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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | Prevention of ventilator - associatedpneumonia显示文摘 | Lau AC So HM Tang SL | 2015 | Hong Kong Med J2015，21，1： | 1 |
| 3 | Perioperative transient ischemic at- tack caused by the cessation of warfarin 显示文摘 | Lee SO Li MJ Ho HM | 2010 | Acta Anaesthesiol Taiwan2010，48，4： | 1 |
| 4 | Carbachol regulates pacemaker activities in cultured interstitial cells of Cajal from the mouse small intestine显示文摘 | So KY Kim SH Sohn HM | 2009 | Mol Cells2009，27，5： | 1 |
| 5 | Detection and titer estimation of Escherichia coli using aptamer-functionalized single-walled car-bon-nanotube field-effect transistors显示文摘 | So HM Park DW Jeon EK | 2008 | Small2008，4，2： | 1 |
| 6 | Systemic car- diovascular complications in patients with long - standing diabetes mellitus:Comprehensive assessment with whole- body magnetic resonance imaging/magnetic resonance angiography显示文摘 | Weckbaeh S Findeisen HM Schoenberg SO | 2009 | Invest Radiol2009，44，4： | 1 |
| 7 | Comparing the effectiveness of polyethylene covers (Gladwrap) with lanolin (Duratears) eye ointment to prevent corneal abrasions in critically ill patients: a randomized controlled study显示文摘 | So HM Lee CC Leung AK | 2008 | Int J Nuts Stud2008，45，11： | 1 |
| 8 | The clinical usefulness of initial serum procalcitonin as an aggravation predictor in a hepatobiliary tract infection at emergency department显示文摘 | Jeong WJ So BH Kim HM | 2015 | Niger J Clin Pract2015，18，5： | 1 |
| 9 | Perception of stressors by patients and nurse of critical care units in Hong Kingpin 显示文摘 | So HM Chan DS | 2004 | J Knurs Stu2004，41，1： | 1 |
| 10 | Perception of stressors by patients and nurses of critical careunits in Hong Kong显示文摘 | So HM Chan DS | 2004 | Int J Nurs Stud2004，41，1： | 1 |
| 11 | Prevention of ventilator-associated pneumonia显示文摘 | Lau AC So HM Tang SL | 2015 | Hong Kong Med J2015，21，1： | 1 |
| 12 | The clinical usefulness of initial serum procalcitonin as an aggravation predictor in a hepatobiliary tract infection at emergency department显示文摘 | Jeong WJ So BH Kim HM | 2015 | Niger J Clin Pract2015，18，5： | 1 |
| 13 | Perioperative transient ischemic attack caused by the cessation of warfarin显示文摘 | Lee SO Li M J Ho HM | 2010 | Acta Anaesthesiol Taiwan2010，48，4： | 1 |
| 14 | Perception of stressors by patients and nurses of critical care units in Hong Kong 显示文摘 | So HM Chan DS | 2004 | Int J Nurs Stud2004，41，1： | 1 |
| 15 | Efficacy of incentive spirome ter exercise on pulmonary functions of patients with ankylosing spondylitis stabilized by tumor necrosis factor inhibitor therapy显示文摘 | So MW Heo HM Koo BS | 2012 | J Rheumatol2012，39，9： | 1 |
| 16 | Long-term out- of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation显示文摘 | ARULOGUN SO PRINCE HM NG J et ol | 2008 | Blood2008，112，8： | 1 |
| 17 | Toll-like receptors 2 and 4, and aeute phase cytokine gene expression in dexamethasone and growth hormone treated dairy calves 显示文摘 | Eicher SO McMunn KA Hammon HM | 2004 | Vet Immunol Immunopathol2004，98，34： | 1 |
| 18 | A critical appraisal of 'cronic Lyme disease' 显示文摘 | Feder HM Jr Johnson BJB Connell SO | 2007 | N Engl J Med2007，357，： | 1 |
| 19 | Cutaneoushypersensitivity to candida albicans in idiopathic vulvodynia显示文摘 | Ramirez-de-knott HM McCormick TS Do SO | 2005 | Contact Dermatitis2005，53，4： | 1 |
| 20 | Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry显示文摘 | Kong Alice PS Yang Xilin Luk Andrea Ma Ronald CW So Wing Yee Ozaki Risa Ting Rose Cheung Kitty Ho Chung Shun Chan Michael HM Chow Chun Chung Chan Juliana CN | 2014 | Diabetes Care2014，，4： | 1 |
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