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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | The Asia-Pacific Colo- rectal Screening score: a validated tool that stratifies risk for eoloreetal advanced neoplasia in asymptomatic Asian subjects显示文摘 | Yeoh KG Ho KY Chiu HM | 2011 | Gut2011，60，9： | 1 |
| 3 | Correlation between computerised find- ings and Newman's scaling on vascularity using power Doppler ultraso- nography imaging and its predictive value in patients with plantar fasci- itis显示文摘 | Chen H Ho HM Ying M | 2012 | Br J Radiol2012，85，1015： | 1 |
| 4 | Transmyocardial laser revascularization histological features in human nonresponder myocardium 显示文摘 | Gassler N Wintzer HO Stubbe HM | 1997 | Circulation1997，95，2： | 1 |
| 5 | Men's health:sexual dysfunction,physical,and psychological health--is there a link显示文摘 | Tan HM Tong SF Ho CC | | 0，，03： | 1 |
| 6 | Cost of tobacco-re-lated disease, including passive smoking,in HongKong 显示文摘 | Me Ghee S Ho LM Lapsley HM | 2006 | Tob Conerol2006，15，2： | 1 |
| 7 | Interaction of hepatitis B viral X protein and CCAAT/ enhancer- binding protein alpha synergistically aetivates the hepatitis B viral enhancer Ⅱ/pregenonic promoter 显示文摘 | Choi BH Park GT P ho HM | 1999 | J Biol Chem1999，274，5： | 1 |
| 8 | Web users'behavioral patterns of tourism information search:From online to offline显示文摘 | Ho CL Lin MH Chen HM | 2012 | Tourism Management2012，33，6： | 1 |
| 9 | Transmyocardial laser revascularization:histological features in human nonresponder myocardium显示文摘 | Gassler N Wintzer HO Stubbe HM | 1997 | Circulation1997，95，2： | 1 |
| 10 | Maltose adaptive mutant of heterotrophic marine bactefium,Alteromonas espejiana Bal-31:changes in the growth and the induction of extracellular alphaamylase显示文摘 | Lee TH Ho SL Chou HM | | 0，，03： | 1 |
| 11 | Guidelines on timing in replacing peripheral intravenous catheters显示文摘 | Ken HM Ho Daphne SK Cheung | 2012 | Journal of Clinical Nursing2012，21，： | 1 |
| 12 | Costof tobacco-related diseases, including passive smoking, in HongKong显示文摘 | McGhee S Ho LM Lapsley HM | 2006 | Tob Control2006，15，2： | 1 |
| 13 | Transmyocardial laser revascularization: histological features in human nonrepondder myocardium显示文摘 | Gassier N Wintzer HO Stubbe HM | 1997 | Circulation1997，95，： | 1 |
| 14 | The Asia--Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects显示文摘 | Yeoh KG Ho KY Chiu HM | 2011 | Gut2011，60，9： | 1 |
| 15 | Comparison of auto-moving table contrast-enhanced 3-D MRA and iodinated contrast-enhanced DSA for evaluating the lower-extremity arteries显示文摘 | Ho CF Wu MH Wu HM | 2004 | J Chin Med Assoc2004，67，10： | 1 |
| 16 | Perioperative transient ischemic at- tack caused by the cessation of warfarin 显示文摘 | Lee SO Li MJ Ho HM | 2010 | Acta Anaesthesiol Taiwan2010，48，4： | 1 |
| 17 | Comparing dose-response measurements of oral habits on oral leukoplakia and oral submucous fibrosis from a community screening program显示文摘 | Yang YH Ho PS Lu HM | | 0，，04： | 1 |
| 18 | Mobile-bearing knees reduce rotational asymmetric wear显示文摘 | Ho FY Ma HM Liau JJ | 2007 | Clin Orthop Relat Res2007，462，： | 1 |
| 19 | The Asia-Pacific Colorectal Screening score : a validated tool that stratifies risk for colorectal ad- vanced neoplasia in asymptomatic Asian subjects 显示文摘 | Yeoh KG Ho KY Chiu HM | 2011 | Gut2011，60，9： | 1 |
| 20 | Mobile-bearing knees reduce rotational asymmetric wear显示文摘 | Ho FY Ma HM Liau JJ | | 0，，： | 1 |
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