serna-Marquez Pedro Cortes-Reynosa Eduardo Perez Salazar | 2014 | Prostaglandins Leukotrienes and Essential Fatty Acids (PLEFA)2014，，： | 1 |
| 20 | Numerical determination of the elastic driving force for directional coarsening in Ni-superalloys显示文摘 | SOCRATE S PARKS D M | 1993 | Acta Metall Mater1993，41，： | 1 |
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